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Operation and performance of the ATLAS semiconductor tracker in LHC Run 2

Aad, Georges ; Abbott, Brad ; Abbott, Dale Charles ; [et al.]

IOP Publishing ; 2022

In: Journal of Instrumentation Vol. 17, No. 01 ( 2022-01-01), p. P01013-

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In: Journal of Instrumentation, IOP Publishing, Vol. 17, No. 01 ( 2022-01-01), p. P01013-

Abstract: The semiconductor tracker (SCT) is one of the tracking systems for charged particles in the ATLAS detector. It consists of 4088 silicon strip sensor modules. During Run 2 (2015–2018) the Large Hadron Collider delivered an integrated luminosity of 156 fb -1 to the ATLAS experiment at a centre-of-mass proton-proton collision energy of 13 TeV. The instantaneous luminosity and pile-up conditions were far in excess of those assumed in the original design of the SCT detector. Due to improvements to the data acquisition system, the SCT operated stably throughout Run 2. It was available for 99.9% of the integrated luminosity and achieved a data-quality efficiency of 99.85%. Detailed studies have been made of the leakage current in SCT modules and the evolution of the full depletion voltage, which are used to study the impact of radiation damage to the modules.

Type of Medium: Online Resource

ISSN: 1748-0221

URL: Article

DOI: 10.1088/1748-0221/17/01/P01013

Language: Unknown

Publisher: IOP Publishing

Publication Date: 2022

detail.hit.zdb_id: 2235672-1

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Applying the new intensive blood pressure categories to a nondialysis chronic kidney disease population: the Prevalence, Awareness and Treatment Rates in Chronic Kidney Disease Patients with Hypertension in China survey

Zheng, Ying ; Tang, Li ; Zhang, Weiguang ; [et al.]

Oxford University Press (OUP) ; 2018

In: Nephrology Dialysis Transplantation ( 2018-10-09)

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In: Nephrology Dialysis Transplantation, Oxford University Press (OUP), ( 2018-10-09)

Type of Medium: Online Resource

ISSN: 0931-0509 , 1460-2385

URL: Article

DOI: 10.1093/ndt/gfy301

Language: English

Publisher: Oxford University Press (OUP)

Publication Date: 2018

detail.hit.zdb_id: 1465709-0

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Imaging Parameters Predict Recurrence After Transient Ischemic Attack or Minor Stroke Stratified by ABCD 2 Score

Jing, Jing ; Suo, Yue ; Wang, Anxin ; [et al.]

Ovid Technologies (Wolters Kluwer Health) ; 2021

In: Stroke Vol. 52, No. 6 ( 2021-06), p. 2007-2015

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In: Stroke, Ovid Technologies (Wolters Kluwer Health), Vol. 52, No. 6 ( 2021-06), p. 2007-2015

Abstract: Whether imaging parameters would independently predict stroke recurrence in low-risk minor ischemic stroke (MIS) or transient ischemic attack (TIA) according to traditional score system (such as ABCD 2 score, which was termed on the basis of the initials of the five factors: age, blood pressure, clinical features, duration, diabetes) remains unclear. We sought to evaluate the association between imaging parameters and 1-year stroke recurrence in patients with TIA or MIS in different risk stratum stratified by ABCD 2 score. Methods: We included patients with TIA and MIS (National Institutes of Health Stroke Scale score ≤3) with complete baseline vessel and brain imaging data from the Third China National Stroke Registry III. Patients were categorized into different risk groups based on ABCD 2 score (low risk, 0–3; moderate risk, 4–5; and high risk, 6–7). The primary outcome was stroke recurrence within 1 year. Multivariable Cox proportional-hazards regression models were used to assess whether imaging parameters (large artery stenosis, infarction number) were independently associated with stroke recurrence. Results: Of the 7140 patients included, 584 patients experienced stroke recurrence within 1 year. According to the ABCD 2 score, large artery stenosis was associated with higher stroke recurrence in both low-risk (adjusted hazard ratio, 1.746 [95% CI, 1.200–2.540]) and moderate-risk group (adjusted hazard ratio, 1.326 [95% CI, 1.042–1.687] ) but not in the high-risk group ( P 〉 0.05). Patients with multiple acute infarctions or single acute infarction had a higher risk of recurrent stroke than those with no infarction in both low- and moderate-risk groups, but not in the high-risk group. Conclusions: Large artery stenosis and infarction number were independent predictors of 1-year stroke recurrence in low-moderate risk but not in high-risk patients with TIA or MIS stratified by ABCD 2 score. This finding emphasizes the importance of early brain and vascular imaging evaluation for risk stratification in patients with TIA or MIS.

Type of Medium: Online Resource

ISSN: 0039-2499 , 1524-4628

URL: Article

DOI: 10.1161/STROKEAHA.120.032424

RVK:

XA 10000

Language: English

Publisher: Ovid Technologies (Wolters Kluwer Health)

Publication Date: 2021

detail.hit.zdb_id: 1467823-8

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Periconception Red Blood Cell Folate and Offspring Congenital Heart Disease : Nested Case–Control and Mendelian Randomization Studies

Chen, Hongyan ; Zhang, Yi ; Wang, Dingmei ; [et al.]

American College of Physicians ; 2022

In: Annals of Internal Medicine Vol. 175, No. 9 ( 2022-09), p. 1212-1220

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In: Annals of Internal Medicine, American College of Physicians, Vol. 175, No. 9 ( 2022-09), p. 1212-1220

Type of Medium: Online Resource

ISSN: 0003-4819 , 1539-3704

URL: Article

DOI: 10.7326/M22-0741

RVK:

XA 23600

Language: English

Publisher: American College of Physicians

Publication Date: 2022

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Design and baseline characteristics of the Finerenone, in addition to standard of care, on the progression of kidney disease in patients with Non-Diabetic Chronic Kidney Disease (FIND-CKD) randomized trial

Heerspink, Hiddo J L ; Agarwal, Rajiv ; Bakris, George L ; [et al.]

Oxford University Press (OUP) ; 2024

In: Nephrology Dialysis Transplantation ( 2024-06-11)

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In: Nephrology Dialysis Transplantation, Oxford University Press (OUP), ( 2024-06-11)

Abstract: Finerenone, a non-steroidal mineralocorticoid receptor antagonist, improved kidney, and cardiovascular outcomes in patients with CKD and T2D in two Phase 3 outcome trials. The FIND-CKD study investigates the effect of finerenone in adults with CKD without diabetes. Methods FIND-CKD (NCT05047263 and EU CT 2023–506897-11–00) is a randomized, double-blind, placebo-controlled Phase 3 trial in patients with CKD of non-diabetic aetiology. Adults with a urinary albumin-creatinine ratio (UACR) of ≥ 200 to ≤3500 mg/g and eGFR ≥ 25 to & lt;90 mL/min/1.73 m2 receiving a maximum tolerated dose of a renin-angiotensin-system (RAS) inhibitor were randomized 1:1 to once daily placebo or finerenone 10 or 20 mg depending on eGFR above or below 60 mL/min/1.73 m2. The primary efficacy outcome is total eGFR slope, defined as the mean annual rate of change in eGFR from baseline to Month 32. Secondary efficacy outcomes include a combined cardiorenal composite outcome comprising time to kidney failure, sustained ≥57% decrease in eGFR, hospitalization for heart failure, or cardiovascular death, as well as separate kidney and cardiovascular composite outcomes. Adverse events are recorded to assess tolerability and safety. Results Across 24 countries, 3231 patients were screened and 1584 were randomized to study treatment. The most common causes of CKD were chronic glomerulonephritis (57.0%) and hypertensive/ischaemic nephropathy (29.0%). Immunoglobulin A nephropathy was the most common glomerulonephritis (26.3% of the total population). At baseline, mean eGFR and median UACR were 46.7 mL/min/1.73 m2 and 818.9 mg/g, respectively. Diuretics were used by 282 participants (17.8%), statins by 851 (53.7%), and calcium channel blockers by 794 (50.1%). SGLT2 inhibitors were used in 16.9% of patients; these individuals had a similar mean eGFR (45.6 vs 46.8 mL/min/1.73 m2) and slightly higher median UACR (871.9 vs 808.3 mg/g) compared to those not using SGLT2 inhibitors at baseline. Conclusions FIND-CKD is the first Phase 3 trial of finerenone in patients with CKD of non-diabetic aetiology.

Type of Medium: Online Resource

ISSN: 0931-0509 , 1460-2385

URL: Article

DOI: 10.1093/ndt/gfae132

Language: English

Publisher: Oxford University Press (OUP)

Publication Date: 2024

detail.hit.zdb_id: 1465709-0

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Circumferential Pulmonary Vein Isolation With vs Without Additional Low-Voltage-Area Ablation in Older Patients With Paroxysmal Atrial Fibrillation : A Randomized Clinical Trial

Chen, Hongwu ; Li, Chengzong ; Han, Bing ; [et al.]

American Medical Association (AMA) ; 2023

In: JAMA Cardiology Vol. 8, No. 8 ( 2023-08-01), p. 765-

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In: JAMA Cardiology, American Medical Association (AMA), Vol. 8, No. 8 ( 2023-08-01), p. 765-

Abstract: The overall success rate of circumferential pulmonary vein isolation (CPVI) treatment in patients with paroxysmal atrial fibrillation (AF) remains suboptimal, especially in older patients. Objective To explore the incremental benefit of low-voltage-area ablation after CPVI in older patients with paroxysmal AF. Design, Setting, and Participants This randomized clinical trial was an investigator-initiated trial to compare the efficacy of additional low-voltage-area ablation beyond CPVI vs CPVI alone in older patients with paroxysmal AF. Participants were patients aged 65 to 80 years with paroxysmal AF who were referred for catheter ablation. They were enrolled in 14 tertiary hospitals in China from April 1, 2018, to August 3, 2020, and follow-up occurred through August 15, 2021. Interventions Patients were randomized (1:1) to undergo CPVI plus low-voltage-area ablation or CPVI alone. Low-voltage areas were defined as areas with amplitude less than 0.5 mV in more than 3 adjacent points. If low-voltage areas existed, additional substrate ablation was performed in the CPVI plus group but not the CPVI alone group. Main Outcomes and Measures The primary end point of the study was freedom from atrial tachyarrhythmia as documented by electrocardiogram during a clinical visit or lasting longer than 30 seconds during Holter recordings occurring after a single ablation procedure. Results Among 438 patients who were randomized (mean [SD] age, 70.5 [4.4] years; 219 men [50%]), 24 (5.5%) did not complete the blanking period and were not included for efficacy analysis. After a median follow-up of 23 months, the recurrence rate of atrial tachyarrhythmia was significantly lower in the CPVI plus group (31/209 patients, 15%) compared with the CPVI alone group (49/205, 24%; hazard ratio [HR] , 0.61; 95% CI, 0.38-0.95; P = .03). In subgroup analyses, among all patients with low-voltage area, CPVI plus substrate modification was associated with a 51% decreased risk of ATA recurrence compared with CPVI alone (HR, 0.49; 95% CI, 0.25-0.94; P = .03). Conclusions and Relevance This study found that additional low-voltage-area ablation beyond CPVI decreased the ATA recurrence in older patients with paroxysmal AF compared with CPVI alone. Our findings merit further replication by larger trials with longer follow-up. Trial Registration ClinicalTrials.gov Identifier: NCT03462628

Type of Medium: Online Resource

ISSN: 2380-6583

URL: Article

DOI: 10.1001/jamacardio.2023.1749

Language: English

Publisher: American Medical Association (AMA)

Publication Date: 2023

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Effect of Oral Methylprednisolone on Decline in Kidney Function or Kidney Failure in Patients With IgA Nephropathy : The TESTING Randomized Clinical Trial

Lv, Jicheng ; Wong, Muh Geot ; Hladunewich, Michelle A. ; [et al.]

American Medical Association (AMA) ; 2022

In: JAMA Vol. 327, No. 19 ( 2022-05-17), p. 1888-

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In: JAMA, American Medical Association (AMA), Vol. 327, No. 19 ( 2022-05-17), p. 1888-

Type of Medium: Online Resource

ISSN: 0098-7484

URL: Article

DOI: 10.1001/jama.2022.5368

RVK:

XA 10000

Language: English

Publisher: American Medical Association (AMA)

Publication Date: 2022

detail.hit.zdb_id: 2958-0

detail.hit.zdb_id: 2018410-4

SSG: 5,21

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Redefining Cardiac Biomarkers in Predicting Mortality of Inpatients With COVID-19

Qin, Juan-Juan ; Cheng, Xu ; Zhou, Feng ; [et al.]

Ovid Technologies (Wolters Kluwer Health) ; 2020

In: Hypertension Vol. 76, No. 4 ( 2020-10), p. 1104-1112

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In: Hypertension, Ovid Technologies (Wolters Kluwer Health), Vol. 76, No. 4 ( 2020-10), p. 1104-1112

Abstract: The prognostic power of circulating cardiac biomarkers, their utility, and pattern of release in coronavirus disease 2019 (COVID-19) patients have not been clearly defined. In this multicentered retrospective study, we enrolled 3219 patients with diagnosed COVID-19 admitted to 9 hospitals from December 31, 2019 to March 4, 2020, to estimate the associations and prognostic power of circulating cardiac injury markers with the poor outcomes of COVID-19. In the mixed-effects Cox model, after adjusting for age, sex, and comorbidities, the adjusted hazard ratio of 28-day mortality for hs-cTnI (high-sensitivity cardiac troponin I) was 7.12 ([95% CI, 4.60–11.03] P 〈 0.001), (NT-pro)BNP (N-terminal pro-B-type natriuretic peptide or brain natriuretic peptide) was 5.11 ([95% CI, 3.50–7.47] P 〈 0.001), CK (creatine phosphokinase)-MB was 4.86 ([95% CI, 3.33–7.09] P 〈 0.001), MYO (myoglobin) was 4.50 ([95% CI, 3.18–6.36] P 〈 0.001), and CK was 3.56 ([95% CI, 2.53–5.02] P 〈 0.001). The cutoffs of those cardiac biomarkers for effective prognosis of 28-day mortality of COVID-19 were found to be much lower than for regular heart disease at about 19%–50% of the currently recommended thresholds. Patients with elevated cardiac injury markers above the newly established cutoffs were associated with significantly increased risk of COVID-19 death. In conclusion, cardiac biomarker elevations are significantly associated with 28-day death in patients with COVID-19. The prognostic cutoff values of these biomarkers might be much lower than the current reference standards. These findings can assist in better management of COVID-19 patients to improve outcomes. Importantly, the newly established cutoff levels of COVID-19–associated cardiac biomarkers may serve as useful criteria for the future prospective studies and clinical trials.

Type of Medium: Online Resource

ISSN: 0194-911X , 1524-4563

URL: Article

DOI: 10.1161/HYPERTENSIONAHA.120.15528

Language: English

Publisher: Ovid Technologies (Wolters Kluwer Health)

Publication Date: 2020

detail.hit.zdb_id: 2094210-2

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Improving Health Literacy: Analysis of the Relationship between Residents’ Usage of Information Channels and Health Literacy in Shanghai, China

Gao, Ya ; Chen, Chen ; Hui, Hong ; [et al.]

MDPI AG ; 2022

In: International Journal of Environmental Research and Public Health Vol. 19, No. 10 ( 2022-05-23), p. 6324-

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In: International Journal of Environmental Research and Public Health, MDPI AG, Vol. 19, No. 10 ( 2022-05-23), p. 6324-

Abstract: Background: This study aimed to examine the relationship between residents’ health literacy (HL) and their use of and trust in information channels. Methods: A community-based cross-sectional health survey utilizing a cluster sampling design was conducted in January 2022. The sample consisted of 1067 residents in Shanghai, China. Those who correctly answered over 80% of the questions were regarded as qualified. The differences in residents’ HL and the dimensions of knowledge HL, lifestyle HL, and skills HL were analyzed based on their use of and trust in traditional media, the internet, and offline activities. Logistic regression was conducted to examine the effects of the usage of these channels on all four types of HL. Results: A total of 27.65% of participants were qualified for HL. The use of traditional media (OR = 1.405, p 〈 0.05) and engagement in offline activities (OR = 1.951, p 〈 0.05) were significantly related to HL. Disbelief in traditional media was related to being qualified in knowledge HL (OR = 1.262; p 〈 0.05), whereas disbelief in offline activities had an adverse effect on knowledge HL and skills HL (OR = 0.700, 0.807; p 〈 0.05). Conclusion: Effort should be made to improve the efficiency of offline health education, and ensure the reliability and quality of health-related information from mass media and the internet to improve residents’ HL.

Type of Medium: Online Resource

ISSN: 1660-4601

URL: Article

DOI: 10.3390/ijerph19106324

Language: English

Publisher: MDPI AG

Publication Date: 2022

detail.hit.zdb_id: 2175195-X

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DataSheet2.PDF

Chen, Tongzuan ; zhao, Liqian ; Chen, Junbo ; [et al.]

Frontiers Media SA ; 2023

In: Frontiers in Genetics Vol. 14 ( 2023-2-10)

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In: Frontiers in Genetics, Frontiers Media SA, Vol. 14 ( 2023-2-10)

Abstract: Gastric cancer (GC) is highly heterogeneous and GC patients have low overall survival rates. It is also challenging to predict the prognosis of GC patients. This is partly because little is known about the prognosis-related metabolic pathways in this disease. Hence, our objective was to identify GC subtypes and genes related to prognosis, based on changes in the activity of core metabolic pathways in GC tumor samples. Differences in the activity of metabolic pathways in GC patients were analyzed using Gene Set Variation Analysis (GSVA), leading to the identification of three clinical subtypes by non-negative matrix factorization (NMF). Based on our analysis, subtype 1 showed the best prognosis while subtype 3 exhibited the worst prognosis. Interestingly, we observed marked differences in gene expression between the three subtypes, through which we identified a new evolutionary driver gene, CNBD1. Furthermore, we used 11 metabolism-associated genes identified by LASSO and random forest algorithms to construct a prognostic model and verified our results using qRT-PCR (five matched clinical tissues of GC patients). This model was found to be both effective and robust in the GSE84437 and GSE26253 cohorts, and the results from multivariate Cox regression analyses confirmed that the 11-gene signature was an independent prognostic predictor ( p & lt; 0.0001, HR = 2.8, 95% CI 2.1–3.7). The signature was found to be relevant to the infiltration of tumor-associated immune cells. In conclusion, our work identified significant GC prognosis-related metabolic pathways in different GC subtypes and provided new insights into GC-subtype prognostic assessment.

Type of Medium: Online Resource

ISSN: 1664-8021

URL: Article

DOI: 10.3389/fgene.2023.1094838

DOI: 10.3389/fgene.2023.1094838.s001

DOI: 10.3389/fgene.2023.1094838.s002

Language: Unknown

Publisher: Frontiers Media SA

Publication Date: 2023

detail.hit.zdb_id: 2606823-0

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