In:
Journal of Neurochemistry, Wiley, Vol. 139, No. 6 ( 2016-12), p. 1151-1162
Abstract:
Rifampicin, a broad‐spectrum antibiotic, has neuroprotective, immunosuppressive, and anti‐inflammatory properties. However, the effect of rifampicin on autoimmune disorders of the nervous system is not clear. In this study, we investigated whether rifampicin was beneficial to myelin oligodendrocyte glycoprotein peptide ( MOG 33–35 )‐induced female C57 BL /6 experimental autoimmune encephalomyelitis ( EAE ) mice, the well‐established animal model of multiple sclerosis. Rifampicin treatment (daily from the first day after EAE immunization) remarkably attenuated clinical signs and loss of body weight, which are associated with suppression of inflammatory infiltration and demyelination in spinal cords of EAE mice. Furthermore, rifampicin dramatically reduced the disruption of blood–brain barrier integrity, down‐regulated serum concentration of IL ‐6 and IL ‐17A, inhibited pathological Th17 cell differentiation, and modulated the expression of p‐ STAT 3 and p‐p65. These results suggest that rifampicin is effective for attenuating the clinical severity of EAE mice, which may be related to its inhibitive ability in differentiation of Th17 cell and secretion of its key effector molecule IL ‐17A via regulation of excessive activation of the key signaling molecules of JAK / STAT pathway. Our findings may be helpful for developing therapeutic and preventive strategies for multiple sclerosis. image
Type of Medium:
Online Resource
ISSN:
0022-3042
,
1471-4159
DOI:
10.1111/jnc.2016.139.issue-6
Language:
English
Publisher:
Wiley
Publication Date:
2016
detail.hit.zdb_id:
2020528-4
SSG:
12
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