In:
PLOS Genetics, Public Library of Science (PLoS), Vol. 17, No. 2 ( 2021-2-11), p. e1009273-
Kurzfassung:
Epidemiological studies of obesity, Type-2 diabetes (T2D), cardiovascular diseases and several common cancers have revealed an increased risk in Native Hawaiians compared to European- or Asian-Americans living in the Hawaiian islands. However, there remains a gap in our understanding of the genetic factors that affect the health of Native Hawaiians. To fill this gap, we studied the genetic risk factors at both the chromosomal and sub-chromosomal scales using genome-wide SNP array data on ~4,000 Native Hawaiians from the Multiethnic Cohort. We estimated the genomic proportion of Native Hawaiian ancestry (“global ancestry,” which we presumed to be Polynesian in origin), as well as this ancestral component along each chromosome (“local ancestry”) and tested their respective association with binary and quantitative cardiometabolic traits. After attempting to adjust for non-genetic covariates evaluated through questionnaires, we found that per 10% increase in global Polynesian genetic ancestry, there is a respective 8.6%, and 11.0% increase in the odds of being diabetic ( P = 1.65×10 −4 ) and having heart failure ( P = 2.18×10 −4 ), as well as a 0.059 s.d. increase in BMI ( P = 1.04×10 −10 ). When testing the association of local Polynesian ancestry with risk of disease or biomarkers, we identified a chr6 region associated with T2D. This association was driven by an uniquely prevalent variant in Polynesian ancestry individuals. However, we could not replicate this finding in an independent Polynesian cohort from Samoa due to the small sample size of the replication cohort. In conclusion, we showed that Polynesian ancestry, which likely capture both genetic and lifestyle risk factors, is associated with an increased risk of obesity, Type-2 diabetes, and heart failure, and that larger cohorts of Polynesian ancestry individuals will be needed to replicate the putative association on chr6 with T2D.
Materialart:
Online-Ressource
ISSN:
1553-7404
DOI:
10.1371/journal.pgen.1009273
DOI:
10.1371/journal.pgen.1009273.g001
DOI:
10.1371/journal.pgen.1009273.g002
DOI:
10.1371/journal.pgen.1009273.g003
DOI:
10.1371/journal.pgen.1009273.t001
DOI:
10.1371/journal.pgen.1009273.t002
DOI:
10.1371/journal.pgen.1009273.t003
DOI:
10.1371/journal.pgen.1009273.t004
DOI:
10.1371/journal.pgen.1009273.s001
DOI:
10.1371/journal.pgen.1009273.s002
DOI:
10.1371/journal.pgen.1009273.s003
DOI:
10.1371/journal.pgen.1009273.s004
DOI:
10.1371/journal.pgen.1009273.s005
DOI:
10.1371/journal.pgen.1009273.s006
DOI:
10.1371/journal.pgen.1009273.s007
DOI:
10.1371/journal.pgen.1009273.s008
DOI:
10.1371/journal.pgen.1009273.s009
DOI:
10.1371/journal.pgen.1009273.s010
DOI:
10.1371/journal.pgen.1009273.s011
DOI:
10.1371/journal.pgen.1009273.s012
DOI:
10.1371/journal.pgen.1009273.s013
DOI:
10.1371/journal.pgen.1009273.s014
DOI:
10.1371/journal.pgen.1009273.s015
DOI:
10.1371/journal.pgen.1009273.s016
DOI:
10.1371/journal.pgen.1009273.s017
DOI:
10.1371/journal.pgen.1009273.s018
DOI:
10.1371/journal.pgen.1009273.s019
DOI:
10.1371/journal.pgen.1009273.s020
DOI:
10.1371/journal.pgen.1009273.s021
DOI:
10.1371/journal.pgen.1009273.s022
DOI:
10.1371/journal.pgen.1009273.s023
DOI:
10.1371/journal.pgen.1009273.s024
DOI:
10.1371/journal.pgen.1009273.s025
DOI:
10.1371/journal.pgen.1009273.s026
DOI:
10.1371/journal.pgen.1009273.s027
DOI:
10.1371/journal.pgen.1009273.s028
DOI:
10.1371/journal.pgen.1009273.s029
DOI:
10.1371/journal.pgen.1009273.s030
DOI:
10.1371/journal.pgen.1009273.s031
DOI:
10.1371/journal.pgen.1009273.s032
DOI:
10.1371/journal.pgen.1009273.s033
DOI:
10.1371/journal.pgen.1009273.s034
DOI:
10.1371/journal.pgen.1009273.s035
Sprache:
Englisch
Verlag:
Public Library of Science (PLoS)
Publikationsdatum:
2021
ZDB Id:
2186725-2
Bookmarklink