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Rat Merkel Cells Are Mechanoreceptors and Osmoreceptors

Boulais, Nicholas ; Pennec, Jean-Pierre ; Lebonvallet, Nicolas ; [et al.]

Public Library of Science (PLoS) ; 2009

In: PLoS ONE Vol. 4, No. 11 ( 2009-11-9), p. e7759-

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In: PLoS ONE, Public Library of Science (PLoS), Vol. 4, No. 11 ( 2009-11-9), p. e7759-

Type of Medium: Online Resource

ISSN: 1932-6203

URL: Article

DOI: 10.1371/journal.pone.0007759

DOI: 10.1371/journal.pone.0007759.g001

DOI: 10.1371/journal.pone.0007759.g002

DOI: 10.1371/journal.pone.0007759.g003

DOI: 10.1371/journal.pone.0007759.g004

DOI: 10.1371/journal.pone.0007759.g005

DOI: 10.1371/journal.pone.0007759.g006

DOI: 10.1371/journal.pone.0007759.g007

DOI: 10.1371/journal.pone.0007759.g008

DOI: 10.1371/journal.pone.0007759.g009

DOI: 10.1371/journal.pone.0007759.g010

DOI: 10.1371/journal.pone.0007759.g011

DOI: 10.1371/journal.pone.0007759.g012

DOI: 10.1371/journal.pone.0007759.t001

Language: English

Publisher: Public Library of Science (PLoS)

Publication Date: 2009

detail.hit.zdb_id: 2267670-3

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Merkel Cells as Putative Regulatory Cells in Skin Disorders: An In Vitro Study

Boulais, Nicholas ; Pereira, Ulysse ; Lebonvallet, Nicolas ; [et al.]

Public Library of Science (PLoS) ; 2009

In: PLoS ONE Vol. 4, No. 8 ( 2009-8-11), p. e6528-

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In: PLoS ONE, Public Library of Science (PLoS), Vol. 4, No. 8 ( 2009-8-11), p. e6528-

Type of Medium: Online Resource

ISSN: 1932-6203

URL: Article

DOI: 10.1371/journal.pone.0006528

DOI: 10.1371/journal.pone.0006528.g001

DOI: 10.1371/journal.pone.0006528.g002

DOI: 10.1371/journal.pone.0006528.g003

DOI: 10.1371/journal.pone.0006528.g004

DOI: 10.1371/journal.pone.0006528.g005

DOI: 10.1371/journal.pone.0006528.g006

DOI: 10.1371/journal.pone.0006528.g007

DOI: 10.1371/journal.pone.0006528.g008

Language: English

Publisher: Public Library of Science (PLoS)

Publication Date: 2009

detail.hit.zdb_id: 2267670-3

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Dual-Color Fluorescence Imaging to Monitor CYP3A4 and CYP3A7 Expression in Human Hepatic Carcinoma HepG2 and HepaRG Cells

Tsuji, Saori ; Kawamura, Fumihiko ; Kubiura, Musashi ; [et al.]

Public Library of Science (PLoS) ; 2014

In: PLoS ONE Vol. 9, No. 8 ( 2014-8-7), p. e104123-

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In: PLoS ONE, Public Library of Science (PLoS), Vol. 9, No. 8 ( 2014-8-7), p. e104123-

Type of Medium: Online Resource

ISSN: 1932-6203

URL: Article

DOI: 10.1371/journal.pone.0104123

DOI: 10.1371/journal.pone.0104123.g001

DOI: 10.1371/journal.pone.0104123.g002

DOI: 10.1371/journal.pone.0104123.g003

DOI: 10.1371/journal.pone.0104123.g004

DOI: 10.1371/journal.pone.0104123.g005

DOI: 10.1371/journal.pone.0104123.g006

DOI: 10.1371/journal.pone.0104123.g007

DOI: 10.1371/journal.pone.0104123.g008

DOI: 10.1371/journal.pone.0104123.t001

DOI: 10.1371/journal.pone.0104123.t002

DOI: 10.1371/journal.pone.0104123.t003

DOI: 10.1371/journal.pone.0104123.s001

DOI: 10.1371/journal.pone.0104123.s002

DOI: 10.1371/journal.pone.0104123.s003

DOI: 10.1371/journal.pone.0104123.s004

DOI: 10.1371/journal.pone.0104123.s005

Language: English

Publisher: Public Library of Science (PLoS)

Publication Date: 2014

detail.hit.zdb_id: 2267670-3

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In vitro micronucleus test in living cells associating biological tracers and high-content imaging

Mirey, Gladys ; Graillot, Vanessa ; Mondesert, Odile ; [et al.]

Elsevier BV ; 2017

In: Toxicology Letters Vol. 280 ( 2017-10), p. S322-

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In: Toxicology Letters, Elsevier BV, Vol. 280 ( 2017-10), p. S322-

Type of Medium: Online Resource

ISSN: 0378-4274

URL: Article

DOI: 10.1016/j.toxlet.2017.08.072

Language: English

Publisher: Elsevier BV

Publication Date: 2017

detail.hit.zdb_id: 1500784-4

SSG: 12

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Novel human hepatic organoid model enables testing of drug-induced liver fibrosis in vitro

Leite, Sofia B. ; Roosens, Tiffany ; El Taghdouini, Adil ; [et al.]

Elsevier BV ; 2016

In: Biomaterials Vol. 78 ( 2016-02), p. 1-10

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In: Biomaterials, Elsevier BV, Vol. 78 ( 2016-02), p. 1-10

Type of Medium: Online Resource

ISSN: 0142-9612

URL: Article

DOI: 10.1016/j.biomaterials.2015.11.026

Language: English

Publisher: Elsevier BV

Publication Date: 2016

detail.hit.zdb_id: 2004010-6

SSG: 12

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Systematic Analysis of Blood Cell Transcriptome in End-Stage Chronic Respiratory Diseases

Chesné, Julie ; Danger, Richard ; Botturi, Karine ; [et al.]

Public Library of Science (PLoS) ; 2014

In: PLoS ONE Vol. 9, No. 10 ( 2014-10-20), p. e109291-

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In: PLoS ONE, Public Library of Science (PLoS), Vol. 9, No. 10 ( 2014-10-20), p. e109291-

Type of Medium: Online Resource

ISSN: 1932-6203

URL: Article

DOI: 10.1371/journal.pone.0109291

DOI: 10.1371/journal.pone.0109291.g001

DOI: 10.1371/journal.pone.0109291.g002

DOI: 10.1371/journal.pone.0109291.g003

DOI: 10.1371/journal.pone.0109291.g004

DOI: 10.1371/journal.pone.0109291.g005

DOI: 10.1371/journal.pone.0109291.g006

DOI: 10.1371/journal.pone.0109291.t001

DOI: 10.1371/journal.pone.0109291.t002

DOI: 10.1371/journal.pone.0109291.t003

DOI: 10.1371/journal.pone.0109291.t004

DOI: 10.1371/journal.pone.0109291.s001

Language: English

Publisher: Public Library of Science (PLoS)

Publication Date: 2014

detail.hit.zdb_id: 2267670-3

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Expression and Transport Function of Drug Uptake Transporters in Differentiated HepaRG Cells

Kotani, Naoki ; Maeda, Kazuya ; Debori, Yasuyuki ; [et al.]

American Chemical Society (ACS) ; 2012

In: Molecular Pharmaceutics Vol. 9, No. 12 ( 2012-12-03), p. 3434-3441

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In: Molecular Pharmaceutics, American Chemical Society (ACS), Vol. 9, No. 12 ( 2012-12-03), p. 3434-3441

Type of Medium: Online Resource

ISSN: 1543-8384 , 1543-8392

URL: Article

DOI: 10.1021/mp300171p

Language: English

Publisher: American Chemical Society (ACS)

Publication Date: 2012

detail.hit.zdb_id: 2132489-X

SSG: 15,3

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Tunisian 〈i〉Clematis flammula〈/i〉 Essential Oil Enhances Wound Healing: GC-MS Analysis, Biochemical and Histological Assessment

Saidi, Rakia ; Ghrab, Ferdaws ; Kallel, Rim ; [et al.]

Japan Oil Chemists' Society ; 2018

In: Journal of Oleo Science Vol. 67, No. 11 ( 2018), p. 1483-1499

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In: Journal of Oleo Science, Japan Oil Chemists' Society, Vol. 67, No. 11 ( 2018), p. 1483-1499

Type of Medium: Online Resource

ISSN: 1345-8957 , 1347-3352

URL: Article

DOI: 10.5650/jos.ess18056

Language: English

Publisher: Japan Oil Chemists' Society

Publication Date: 2018

detail.hit.zdb_id: 2218264-0

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Expansion of human primary hepatocytes in vitro through their amplification as liver progenitors in a 3D organoid system

Garnier, Delphine ; Li, Ruoya ; Delbos, Frédéric ; [et al.]

Springer Science and Business Media LLC ; 2018

In: Scientific Reports Vol. 8, No. 1 ( 2018-05-29)

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In: Scientific Reports, Springer Science and Business Media LLC, Vol. 8, No. 1 ( 2018-05-29)

Abstract: Despite decades of investigation on the proliferation of adult human primary hepatocytes, their expansion in vitro still remains challenging. To later be able to consider hepatocytes as a cell therapy alternative or bridge to liver transplantation, dramatically impeded by a shortage in liver donors, the first step is having an almost unlimited source of these cells. The banking of transplantable hepatocytes also implies a protocol for their expansion that can be compatible with large-scale production. We show that adult human primary hepatocytes when grown in 3D organoids are easily amplified, providing a substantial source of functional hepatocytes ready for transplantation. Following their plating, differentiated human hepatocytes are amplified during a transient and reversible step as liver progenitors, and can subsequently be converted back to mature differentiated hepatocytes. The protocol we propose is not only compatible with automated and high-throughput cell culture systems, thanks to the expansion of hepatocytes in suspension, but also guarantees the generation of a high number of functional cells from the same patient sample, with a relatively easy set up.

Type of Medium: Online Resource

ISSN: 2045-2322

URL: Article

DOI: 10.1038/s41598-018-26584-1

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2018

detail.hit.zdb_id: 2615211-3

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A Multicentre Study of Acute In Vitro Cytotoxicity in Rat Hepatocytes: Tentative Correlation Between In Vitro Toxicities and In Vivo Data

Fautrel, Alain ; Chesné, Christophe ; Guillouzo, André ; [et al.]

SAGE Publications ; 1993

In: Alternatives to Laboratory Animals Vol. 21, No. 2 ( 1993-04), p. 281-284

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In: Alternatives to Laboratory Animals, SAGE Publications, Vol. 21, No. 2 ( 1993-04), p. 281-284

Abstract: A multicentre validation study of the acute in vitro cytotoxicities of 31 liquid or solid chemicals was carried out by six laboratories, using primary rat hepatocyte cultures as a model system. We report here a comparison of neutral red uptake IC50 and LD50 values. Oral, i.p. and i.v. LD50 values were available for 27, 24 and 18 chemicals, respectively, and an IC50 value was obtained for 15, 14 and 11 of these compounds, respectively. A significant correlation was found only between IC50 and i.v. LD50 values.

Type of Medium: Online Resource

ISSN: 0261-1929 , 2632-3559

URL: Article

DOI: 10.1177/026119299302100223

Language: English

Publisher: SAGE Publications

Publication Date: 1993

detail.hit.zdb_id: 2390905-5

SSG: 12,22

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