KOBV Portal

Hits per page

hits 1 - 10 | 294 hits

Sorting

Online Resource

Characteristics of Chinese herbal medicine usage in ischemic heart disease patients among type 2 diabetes and their protection against hydrogen peroxide-mediated apoptosis in H9C2 cardiomyoblasts

Tsai, Fuu-Jen ; Ho, Tsung-Jung ; Cheng, Chi-Fung ; [et al.]

Impact Journals, LLC ; 2017

In: Oncotarget Vol. 8, No. 9 ( 2017-02-28), p. 15470-15489

add to watchlist on the watchlist

Details

In: Oncotarget, Impact Journals, LLC, Vol. 8, No. 9 ( 2017-02-28), p. 15470-15489

Type of Medium: Online Resource

ISSN: 1949-2553

URL: Issue

URL: Article

DOI: 10.18632/oncotarget.v8i9

DOI: 10.18632/oncotarget.14657

Language: English

Publisher: Impact Journals, LLC

Publication Date: 2017

detail.hit.zdb_id: 2560162-3

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

BTU Cottbus

Wissenschaftspark Albert Einstein

EUV Frankfurt

TH Wildau

FH Potsdam

Online Resource

KCNQ1 variants associate with hypertension in type 2 diabetes and affect smooth muscle contractility in vitro

Huang, Kuo‐Chin ; Li, Te‐Mao ; Liu, Xiang ; [et al.]

Wiley ; 2017

In: Journal of Cellular Physiology Vol. 232, No. 12 ( 2017-12), p. 3309-3316

add to watchlist on the watchlist

Details

In: Journal of Cellular Physiology, Wiley, Vol. 232, No. 12 ( 2017-12), p. 3309-3316

Abstract: KCNQ1 encodes a potassium voltage‐gated channel and represents a susceptibility locus for type 2 diabetes mellitus (T2DM). Here, we explored the association between KCNQ1 polymorphisms and hypertension risk in individuals with T2DM, as well as the role of KCNQ1 in vascular smooth muscle cell contraction in vitro. To investigate the relationship between KCNQ1 and the risk of developing hypertension in patients with T2DM, we divided the T2DM cohort into hypertension ( n = 452) and non‐hypertension ( n = 541) groups. The Mann–Whitney U test, chi‐square test, and multivariate regression analyses were used to assess the clinical characteristics and genotypic frequencies. In vitro studies utilized the rat aortic smooth muscle A10 cell line. Patients in the hypertension group were significantly older at the time of enrollment and had higher levels of body mass index, waist‐to‐hip ratio, and triglyceride than those in the non‐hypertension group. The KCNQ1 rs3864884 and rs12576239 genetic variants were associated with hypertension in T2DM. KCNQ1 expression was lower in the individuals with the CC versus the CT and TT genotypes. Smooth muscle cell contractility was inhibited by treatment with a KCNQ1 inhibitor. These results suggest that KCNQ1 might be associated with hypertension in individuals with T2DM.

Type of Medium: Online Resource

ISSN: 0021-9541 , 1097-4652

URL: Issue

URL: Article

DOI: 10.1002/jcp.v232.12

DOI: 10.1002/jcp.25775

Language: English

Publisher: Wiley

Publication Date: 2017

detail.hit.zdb_id: 1478143-8

SSG: 12

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

BTU Cottbus

Wissenschaftspark Albert Einstein

EUV Frankfurt

TH Wildau

FH Potsdam

Online Resource

Association between GRIN3A Gene Polymorphism in Kawasaki Disease and Coronary Artery Aneurysms in Taiwanese Children

Lin, Ying-Ju ; Chang, Jeng-Sheng ; Liu, Xiang ; [et al.]

Public Library of Science (PLoS) ; 2013

In: PLoS ONE Vol. 8, No. 11 ( 2013-11-22), p. e81384-

add to watchlist on the watchlist

Details

In: PLoS ONE, Public Library of Science (PLoS), Vol. 8, No. 11 ( 2013-11-22), p. e81384-

Type of Medium: Online Resource

ISSN: 1932-6203

URL: Article

DOI: 10.1371/journal.pone.0081384

DOI: 10.1371/journal.pone.0081384.g001

DOI: 10.1371/journal.pone.0081384.t001

DOI: 10.1371/journal.pone.0081384.t002

DOI: 10.1371/journal.pone.0081384.t003

DOI: 10.1371/journal.pone.0081384.s001

DOI: 10.1371/journal.pone.0081384.s002

DOI: 10.1371/journal.pone.0081384.s003

DOI: 10.1371/journal.pone.0081384.s004

DOI: 10.1371/journal.pone.0081384.s005

DOI: 10.1371/journal.pone.0081384.s006

DOI: 10.1371/journal.pone.0081384.s007

DOI: 10.1371/journal.pone.0081384.s008

DOI: 10.1371/journal.pone.0081384.s009

DOI: 10.1371/journal.pone.0081384.s010

DOI: 10.1371/journal.pone.0081384.s011

DOI: 10.1371/journal.pone.0081384.s012

DOI: 10.1371/journal.pone.0081384.s013

DOI: 10.1371/journal.pone.0081384.s014

Language: English

Publisher: Public Library of Science (PLoS)

Publication Date: 2013

detail.hit.zdb_id: 2267670-3

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

BTU Cottbus

Wissenschaftspark Albert Einstein

EUV Frankfurt

TH Wildau

FH Potsdam

Online Resource

Genetic variants in PLCB4/PLCB1 as susceptibility loci for coronary artery aneurysm formation in Kawasaki disease in Han Chinese in Taiwan

Lin, Ying-Ju ; Chang, Jeng-Sheng ; Liu, Xiang ; [et al.]

Springer Science and Business Media LLC ; 2015

In: Scientific Reports Vol. 5, No. 1 ( 2015-10-05)

add to watchlist on the watchlist

Details

In: Scientific Reports, Springer Science and Business Media LLC, Vol. 5, No. 1 ( 2015-10-05)

Abstract: Kawasaki disease (KD) is an acute, inflammatory and self-limited vasculitis affecting infants and young children. Coronary artery aneurysm (CAA) formation is the major complication of KD and the leading cause of acquired cardiovascular disease among children. To identify susceptible loci that might predispose patients with KD to CAA formation, a genome-wide association screen was performed in a Taiwanese KD cohort. Patients with both KD and CAA had longer fever duration and delayed intravenous immunoglobulin treatment time. After adjusting for these factors, 100 susceptibility loci were identified. Four genes were identified from a single cluster of 35 using the Ingenuity Pathway Analysis (IPA) Knowledge Base. Silencing KCNQ5 , PLCB1 , PLCB4 and PLCL1 inhibited the effect of lipopolysaccharide-induced endothelial cell inflammation with varying degrees of proinflammatory cytokine expression. PLCB1 showed the most significant inhibition. Endothelial cell inflammation was also inhibited by using a phospholipase C (PLC) inhibitor. The single nucleotide polymorphism rs6140791 was identified between PLCB4 and PLCB1 . Plasma PLC levels were higher in patients with KD and CC+CG rs6140791genotypes and these genotypes were more prevalent in patients with KD who also had CAA. Our results suggest that polymorphism of the PLCB4/B1 genes might be involved in the CAA pathogenesis of KD.

Type of Medium: Online Resource

ISSN: 2045-2322

URL: Article

DOI: 10.1038/srep14762

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2015

detail.hit.zdb_id: 2615211-3

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

BTU Cottbus

Wissenschaftspark Albert Einstein

EUV Frankfurt

TH Wildau

FH Potsdam

Online Resource

Association of human height-related genetic variants with familial short stature in Han Chinese in Taiwan

Lin, Ying-Ju ; Liao, Wen-Ling ; Wang, Chung-Hsing ; [et al.]

Springer Science and Business Media LLC ; 2017

In: Scientific Reports Vol. 7, No. 1 ( 2017-07-25)

add to watchlist on the watchlist

Details

In: Scientific Reports, Springer Science and Business Media LLC, Vol. 7, No. 1 ( 2017-07-25)

Abstract: Human height can be described as a classical and inherited trait model. Genome-wide association studies (GWAS) have revealed susceptible loci and provided insights into the polygenic nature of human height. Familial short stature (FSS) represents a suitable trait for investigating short stature genetics because disease associations with short stature have been ruled out in this case. In addition, FSS is caused only by genetically inherited factors. In this study, we explored the correlations of FSS risk with the genetic loci associated with human height in previous GWAS, alone and cumulatively. We systematically evaluated 34 known human height single nucleotide polymorphisms (SNPs) in relation to FSS in the additive model ( p 〈 0.00005). A cumulative effect was observed: the odds ratios gradually increased with increasing genetic risk score quartiles ( p 〈 0.001; Cochran-Armitage trend test). Six affected genes— ZBTB38 , ZNF638 , LCORL , CABLES1 , CDK10 , and TSEN15 —are located in the nucleus and have been implicated in embryonic, organismal, and tissue development. In conclusion, our study suggests that 13 human height GWAS-identified SNPs are associated with FSS risk both alone and cumulatively.

Type of Medium: Online Resource

ISSN: 2045-2322

URL: Article

DOI: 10.1038/s41598-017-06766-z

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2017

detail.hit.zdb_id: 2615211-3

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

BTU Cottbus

Wissenschaftspark Albert Einstein

EUV Frankfurt

TH Wildau

FH Potsdam

Online Resource

Association of Promoter Genetic Variants in Interleukin‐10 and Kawasaki Disease With Coronary Artery Aneurysms

Lin, Ying‐Ju ; Lan, Yu‐Ching ; Lai, Chih‐Ho ; [et al.]

Wiley ; 2014

In: Journal of Clinical Laboratory Analysis Vol. 28, No. 6 ( 2014-11), p. 461-464

add to watchlist on the watchlist

Details

In: Journal of Clinical Laboratory Analysis, Wiley, Vol. 28, No. 6 ( 2014-11), p. 461-464

Abstract: Kawasaki disease (KD) is an acute, self‐limited vasculitis in infants and young children. Interleukin‐10 (IL‐10) is a potent cytokine that exerts pleiotropic effects on immunoregulation and inflammation. Elevated IL‐10 serum levels have been reported in the KD patients. Methods In this study, we investigated whether IL‐10 genetic polymorphisms contribute to coronary artery aneurysm (CAA) development among KD patients in Taiwan. A total of 58 KD patients with CAA and 277 unrelated healthy children matched for sex and age were enrolled for this study. Results Higher G allele frequencies of IL‐10 at ‐1082 position were observed in KD patients with CAA compared to the controls ( P = 0.016, OR: 2.86, 95% CI, 1.17–6.98). In addition, higher IL‐10 GCC haplotype frequencies were also observed in KD patients with CAA ( P = 0.016, OR: 2.85, 95% CI, 1.17–6.98). Conclusion Our data support the possibility that IL‐10 gene polymorphisms may be related with CAA development of KD in Taiwanese population.

Type of Medium: Online Resource

ISSN: 0887-8013 , 1098-2825

URL: Issue

URL: Article

DOI: 10.1002/jcla.2014.28.issue-6

DOI: 10.1002/jcla.21710

Language: English

Publisher: Wiley

Publication Date: 2014

detail.hit.zdb_id: 2001635-9

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

BTU Cottbus

Wissenschaftspark Albert Einstein

EUV Frankfurt

TH Wildau

FH Potsdam

Online Resource

Genetic variants of glutamate receptor gene family in Taiwanese Kawasaki disease children with coronary artery aneurysms

Lin, Ying-Ju ; Chang, Jeng-Sheng ; Liu, Xiang ; [et al.]

Springer Science and Business Media LLC ; 2014

In: Cell & Bioscience Vol. 4, No. 1 ( 2014-12)

add to watchlist on the watchlist

Details

In: Cell & Bioscience, Springer Science and Business Media LLC, Vol. 4, No. 1 ( 2014-12)

Type of Medium: Online Resource

ISSN: 2045-3701

URL: Article

DOI: 10.1186/2045-3701-4-67

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2014

detail.hit.zdb_id: 2593367-X

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

BTU Cottbus

Wissenschaftspark Albert Einstein

EUV Frankfurt

TH Wildau

FH Potsdam

Online Resource

Coronary artery aneurysms occurrence risk analysis between Kawasaki disease and LRP1B gene in Taiwanese children

Lin, Ying-Ju ; Liu, Xiang ; Chang, Jeng-Sheng ; [et al.]

China Medical University ; 2014

In: BioMedicine Vol. 4, No. 2 ( 2014-6)

add to watchlist on the watchlist

Details

In: BioMedicine, China Medical University, Vol. 4, No. 2 ( 2014-6)

Type of Medium: Online Resource

ISSN: 2211-8039

URL: Article

DOI: 10.7603/s40681-014-0010-5

Language: English

Publisher: China Medical University

Publication Date: 2014

detail.hit.zdb_id: 2648006-2

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

BTU Cottbus

Wissenschaftspark Albert Einstein

EUV Frankfurt

TH Wildau

FH Potsdam

Online Resource

Variants in ZNRD1 Gene Predict HIV-1/AIDS Disease Progression in a Han Chinese Population in Taiwan

Lin, Ying-Ju ; Lan, Yu-Ching ; Hung, Chien-Hui ; [et al.]

Public Library of Science (PLoS) ; 2013

In: PLoS ONE Vol. 8, No. 7 ( 2013-7-9), p. e67572-

add to watchlist on the watchlist

Details

In: PLoS ONE, Public Library of Science (PLoS), Vol. 8, No. 7 ( 2013-7-9), p. e67572-

Type of Medium: Online Resource

ISSN: 1932-6203

URL: Article

DOI: 10.1371/journal.pone.0067572

DOI: 10.1371/journal.pone.0067572.g001

DOI: 10.1371/journal.pone.0067572.g002

DOI: 10.1371/journal.pone.0067572.t001

DOI: 10.1371/journal.pone.0067572.t002

DOI: 10.1371/journal.pone.0067572.s001

DOI: 10.1371/journal.pone.0067572.s002

DOI: 10.1371/journal.pone.0067572.s003

DOI: 10.1371/journal.pone.0067572.s004

Language: English

Publisher: Public Library of Science (PLoS)

Publication Date: 2013

detail.hit.zdb_id: 2267670-3

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

BTU Cottbus

Wissenschaftspark Albert Einstein

EUV Frankfurt

TH Wildau

FH Potsdam

Online Resource

Sorting nexin 24 genetic variation associates with coronary artery aneurysm severity in Kawasaki disease patients

Lin, Ying-Ju ; Chang, Jeng-Sheng ; Liu, Xiang ; [et al.]

Springer Science and Business Media LLC ; 2013

In: Cell & Bioscience Vol. 3, No. 1 ( 2013), p. 44-

add to watchlist on the watchlist

Details

In: Cell & Bioscience, Springer Science and Business Media LLC, Vol. 3, No. 1 ( 2013), p. 44-

Type of Medium: Online Resource

ISSN: 2045-3701

URL: Article

DOI: 10.1186/2045-3701-3-44

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2013

detail.hit.zdb_id: 2593367-X

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

BTU Cottbus

Wissenschaftspark Albert Einstein

EUV Frankfurt

TH Wildau

FH Potsdam

hits 1 - 10 | 294 hits

Nothing or not found what you are looking for? Please check your search query or use the Interlibrary Loan Search.

Kooperativer Bibliotheksverbund

Berlin Brandenburg