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1

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Continued optimization of the MLPCN probe ML071 into highly potent agonists of the hM1 muscarinic acetylcholine receptor

Melancon, Bruce J. ; Gogliotti, Rocco D. ; Tarr, James C. ; [et al.]

Elsevier BV ; 2012

In: Bioorganic & Medicinal Chemistry Letters Vol. 22, No. 10 ( 2012-5), p. 3467-3472

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In: Bioorganic & Medicinal Chemistry Letters, Elsevier BV, Vol. 22, No. 10 ( 2012-5), p. 3467-3472

Type of Medium: Online Resource

ISSN: 0960-894X

URL: Article

DOI: 10.1016/j.bmcl.2012.03.088

RVK:

VA 2620

Language: English

Publisher: Elsevier BV

Publication Date: 2012

detail.hit.zdb_id: 1501505-1

SSG: 15,3

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2

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PF-06827443 Displays Robust Allosteric Agonist and Positive Allosteric Modulator Activity in High Receptor Reserve and Native Systems

Moran, Sean P. ; Cho, Hyekyung P. ; Maksymetz, James ; [et al.]

American Chemical Society (ACS) ; 2018

In: ACS Chemical Neuroscience Vol. 9, No. 9 ( 2018-09-19), p. 2218-2224

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In: ACS Chemical Neuroscience, American Chemical Society (ACS), Vol. 9, No. 9 ( 2018-09-19), p. 2218-2224

Type of Medium: Online Resource

ISSN: 1948-7193 , 1948-7193

URL: Article

DOI: 10.1021/acschemneuro.8b00106

DOI: 10.1021/acschemneuro.8b00106.s001

Language: English

Publisher: American Chemical Society (ACS)

Publication Date: 2018

detail.hit.zdb_id: 2528493-9

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3

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Development of a highly selective, orally bioavailable and CNS penetrant M1 agonist derived from the MLPCN probe ML071

Lebois, Evan P. ; Digby, Gregory J. ; Sheffler, Douglas J. ; [et al.]

Elsevier BV ; 2011

In: Bioorganic & Medicinal Chemistry Letters Vol. 21, No. 21 ( 2011-11), p. 6451-6455

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In: Bioorganic & Medicinal Chemistry Letters, Elsevier BV, Vol. 21, No. 21 ( 2011-11), p. 6451-6455

Type of Medium: Online Resource

ISSN: 0960-894X

URL: Article

DOI: 10.1016/j.bmcl.2011.08.084

RVK:

VA 2620

Language: English

Publisher: Elsevier BV

Publication Date: 2011

detail.hit.zdb_id: 1501505-1

SSG: 15,3

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4

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Design and Synthesis of Systemically Active Metabotropic Glutamate Subtype-2 and -3 (mGlu 2/3 ) Receptor Positive Allosteric Modulators (PAMs): Pharmacological Characterization and Assessment in a Rat Model of Cocaine Dependence

Dhanya, Raveendra-Panickar ; Sheffler, Douglas J. ; Dahl, Russell ; [et al.]

American Chemical Society (ACS) ; 2014

In: Journal of Medicinal Chemistry Vol. 57, No. 10 ( 2014-05-22), p. 4154-4172

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In: Journal of Medicinal Chemistry, American Chemical Society (ACS), Vol. 57, No. 10 ( 2014-05-22), p. 4154-4172

Type of Medium: Online Resource

ISSN: 0022-2623 , 1520-4804

URL: Article

DOI: 10.1021/jm5000563

Language: English

Publisher: American Chemical Society (ACS)

Publication Date: 2014

detail.hit.zdb_id: 1491411-6

SSG: 15,3

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5

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M1-positive allosteric modulators lacking agonist activity provide the optimal profile for enhancing cognition

Moran, Sean P. ; Dickerson, Jonathan W. ; Cho, Hyekyung P. ; [et al.]

Springer Science and Business Media LLC ; 2018

In: Neuropsychopharmacology Vol. 43, No. 8 ( 2018-7), p. 1763-1771

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In: Neuropsychopharmacology, Springer Science and Business Media LLC, Vol. 43, No. 8 ( 2018-7), p. 1763-1771

Type of Medium: Online Resource

ISSN: 0893-133X , 1740-634X

URL: Article

DOI: 10.1038/s41386-018-0033-9

RVK:

WA 15000

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2018

detail.hit.zdb_id: 2008300-2

SSG: 15,3

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6

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A Novel M1 PAM VU0486846 Exerts Efficacy in Cognition Models without Displaying Agonist Activity or Cholinergic Toxicity

Rook, Jerri M. ; Bertron, Jeanette L. ; Cho, Hyekyung P. ; [et al.]

American Chemical Society (ACS) ; 2018

In: ACS Chemical Neuroscience Vol. 9, No. 9 ( 2018-09-19), p. 2274-2285

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In: ACS Chemical Neuroscience, American Chemical Society (ACS), Vol. 9, No. 9 ( 2018-09-19), p. 2274-2285

Type of Medium: Online Resource

ISSN: 1948-7193 , 1948-7193

URL: Article

DOI: 10.1021/acschemneuro.8b00131

DOI: 10.1021/acschemneuro.8b00131.s001

Language: English

Publisher: American Chemical Society (ACS)

Publication Date: 2018

detail.hit.zdb_id: 2528493-9

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7

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Activation of the mGlu1 metabotropic glutamate receptor has antipsychotic-like effects and is required for efficacy of M4 muscarinic receptor allosteric modulators

Yohn, Samantha E. ; Foster, Daniel J. ; Covey, Dan P. ; [et al.]

Springer Science and Business Media LLC ; 2020

In: Molecular Psychiatry Vol. 25, No. 11 ( 2020-11), p. 2786-2799

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In: Molecular Psychiatry, Springer Science and Business Media LLC, Vol. 25, No. 11 ( 2020-11), p. 2786-2799

Type of Medium: Online Resource

ISSN: 1359-4184 , 1476-5578

URL: Article

DOI: 10.1038/s41380-018-0206-2

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2020

detail.hit.zdb_id: 1502531-7

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8

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Prefrontal Cortex-Mediated Impairments in a Genetic Model of NMDA Receptor Hypofunction Are Reversed by the Novel M1 PAM VU6004256

Grannan, Michael D. ; Mielnik, Catharine A. ; Moran, Sean P. ; [et al.]

American Chemical Society (ACS) ; 2016

In: ACS Chemical Neuroscience Vol. 7, No. 12 ( 2016-12-21), p. 1706-1716

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In: ACS Chemical Neuroscience, American Chemical Society (ACS), Vol. 7, No. 12 ( 2016-12-21), p. 1706-1716

Type of Medium: Online Resource

ISSN: 1948-7193 , 1948-7193

URL: Article

DOI: 10.1021/acschemneuro.6b00230

DOI: 10.1021/acschemneuro.6b00230.s001

Language: English

Publisher: American Chemical Society (ACS)

Publication Date: 2016

detail.hit.zdb_id: 2528493-9

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9

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Challenges in the development of an M 4 PAM preclinical candidate: The discovery, SAR, and biological characterization of a series of azetidine-derived tertiary amides

Tarr, James C. ; Wood, Michael R. ; Noetzel, Meredith J. ; [et al.]

Elsevier BV ; 2017

In: Bioorganic & Medicinal Chemistry Letters Vol. 27, No. 23 ( 2017-12), p. 5179-5184

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In: Bioorganic & Medicinal Chemistry Letters, Elsevier BV, Vol. 27, No. 23 ( 2017-12), p. 5179-5184

Type of Medium: Online Resource

ISSN: 0960-894X

URL: Article

DOI: 10.1016/j.bmcl.2017.10.053

RVK:

VA 2620

Language: English

Publisher: Elsevier BV

Publication Date: 2017

detail.hit.zdb_id: 1501505-1

SSG: 15,3

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10

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Further exploration of M1 allosteric agonists: Subtle structural changes abolish M1 allosteric agonism and result in pan-mAChR orthosteric antagonism

Sheffler, Douglas J. ; Sevel, Christian ; Le, Uyen ; [et al.]

Elsevier BV ; 2013

In: Bioorganic & Medicinal Chemistry Letters Vol. 23, No. 1 ( 2013-01), p. 223-227

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In: Bioorganic & Medicinal Chemistry Letters, Elsevier BV, Vol. 23, No. 1 ( 2013-01), p. 223-227

Type of Medium: Online Resource

ISSN: 0960-894X

URL: Article

DOI: 10.1016/j.bmcl.2012.10.132

RVK:

VA 2620

Language: English

Publisher: Elsevier BV

Publication Date: 2013

detail.hit.zdb_id: 1501505-1

SSG: 15,3

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