In:
Journal of Gastroenterology and Hepatology, Wiley, Vol. 30, No. 1 ( 2015-01), p. 139-146
Abstract:
Lifestyle modification is the cornerstone for the management of nonalcoholic fatty liver disease ( NAFLD ), and patatin‐like phospholipase 3 ( PNPLA 3 ) is one of the most important genetic determinants of NAFLD . We aimed to investigate the effect of PNPLA 3 gene polymorphism on the response to lifestyle modification in NAFLD patients. Methods This was a post‐hoc analysis of a randomized controlled trial on a lifestyle modification program in community NAFLD patients. The PNPLA 3 rs738409 gene polymorphism was correlated with changes in metabolic profile and intrahepatic triglyceride content ( IHTG ) as measured by proton magnetic resonance spectroscopy. Results One hundred and fifty‐four patients were equally randomized into the intervention and control groups. The presence of G allele was associated with greater reduction in IHTG ( CC : 3.7 ± 5.2%, CG : 6.5 ± 3.6%), and GG : 11.3 ± 8.8% ( S pearman's correlation, 0.34; P = 0.002), body weight ( P = 0.030), waist‐to‐hip ratio ( P = 0.024), total cholesterol ( P = 0.031), and low‐density lipoprotein cholesterol ( P = 0.009) in the intervention group. In contrast, PNPLA 3 polymorphism had no impact on IHTG changes in the control group. By multivariable analysis, PNPLA 3 genotype and body mass index ( BMI ) change were independently associated with IHTG reduction in the intervention group. Only BMI change was associated with IHTG reduction in the control group. Conclusion Although the PNPLA 3 rs738409 GG genotype confers a higher risk of NAFLD , these patients are more sensitive to the beneficial effects of lifestyle modification and should be encouraged to do so.
Type of Medium:
Online Resource
ISSN:
0815-9319
,
1440-1746
DOI:
10.1111/jgh.2015.30.issue-1
Language:
English
Publisher:
Wiley
Publication Date:
2015
detail.hit.zdb_id:
2006782-3
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