In:
PLOS ONE, Public Library of Science (PLoS), Vol. 15, No. 11 ( 2020-11-30), p. e0242785-
Abstract:
Loss of body weight is often seen in pancreatic cancer and also predicts poor prognosis. Thus, maintaining muscle mass is an essential treatment goal. The primary aim was to investigate whether progressive resistance training impacts muscle and adipose tissue compartments. Furthermore, the effect of body composition on overall survival (OS) was investigated. Methods In the randomized SUPPORT-study, 65 patients were assigned to 6-month resistance training (2x/week) or a usual care control group. As secondary endpoint, muscle strength of the upper and lower extremities was assessed before and after the intervention period. Routine CT scans were assessed on lumbar L3/4 level for quantification of total-fat-area, visceral-fat-area, subcutaneous-fat-area, intramuscular-fat-area, visceral-to-subcutaneous fat ratio (VFR), muscle-area (MA), muscle-density and skeletal-muscle-index (SMI). OS data were retrieved. Results Of 65 patients, 53 had suitable CT scans at baseline and 28 completed the intervention period with suitable CT scans. There were no significant effects observed of resistance training on body composition (p 〉 0.05; effect sizes ω 2 p 〈 0.02). Significant moderate to high correlations were found between MA and muscle strength parameters (r = 0.57–0.85; p 〈 0.001). High VFR at baseline was a predictor of poor OS (VFR≥1.3 vs. 〈 1.3; median OS 14.6 vs. 45.3 months; p = 0.012). Loss of muscle mass was also a predictor of poor OS (loss vs. gain of SMI; median OS 24.6 vs. 50.8 months; p = 0.049). Conclusion There is anabolic potential in patients with resectable pancreatic cancer. A progressive resistance training may help patients to maintain their muscle mass and avoid muscle depletion. CT-quantified muscle mass at the level of L3/4 showed a good correlation to muscle strength. Therefore, maintaining muscle mass and muscle strength through structured resistance training could help patients to maintain their physical functioning. A high VFR at baseline and a high loss of muscle mass are predictors of poor OS. Registered on ClinicalTrials.gov (NCT01977066).
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0242785
DOI:
10.1371/journal.pone.0242785.g001
DOI:
10.1371/journal.pone.0242785.g002
DOI:
10.1371/journal.pone.0242785.g003
DOI:
10.1371/journal.pone.0242785.t001
DOI:
10.1371/journal.pone.0242785.t002
DOI:
10.1371/journal.pone.0242785.t003
DOI:
10.1371/journal.pone.0242785.t004
DOI:
10.1371/journal.pone.0242785.t005
DOI:
10.1371/journal.pone.0242785.t006
DOI:
10.1371/journal.pone.0242785.s001
DOI:
10.1371/journal.pone.0242785.s002
DOI:
10.1371/journal.pone.0242785.s003
DOI:
10.1371/journal.pone.0242785.s004
DOI:
10.1371/journal.pone.0242785.s005
DOI:
10.1371/journal.pone.0242785.r001
DOI:
10.1371/journal.pone.0242785.r002
DOI:
10.1371/journal.pone.0242785.r003
DOI:
10.1371/journal.pone.0242785.r004
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2020
detail.hit.zdb_id:
2267670-3
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