In:
Nature Communications, Springer Science and Business Media LLC, Vol. 8, No. 1 ( 2017-12-01)
Abstract:
Several susceptibility loci for classical Hodgkin lymphoma have been reported. However, much of the heritable risk is unknown. Here, we perform a meta-analysis of two existing genome-wide association studies, a new genome-wide association study, and replication totalling 5,314 cases and 16,749 controls. We identify risk loci for all classical Hodgkin lymphoma at 6q22.33 (rs9482849 , P = 1.52 × 10 −8 ) and for nodular sclerosis Hodgkin lymphoma at 3q28 (rs4459895, P = 9.43 × 10 −17 ), 6q23.3 (rs6928977, P = 4.62 × 10 −11 ), 10p14 (rs3781093, P = 9.49 × 10 −13 ), 13q34 (rs112998813, P = 4.58 × 10 −8 ) and 16p13.13 (rs34972832 , P = 2.12 × 10 −8 ). Additionally, independent loci within the HLA region are observed for nodular sclerosis Hodgkin lymphoma (rs9269081, HLA-DPB1*03:01, Val86 in HLA-DRB1) and mixed cellularity Hodgkin lymphoma (rs1633096, rs13196329, Val86 in HLA-DRB1). The new and established risk loci localise to areas of active chromatin and show an over-representation of transcription factor binding for determinants of B-cell development and immune response.
Type of Medium:
Online Resource
ISSN:
2041-1723
DOI:
10.1038/s41467-017-00320-1
Language:
English
Publisher:
Springer Science and Business Media LLC
Publication Date:
2017
detail.hit.zdb_id:
2553671-0
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