In:
Frontiers in Transplantation, Frontiers Media SA, Vol. 1 ( 2022-12-19)
Abstract:
There is no consensus on how to predict post-transplant function of donation after circulatory death ( DCD ) kidneys. Thus, we aimed to identify renal scintigraphy parameters that could predict 1-year kidney function. Methods In this single center study, we included all consecutive DCD kidney recipients between 2013 and 2021 ( n = 29). Patients who did not have a scintigraphy within 10 days of transplantation ( n = 3), recipients of multiple organs and less than 18 years old were excluded ( n = 1). Primary endpoint was the estimated glomerular filtration rate (eGFR). Results Median eGFR and serum creatinine at 1 year were 67 µmol/L (56–81) and 111 ml/min (99–132), respectively. Among parameters tested, the 3 rd /2 nd -minute activity ratio had the best diagnostic performance (AUC: 0.74 and 0.71, for eGFR and creatinine) 1 year post transplantation. Using 1.21 as the best cut off, the 3 rd /2 nd -minute activity ratio specificity and sensitivity to predict eGFR & gt;60 ml/min was 0.82 and 0.83. Renal function was significantly better at 1 week, 3, 6, and 12 months after transplantation in patients with 3 rd /2 nd -minute activity ratios above 1.21. Conclusion This study suggests that the 3 rd /2 nd -minute activity ratio can predict graft function at 1 year. The benefit of post-transplant scintigraphy should be further validated in a prospective cohort.
Type of Medium:
Online Resource
ISSN:
2813-2440
DOI:
10.3389/frtra.2022.1065415
DOI:
10.3389/frtra.2022.1065415.s001
Language:
Unknown
Publisher:
Frontiers Media SA
Publication Date:
2022
detail.hit.zdb_id:
3139447-4
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