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  • 1
    Online Resource
    Online Resource
    AIP Publishing ; 2022
    In:  Biomicrofluidics Vol. 16, No. 6 ( 2022-12-01)
    In: Biomicrofluidics, AIP Publishing, Vol. 16, No. 6 ( 2022-12-01)
    Abstract: The liver is the largest internal organ in the human body with largest mass of glandular tissue. Modeling the liver has been challenging due to its variety of major functions, including processing nutrients and vitamins, detoxification, and regulating body metabolism. The intrinsic shortfalls of conventional two-dimensional (2D) cell culture methods for studying pharmacokinetics in parenchymal cells (hepatocytes) have contributed to suboptimal outcomes in clinical trials and drug development. This prompts the development of highly automated, biomimetic liver-on-a-chip (LOC) devices to simulate native liver structure and function, with the aid of recent progress in microfluidics. LOC offers a cost-effective and accurate model for pharmacokinetics, pharmacodynamics, and toxicity studies. This review provides a critical update on recent developments in designing LOCs and fabrication strategies. We highlight biomimetic design approaches for LOCs, including mimicking liver structure and function, and their diverse applications in areas such as drug screening, toxicity assessment, and real-time biosensing. We capture the newest ideas in the field to advance the field of LOCs and address current challenges.
    Type of Medium: Online Resource
    ISSN: 1932-1058
    Language: English
    Publisher: AIP Publishing
    Publication Date: 2022
    detail.hit.zdb_id: 2265444-6
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  • 2
    In: International Journal of Bioprinting, AccScience Publishing, Vol. 9, No. 4 ( 2023-04-26), p. 0-
    Abstract: Three-dimensional printing (3DP) is a popular manufacturing technique with versatile potential for materials processing in tissue engineering and regenerative medicine. In particular, the repair and regeneration of significant bone defects remain as substantial clinical challenges that require biomaterial implants to maintain mechanical strength and porosity, which may be realized using 3DP. The rapid progress in 3DP development in the past decade warrants a bibliometric analysis to gain insights into its applications in bone tissue engineering (BTE). Here, we performed a comparative study using bibliometric methods for 3DP in bone repair and regeneration. A total of 2,025 articles were included, and the results showed an increase in the number of publications and relative research interest on 3DP annually worldwide. China was the leader in international cooperation in this field and also the largest contributor to the number of citations. The majority of articles in this field were published in the journal Biofabrication. Chen Y was the author who made the highest contribution to the included studies. The keywords included in the publications were mainly related to BTE and regenerative medicine (including & ldquo;3DP techniques, & rdquo; & ldquo;3DP materials, & rdquo; & ldquo;bone regeneration strategies, & rdquo; and & ldquo;bone disease therapeutics & rdquo;) for bone regeneration and repair. This bibliometric and visualized analysis provides significant insights into the historical development of 3DP in BTE from 2012 to 2022, which will be beneficial for scientists to conduct further investigations into this dynamic field. & nbsp;
    Type of Medium: Online Resource
    ISSN: 2424-7723 , 2424-8002
    Language: Unknown
    Publisher: AccScience Publishing
    Publication Date: 2023
    detail.hit.zdb_id: 2834694-4
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