In:
World Journal of Surgical Oncology, Springer Science and Business Media LLC, Vol. 19, No. 1 ( 2021-12)
Abstract:
The main negative prognostic factors in patients with rectal cancer after radical treatment include regional lymph node involvement, lymphovascular invasion, and perineural invasion. However, some patients still develop cancer recurrence despite the absence of the above risk factors. The aim of the study was to assess clinicopathological factors influencing long-term oncologic outcomes in ypN0M0 rectal cancer patients after neoadjuvant therapy and radical anterior resection. Methods A retrospective survival analysis was performed on a group of 195 patients. We assessed clinicopathological factors which included tumor regression grade, number of lymph nodes in the specimen, Charlson comorbidity index (CCI), and colorectal anastomotic leakage (AL). Results In the univariate analysis, AL and CCI 〉 3 had a significant negative impact on disease-free survival (DFS), disease-specific survival (DSS), and overall survival (OS). After the division of ALs into early and late ALs, it was found that only patients with late ALs had a significantly worse survival. The multivariate Cox regression analysis showed that CCI 〉 3 was a significant adverse risk factor for DFS (HR 5.78, 95% CI 2.15–15.51, p 〈 0.001), DSS (HR 7.25, 95% CI 2.25–23.39, p 〈 0.001), and OS (HR 3.9, 95% CI 1.72–8.85, p = 0.001). Similarly, late ALs had a significant negative impact on the risk of DFS (HR 5.05, 95% CI 1.97–12.93, p 〈 0.001), DSS (HR 10.84, 95% CI 3.44–34.18, p 〈 0.001), and OS (HR 4.3, 95% CI 1.94–9.53, p 〈 0.001). Conclusions Late AL and CCI 〉 3 are the factors that may have an impact on long-term oncologic outcomes. The impact of lymph node yield on understaging was not demonstrated.
Type of Medium:
Online Resource
ISSN:
1477-7819
DOI:
10.1186/s12957-021-02262-x
Language:
English
Publisher:
Springer Science and Business Media LLC
Publication Date:
2021
detail.hit.zdb_id:
2118383-1
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