In:
International Journal of Cancer, Wiley, Vol. 145, No. 9 ( 2019-11), p. 2568-2579
Abstract:
What's new? Oral squamous cell carcinoma (OSCC) is a significant cause of cancer‐related morbidity and mortality. OSCC outcome may be predicted by lymph node (LN) metastasis, though this requires careful clinico‐radiological evaluation to avoid false inferences. Here, to improve LN evaluation, the authors identified and correlated genomic alterations in OSCC with pathological nodal stage. Comparison of exome sequences with copy number variations in blood and tumor DNA revealed associations between LN metastasis and chromosomal instability, DNA repair defects, and mutations in various biological pathways. Mutations in the mito‐G2/M pathway, BRCA2 , the NHEJ pathway, FAT1 , and CASP8 were highly predictive of LN metastasis.
Type of Medium:
Online Resource
ISSN:
0020-7136
,
1097-0215
Language:
English
Publisher:
Wiley
Publication Date:
2019
detail.hit.zdb_id:
218257-9
detail.hit.zdb_id:
1474822-8
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