In:
Photodermatology, Photoimmunology & Photomedicine, Wiley, Vol. 35, No. 5 ( 2019-09), p. 344-353
Abstract:
The inter‐individual variation in 25(OH)D 3 increase (Δ25(OH)D 3 ) after vitamin D 3 supplementation was determined and compared with the UVB irradiation response. Methods Nineteen Danish participants received 85 μg vitamin D 3 (cholecalciferol) daily for nine weeks with regular serum 25(OH)D 3 measurements. These participants had three years earlier taken part in a 9‐week controlled UVB study. The Δ25(OH)D 3 was not confounded by ambient UVB, BMI or ethnicity. Results Δ25(OH)D 3 was 53 nmol L −1 and almost identical to Δ25(OH)D 3 (52 nmol L −1 ) after UVB. Δ25(OH)D 3 ranged from 17 to 91 nmol L −1 (span 74 nmol L −1 ) and was about half of that observed after UVB irradiation (span 136 nmol L −1 ). The interquartile ranges for vitamin D 3 supplementation (38.8‐71.4 nmol L −1 , span: 32.6 nmol L −1 ) and UVB irradiation (35.7‐65.4 nmol L −1 , span: 29.7 nmol L −1 ) were similar indicating a comparable response of the two interventions. As the 25(OH)D 3 start levels ( R 2 = 0.398, P = 3.8 × 10 −3 ), 25(OH)D 3 end levels ( R 2 = 0.457, P = 1.5 × 10 −3 ) and Δ25(OH)D 3 ( R 2 = 0.253, P = 0.028) between both interventions were correlated, this suggested a possible common individual background for the variation. Four pigment SNPs influenced the variation in the vitamin D 3 ‐induced and UVB‐induced Δ25(OH)D 3 . A combined model including the influence of these four SNPs and the 25(OH)D 3 start level explained 86.8% ( P = 1.6 × 10 −35 ) of the individual variation after vitamin D 3 supplementation. Conclusion The inter‐individual variation in the two interventions was comparable and had no common demographic but a partly common genetic background.
Type of Medium:
Online Resource
ISSN:
0905-4383
,
1600-0781
Language:
English
Publisher:
Wiley
Publication Date:
2019
detail.hit.zdb_id:
2026222-X
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