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Immunogenicity of SARS-CoV-2 vaccines BBV152 (COVAXIN®) and ChAdOx1 nCoV-19 (COVISHIELD™) in seronegative and seropositive individuals in India: a multicentre, nonrandomised observational study

Asokan, Mangaiarkarasi S. ; Joan, Roshni Florina ; Babji, Sudhir ; [et al.]

Elsevier BV ; 2024

In: The Lancet Regional Health - Southeast Asia Vol. 22 ( 2024-03), p. 100361-

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In: The Lancet Regional Health - Southeast Asia, Elsevier BV, Vol. 22 ( 2024-03), p. 100361-

Type of Medium: Online Resource

ISSN: 2772-3682

URL: Article

DOI: 10.1016/j.lansea.2024.100361

Language: English

Publisher: Elsevier BV

Publication Date: 2024

detail.hit.zdb_id: 3128823-6

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Seroprevalence of SARS-CoV-2 specific Immunoglobin G antibodies in rural population of Western Maharashtra, India

Agarwal, Dhiraj ; Patil, Rutuja ; Roy, Sudipto ; [et al.]

International Society of Global Health ; 2023

In: Journal of Global Health Vol. 13 ( 2023-04-21)

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In: Journal of Global Health, International Society of Global Health, Vol. 13 ( 2023-04-21)

Type of Medium: Online Resource

ISSN: 2047-2978 , 2047-2986

URL: Article

DOI: 10.7189/jogh.13.06011

Language: English

Publisher: International Society of Global Health

Publication Date: 2023

detail.hit.zdb_id: 2741629-X

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Immunogenicity and lot-to-lot consistency of a ready to use liquid bovine-human reassortant pentavalent rotavirus vaccine (ROTASIIL - Liquid) in Indian infants

Kawade, Anand ; Babji, Sudhir ; Kamath, Veena ; [et al.]

Elsevier BV ; 2019

In: Vaccine Vol. 37, No. 19 ( 2019-05), p. 2554-2560

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In: Vaccine, Elsevier BV, Vol. 37, No. 19 ( 2019-05), p. 2554-2560

Type of Medium: Online Resource

ISSN: 0264-410X

URL: Article

DOI: 10.1016/j.vaccine.2019.03.067

Language: English

Publisher: Elsevier BV

Publication Date: 2019

detail.hit.zdb_id: 1468474-3

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Assessment of risk of intussusception after pilot rollout of rotavirus vaccine in the Indian public health system

Bhandari, Nita ; Antony, Kalpana ; Balraj, Vinohar ; [et al.]

Elsevier BV ; 2020

In: Vaccine Vol. 38, No. 33 ( 2020-07), p. 5241-5248

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In: Vaccine, Elsevier BV, Vol. 38, No. 33 ( 2020-07), p. 5241-5248

Type of Medium: Online Resource

ISSN: 0264-410X

URL: Article

DOI: 10.1016/j.vaccine.2020.05.093

Language: English

Publisher: Elsevier BV

Publication Date: 2020

detail.hit.zdb_id: 1468474-3

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Conducting community-based pediatric research in rural India: Experience from vadu rural health program

Apte, Aditi ; Dayma, Girish ; Lubree, Himangi ; [et al.]

Medknow ; 2021

In: Perspectives in Clinical Research Vol. 12, No. 3 ( 2021), p. 126-

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In: Perspectives in Clinical Research, Medknow, Vol. 12, No. 3 ( 2021), p. 126-

Type of Medium: Online Resource

ISSN: 2229-3485

URL: Article

DOI: 10.4103/picr.picr_325_20

Language: English

Publisher: Medknow

Publication Date: 2021

detail.hit.zdb_id: 2593231-7

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Feasibility and acceptability of the paediatric pulse oximeter in integrated management of neonatal and childhood illnesses (IMNCI) services by public health facilities: A qualitative study in rural Western India

Agarwal, Dhiraj ; Gore, Manisha ; Kawade, Anand ; [et al.]

International Society of Global Health ; 2023

In: Journal of Global Health Vol. 13 ( 2023-09-15)

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In: Journal of Global Health, International Society of Global Health, Vol. 13 ( 2023-09-15)

Type of Medium: Online Resource

ISSN: 2047-2978 , 2047-2986

URL: Article

DOI: 10.7189/jogh.13.04105

Language: English

Publisher: International Society of Global Health

Publication Date: 2023

detail.hit.zdb_id: 2741629-X

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Assessment of perceived distress due to nasopharyngeal swab collection in healthy Indian infants participating in a clinical trial

Kawade, Anand ; Dayma, Girish ; Apte, Aditi ; [et al.]

Wiley ; 2021

In: Paediatric and Neonatal Pain Vol. 3, No. 4 ( 2021-12), p. 170-175

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In: Paediatric and Neonatal Pain, Wiley, Vol. 3, No. 4 ( 2021-12), p. 170-175

Abstract: Routinely children are exposed to various procedures as a part of clinical care and/or research participation. Public health strategies to contain current COVID‐19 pandemic demanded massive nasopharyngeal swab testing but limited data exist to confirm the extent of the pain and distress that result from this procedure. These data could help clinicians to formulate mitigation strategies, influence public health directives, and inform review boards/ethics committees to decide on risk‐benefit ratio of the procedure. Hence, an observational study to assess perceived distress was nested in a phase IV alternate and reduced dose schedule trial of the pneumococcal conjugate vaccine (PCV) in which nasopharyngeal swab (NPS) was used to collect nasopharyngeal secretions as part of the study procedure. Out of 805 infant participants enrolled in the main study, a total of 425 infants were enrolled and observed for procedural distress at 18 weeks and 10 months of age using the Face Leg Activity Cry and Consolability (FLACC) Scale. The FLACC score and duration of cry were recorded. The mean FLACC score changed substantially from preprocedural to procedure in both age groups (from 0.08 to 5.8 at 18 weeks and from 0.5 to 7.007 at 10 months. P = 〈 .0001). The proportion of infants experiencing higher FLACC scores (7‐10) indicating severe distress increased significantly from 22% (n = 95) at 18 weeks to 61% (n = 248) at 10 months ( P 〈 .0001). The mean duration of cry was significantly increased from 23.03 seconds at 18 weeks to 52.6 seconds at 10 months ( P = .00). Nasopharyngeal swab collection produced substantial distress which increased with age. Adequate training of sample collectors and supporting parent engagement during procedure could help in reducing the distress.

Type of Medium: Online Resource

ISSN: 2637-3807 , 2637-3807

URL: Article

DOI: 10.1002/pne2.12068

Language: English

Publisher: Wiley

Publication Date: 2021

detail.hit.zdb_id: 2947561-2

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Effect of reduced two-dose (1+1) schedule of 10 and 13-valent pneumococcal conjugate vaccines (SynflorixTM and Prevenar13TM)) on nasopharyngeal carriage and serotype-specific immune response in the first two years of life: Results from an open-labelled randomized controlled trial in Indian children

Kawade, Anand ; Dayma, Girish ; Apte, Aditi ; [et al.]

Elsevier BV ; 2023

In: Vaccine Vol. 41, No. 19 ( 2023-05), p. 3066-3079

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In: Vaccine, Elsevier BV, Vol. 41, No. 19 ( 2023-05), p. 3066-3079

Type of Medium: Online Resource

ISSN: 0264-410X

URL: Article

DOI: 10.1016/j.vaccine.2023.04.008

Language: English

Publisher: Elsevier BV

Publication Date: 2023

detail.hit.zdb_id: 1468474-3

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Determinants of maternal influenza vaccination in the context of low- and middle-income countries: A systematic review

Raut, Shrish ; Apte, Aditi ; Srinivasan, Manikandan ; [et al.]

Public Library of Science (PLoS) ; 2022

In: PLOS ONE Vol. 17, No. 1 ( 2022-1-26), p. e0262871-

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In: PLOS ONE, Public Library of Science (PLoS), Vol. 17, No. 1 ( 2022-1-26), p. e0262871-

Abstract: Pregnancy and early infancy are considered to be the vulnerable phases for severe influenza infection causing morbidity and mortality. Despite WHO recommendations, influenza is not included in the immunization programs of many low- and middle-income countries. This systematic review is aimed at identifying barriers and facilitators for maternal influenza vaccination amongst the perinatal women and their health care providers in low- and middle-income countries. Methods We selected 11 studies from the 1669 records identified from PubMed, CABI, EMBASE and Global Health databases. Studies related to both pandemic and routine influenza vaccination and studies conducted amongst women in the antenatal as well as postnatal period were included. Both qualitative, quantitative, cross-sectional and interventional studies were included. Results Knowledge about influenza disease, perception of the disease severity during pregnancy and risk to the foetus/newborn and perceived benefits of influenza vaccination during pregnancy were associated with increased uptake of influenza vaccination during pregnancy. Recommendation by health care provider, vaccination in previous pregnancy and availability of vaccine in public health system facilitated vaccine uptake. High parity, higher education, vaccination in the later months of pregnancy, less than 4 antenatal visits, concerns about vaccine safety and negative publicity in media were identified as barriers for influenza vaccination. Lack of government recommendation, concerns about safety and effectiveness and distrust in manufacturer were the barriers for the healthcare providers to recommend vaccination. Conclusion While availability of influenza vaccine in public health system can be a key to the success of vaccine implementation program, increasing the awareness about need and benefits of maternal influenza vaccination amongst pregnant women as well as their health care providers is crucial to improve the acceptance of maternal influenza vaccination in low and middle-income countries.

Type of Medium: Online Resource

ISSN: 1932-6203

URL: Article

DOI: 10.1371/journal.pone.0262871

DOI: 10.1371/journal.pone.0262871.g001

DOI: 10.1371/journal.pone.0262871.t001

DOI: 10.1371/journal.pone.0262871.t002

DOI: 10.1371/journal.pone.0262871.t003

DOI: 10.1371/journal.pone.0262871.t004

DOI: 10.1371/journal.pone.0262871.s001

DOI: 10.1371/journal.pone.0262871.s002

DOI: 10.1371/journal.pone.0262871.s003

DOI: 10.1371/journal.pone.0262871.s004

DOI: 10.1371/journal.pone.0262871.r001

DOI: 10.1371/journal.pone.0262871.r002

DOI: 10.1371/journal.pone.0262871.r003

DOI: 10.1371/journal.pone.0262871.r004

DOI: 10.1371/journal.pone.0262871.r005

DOI: 10.1371/journal.pone.0262871.r006

Language: English

Publisher: Public Library of Science (PLoS)

Publication Date: 2022

detail.hit.zdb_id: 2267670-3

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A Phase 3, randomized, non-inferiority study of a heterologous booster dose of SARS CoV-2 recombinant spike protein vaccine in adults

Kulkarni, Prasad S. ; Gunale, Bhagwat ; Kohli, Sunil ; [et al.]

Springer Science and Business Media LLC ; 2023

In: Scientific Reports Vol. 13, No. 1 ( 2023-10-03)

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In: Scientific Reports, Springer Science and Business Media LLC, Vol. 13, No. 1 ( 2023-10-03)

Abstract: Due to waning immunity following primary immunization with COVID-19 vaccines, booster doses may be required. The present study assessed a heterologous booster of SII-NVX-CoV2373 (spike protein vaccine) in adults primed with viral vector and inactivated vaccines. In this Phase 3, observer-blind, randomized, active controlled study, a total of 372 adults primed with two doses of ChAdOx1 nCoV-19 (n = 186) or BBV152 (n = 186) at least six months ago, were randomized to receive a booster of SII-NVX-CoV2373 or control vaccine (homologous booster of ChAdOx1 nCoV-19 or BBV152). Anti-S IgG and neutralizing antibodies (nAbs) were assessed at days 1, 29, and 181. Non-inferiority (NI) of SII-NVX-CoV2373 to the control vaccine was assessed based on the ratio of geometric mean ELISA units (GMEU) of anti-S IgG and geometric mean titers (GMT) of nAbs (NI margin 〉 0.67) as well as seroresponse (≥ 2 fold-rise in titers) (NI margin −10%) at day 29. Safety was assessed throughout the study period. In both the ChAdOx1 nCoV-19 prime and BBV152 prime cohorts, 186 participants each received the study vaccines. In the ChAdOx1 nCoV-19 prime cohort, the GMEU ratio was 2.05 (95% CI 1.73, 2.43) and the GMT ratio was 1.89 (95% CI 1.55, 2.32) whereas the difference in the proportion of seroresponse was 49.32% (95% CI 36.49, 60.45) for anti-S IgG and 15% (95% CI 5.65, 25.05) for nAbs on day 29. In the BBV152 prime cohort, the GMEU ratio was 5.12 (95% CI 4.20, 6.24) and the GMT ratio was 4.80 (95% CI 3.76, 6.12) whereas the difference in the proportion of seroresponse was 74.08% (95% CI 63.24, 82.17) for anti-S IgG and 24.71% (95% CI 16.26, 34.62) for nAbs on day 29. The non-inferiority of SII-NVX-CoV2373 booster to the control vaccine for each prime cohort was met. SII-NVX-CoV2373 booster showed significantly higher immune responses than BBV152 homologous booster. On day 181, seroresponse rates were ≥ 70% in all the groups for both nAbs and anti-S IgG. Solicited adverse events reported were transient and mostly mild in severity in all the groups. No causally related SAE was reported. SII-NVX-CoV2373 as a heterologous booster induced non-inferior immune responses as compared to homologous boosters in adults primed with ChAdOx1 nCoV-19 and BBV152. SII-NVX-CoV2373 showed a numerically higher boosting effect than homologous boosters. The vaccine was also safe and well tolerated.

Type of Medium: Online Resource

ISSN: 2045-2322

URL: Article

DOI: 10.1038/s41598-023-43578-w

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2023

detail.hit.zdb_id: 2615211-3

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