In:
Frontiers in Immunology, Frontiers Media SA, Vol. 12 ( 2021-5-31)
Abstract:
The reason why most individuals with COVID-19 have relatively limited symptoms while other develop respiratory distress with life-threatening complications remains unknown. Increasing evidence suggests that COVID-19 associated adverse outcomes mainly rely on dysregulated immunity. Here, we compared transcriptomic profiles of blood cells from 103 patients with different severity levels of COVID-19 with that of 27 healthy and 22 influenza-infected individuals. Data provided a complete overview of SARS-CoV-2-induced immune signature, including a dramatic defect in IFN responses, a reduction of toxicity-related molecules in NK cells, an increased degranulation of neutrophils, a dysregulation of T cells, a dramatic increase in B cell function and immunoglobulin production, as well as an important over-expression of genes involved in metabolism and cell cycle in patients infected with SARS-CoV-2 compared to those infected with influenza viruses. These features also differed according to COVID-19 severity. Overall and specific gene expression patterns across groups can be visualized on an interactive website ( https://bix.unil.ch/covid/ ). Collectively, these transcriptomic host responses to SARS-CoV-2 infection are discussed in the context of current studies, thereby improving our understanding of COVID-19 pathogenesis and shaping the severity level of COVID-19.
Type of Medium:
Online Resource
ISSN:
1664-3224
DOI:
10.3389/fimmu.2021.666163
DOI:
10.3389/fimmu.2021.666163.s001
DOI:
10.3389/fimmu.2021.666163.s002
DOI:
10.3389/fimmu.2021.666163.s003
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10.3389/fimmu.2021.666163.s004
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10.3389/fimmu.2021.666163.s005
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10.3389/fimmu.2021.666163.s006
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10.3389/fimmu.2021.666163.s007
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10.3389/fimmu.2021.666163.s008
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10.3389/fimmu.2021.666163.s009
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10.3389/fimmu.2021.666163.s010
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10.3389/fimmu.2021.666163.s011
DOI:
10.3389/fimmu.2021.666163.s012
DOI:
10.3389/fimmu.2021.666163.s013
DOI:
10.3389/fimmu.2021.666163.s014
DOI:
10.3389/fimmu.2021.666163.s015
DOI:
10.3389/fimmu.2021.666163.s016
DOI:
10.3389/fimmu.2021.666163.s017
DOI:
10.3389/fimmu.2021.666163.s018
DOI:
10.3389/fimmu.2021.666163.s019
DOI:
10.3389/fimmu.2021.666163.s020
Language:
Unknown
Publisher:
Frontiers Media SA
Publication Date:
2021
detail.hit.zdb_id:
2606827-8
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