In:
Canadian Journal of Physiology and Pharmacology, Canadian Science Publishing, Vol. 78, No. 3 ( 2000-03-01), p. 237-243
Abstract:
Distribution of α 1 -adrenoceptor (α 1 AR) subtype (α 1A , α 1B , α 1D ) proteins in brain, heart, kidney, and liver of 1-week-old rats and in brain, heart, aorta, kidney, liver, vas deferens, prostate, and adrenal glands of adult rats was investigated by Western analysis, using receptor subtype specific polyclonal antibodies. High levels of immunoreactive α 1A AR and α 1D AR in brain and heart and of α 1B AR in liver and heart of neonatal rats were detected. In adult rat tissues, the abundance of α 1A AR protein was most marked in the brain, intermediate in heart, aorta, liver, vas deferens, and adrenals, and minimal in the kidney and prostate; relative to other tissues, the expression of α 1B AR was higher in brain and heart and that of α 1D AR in brain. All the three receptor subtypes increased with age in the brain cortex, whereas the abundance of α 1B AR increased in the heart but decreased in the liver; α 1A AR and α 1D AR in liver, kidney, and heart were not affected by age. It is concluded that α 1 AR subtypes are widely expressed in different neonatal and adult rat tissues.Key words: α 1A -adrenoceptors, α 1B -adrenoceptors, α 1D -adrenoceptors, α 1 -adrenoceptor proteins.
Type of Medium:
Online Resource
ISSN:
0008-4212
,
1205-7541
Language:
English
Publisher:
Canadian Science Publishing
Publication Date:
2000
detail.hit.zdb_id:
2004356-9
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