In:
Neurosurgical Review, Springer Science and Business Media LLC, Vol. 46, No. 1 ( 2023-08-18)
Abstract:
A benign peripheral nerve sheath tumor (bPNST) is a rare lesion associated with peripheral nerval structures. Symptoms may be heterogeneous, complicating diagnosis finding. Additionally, management concepts of bPNST may vary. In some cases, initial misdiagnosis leads to mistreatment resulting in severe functional deficits and chronic pain syndromes. Therefore, we analyzed patients treated for bPNST in our specialized institution with a primary focus on prior misdiagnosis and possible mistreatment. Patients with bPNSTs (schwannomas, neurofibromas, hybrid nerve sheath tumors, and perineuriomas) treated at the Neurosurgical Department between January 1, 2015, and July 31, 2021, were included. Assessment of demographics, tumor entity, tumor location, symptoms, the interval between the onset of symptoms and surgery, involved medical specialties, and outpatients’ treatment, with particular focus on initial misdiagnosis and inappropriate medical treatment, was performed. Eighty-five patients were included in the final analysis with schwannoma being the most prevalent histopathological diagnosis (schwannoma (75.3%, n =64), neurofibroma (12.9%, n =11), hybrid nerve sheath tumor (5.9%, n =5), and perineurioma (5.9%, n =5)). An incorrect primary diagnosis was detected in 44.7% ( n =38), leading to suboptimal or insufficient treatment in these cases. Of those, 28.9% ( n =11/38) were treated suboptimal, while 18.5% ( n =7/38) underwent unnecessary invasive diagnostics. Inappropriate surgery based on prior misdiagnosis, which led to severe neurological deficits in all these cases, was reported in 26.3% ( n =10/38). For the first time, our data shows the quantity and impact of incorrect initial diagnosis in bPNST causing a delay in causative treatment or resulting in unnecessary or potentially harmful treatment.
Type of Medium:
Online Resource
ISSN:
1437-2320
DOI:
10.1007/s10143-023-02107-z
Language:
English
Publisher:
Springer Science and Business Media LLC
Publication Date:
2023
detail.hit.zdb_id:
1474861-7
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