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  • 1
    In: Circulation, Ovid Technologies (Wolters Kluwer Health), Vol. 146, No. Suppl_1 ( 2022-11-08)
    Abstract: Background: Considering a paucity of pooled data on the influence of Body Mass Index (BMI) on long-term cardiac outcomes in individuals with Hypertrophic Obstructive Cardiomyopathy(HOCM), we conducted this systematic review. Methods: PUBMED, Scopus, EMBASE and Google Scholar were used to screen studies reporting Mortality/Major Adverse Cardiac Events (MACE) and Sudden Cardiac Death(SCD) among obese vs nonobese HOCM patients. Pooled odds ratios(OR) and heterogeneity were assessed with random-effects models and I 2 statistics. Subgroup analysis was performed to assess the risk by study type, sample size, country and procedure. The leave-one-study-out method was used for sensitivity analysis. Results: Of the 178 titles screened, we included 13 studies published between 2016-2022 with a total of 2,409,397 HOCM patients followed for a median of 6 years (1.8-8.2 year range). The sample had a higher proportion of males (61.33%) with a mean age of 56.3 years (37-78 year range). The unadjusted [OR=1.55(1.09-2.21), I 2 =96%] and adjusted [OR=1.28 (1.06-1.54), I 2 =82.7%] pooled odds of all-cause mortality were significantly higher with increased BMI. On subgroup analyses, prospective studies showed higher odds [n=3, 1.79 (1.23-2.6), p 〈 0.01] vs. retrospective ones [n=10, OR=1.2(0.99-1.46), p=0.06] . US Studies, which had large sample sizes, had higher odds [n 〉 =1000:OR=1.39(1.24-1.57)] but lower sample sizes from other countries [n 〈 1000] failed to show statistical significance. The odds of MACE increased with higher BMI [OR=4.27(3.50-5.21), p 〈 0.01], without a significant impact on the risk of SCD [p=0.10] . In those who underwent septal myectomy, increased BMI was associated with higher post-procedural all-cause mortality [OR=1.12(1.02-1.22), p=0.01]. Conclusions: A higher BMI/obesity in HOCM is associated with increased all-cause mortality, MACE and mortality after septal myectomy on a long-term follow-up ( 〉 5 years), without an association with SCD risk.
    Type of Medium: Online Resource
    ISSN: 0009-7322 , 1524-4539
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2022
    detail.hit.zdb_id: 1466401-X
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  • 2
    Online Resource
    Online Resource
    American Society of Clinical Oncology (ASCO) ; 2020
    In:  Journal of Clinical Oncology Vol. 38, No. 29_suppl ( 2020-10-10), p. 97-97
    In: Journal of Clinical Oncology, American Society of Clinical Oncology (ASCO), Vol. 38, No. 29_suppl ( 2020-10-10), p. 97-97
    Abstract: 97 Background: Cancer-related mortality has been found to be disproportionately higher in racial minorities and medically underserved populations.[1] This necessitates adequate representation of these subgroups in clinical trials for these practices to become an acceptable benchmark for all.However, this has been historically challenging and various studies have failed to show the equitable representation of various ethnic groups in these trials that ultimately guide clinical practice. Methods: We reviewed all abstracts presented at the 2020 ASCO Virtual meeting, from which we selected abstracts discussing results from phase III trials. Of these, we included phase III studies that provided explicit information on the demographic distribution of the clinical trial participants with respect to their race/ethnicity. We then extracted information on the demographic data of participants in the clinical trial using the slides or posters available on the ASCO website. Further, we utilized descriptive statistics to analyze and compare the clinical trial population with the general cancer population using the 2020 ACS Cancer statistics. However, our analysis was potentially limited by the absence of full demographic distribution when previously described elsewhere and the lack of uniform reporting of different ethnicities among these abstracts. Results: Of the total 476 abstracts studied, 120 described phase III studies. Among these, 23 did provide detailed demographic (race/ethnicity) distribution. However, 98 studies did not include standardized subgroups (White, African American, and Others) and 6 studies provided data only on Whites. A total of 9 studies were included in the final analysis. Overall, the following was found: White 7083 (76.8%), African Americans 675 (7.3%), and “Others” 1466 (15.9%). Meanwhile, a comparison of cancer demographic data from the American Cancer Society (ACS) demonstrates the overall cancer incidence rates from 2012-2017 was found to be 464.6/100,000 in non-Hispanic whites and a comparable 460/100,000 in Non-Hispanic Blacks. However, our analysis shows that these ethnic minorities continue to be severely underrepresented in these phase III clinical trials. Conclusions: Despite several efforts, health care disparities persist and racial minorities continue to be underrepresented in cancer clinical trials. Further measures are needed to ensure adequate representation, healthcare equity and the generalizable nature of these “practice-changing” trials. References: 1. https://seer.cancer.gov/csr/1975_2017/results_merged/topic_race_ethnicity.pdf .
    Type of Medium: Online Resource
    ISSN: 0732-183X , 1527-7755
    RVK:
    RVK:
    Language: English
    Publisher: American Society of Clinical Oncology (ASCO)
    Publication Date: 2020
    detail.hit.zdb_id: 2005181-5
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  • 3
    Online Resource
    Online Resource
    Oxford University Press (OUP) ; 2022
    In:  Postgraduate Medical Journal Vol. 98, No. 1165 ( 2022-11-01), p. 830-836
    In: Postgraduate Medical Journal, Oxford University Press (OUP), Vol. 98, No. 1165 ( 2022-11-01), p. 830-836
    Abstract: Hospital quality improvement and hospital performance are commonly evaluated using parameters such as average length of stay (LOS), patient safety measures and rates of hospital readmission. Thirty-day readmission (30-DR) rates are widely used as a quality indicator and a quantifiable metric for hospitals since patients are often readmitted for the exacerbation of conditions from index admission. The quality of patient education and postdischarge care can influence readmission rates. We report the 30-DR rates of patients with asthma using a national dataset for the year 2013. Objectives The aim of our study was to assess the 30- day readmission (30-DR) rate as well as, the causes and predictors of readmissions. Study designs/methods Using the Nationwide Readmission Database (NRD) (2013), we identified primary discharge diagnoses of asthma by using International Classification of Diseases, Ninth Revision, Clinical Modification code ‘493’. Categorical and continuous variables were assessed by a χ2 test and a Student's t-test, respectively. The independent predictors of unplanned 30-DR were detected by multivariate analysis. We used sampling weights, which are provided in the NRD, to generate the national estimates. Results There were 130 490 (weighted N=311 173) inpatient asthma admissions during 2013. The overall 30-DR for asthma was 11.9%. The associated factors for 30-DR were age 45–84 years (40.32% vs 29.05%; p & lt;0.001), enrolment in Medicare (49.33% vs 30.61% p & lt;0.001), extended LOS (mean, 4.40±0.06 vs 3.25±0.04 days; p & lt;0.001), higher mean cost (US$8593.91 vs US$6741.31; p & lt;0.001) and higher disposition against medical advice (DAMA) (4.14% vs 1.51%; p & lt;0.001). The factors that increased the chance of 30-DR were advanced age (≥45–64 vs ≤17 years; OR 4.61, 95% CI 4.04 to 5.27, p & lt;0.0001), male sex (OR 1.19, 95% CI 1.13 to 1.26, p & lt;0.0001), a higher Charlson Comorbidity Index (CCI) (OR 1.16, 95% CI 1.14 to 1.18, p & lt;0.0001), DAMA (OR 2.32, 95% CI 2.08 to 2.59, p & lt;0.0001), non-compliance with medication (OR 1.34, 95% CI 1.24 to 1.46, p & lt;0.0001), post-traumatic stress disorder (OR 1.48, 95% CI 1.22 to 1.79, p & lt;0.0001), alcohol use (OR 1.45, 95% CI 1.27 to 1.65, p & lt;0.0001), gastro-oesophageal reflux disease (OR 1.20, 95% CI 1.14 to 1.27, p & lt;0.0001), obstructive sleep apnoea (OR 1.11, 95% CI 1.03 to 1.18, p & lt;0.0042) and hypertension (OR 1.11, 95% CI 1.06 to 1.17, p & lt;0.0001). Conclusions We found that the overall 30-DR rate for asthma was 11.9% all-cause readmission. Major causes of 30-DR were asthma exacerbation (36.74%), chronic obstructive pulmonary disease (11.47%), respiratory failure (6.46%), non-specific pneumonia (6.19%), septicaemia (3.61%) and congestive heart failure (3.32%). One-fourth of the revisits occurred in the first week, while half of the revisits took place in the first 2 weeks. Education regarding illness and the importance of medicine compliance could play a significant role in preventing asthma-related readmission.
    Type of Medium: Online Resource
    ISSN: 0032-5473 , 1469-0756
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2022
    detail.hit.zdb_id: 2009568-5
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  • 4
    In: Acta Paediatrica, Wiley, Vol. 107, No. S471 ( 2018-12), p. 72-79
    Abstract: To evaluate the effectiveness of an mH ealth intervention in improving knowledge and skills of accredited social health activists in improving maternal, newborn and child health care in India. Methods This was a nested cross‐sectional study within a cluster randomised controlled trial. The intervention was a mobile phone application which has inbuilt health education videos, algorithms to diagnose complications and training tools to educate accredited social health activists. A total of 124 were randomly selected from the control (n = 61) and intervention (n = 63) arms of the larger study after six months of training in Bharuch and Narmada districts of Gujarat. Results The knowledge of accredited social health activists regarding pregnancy ( OR : 2.51, CI : 1.12–5.64) and newborn complications ( OR : 2.57, CI : 1.12–5.92) was significantly higher in the intervention arm compared to the control arm. The knowledge of complications during delivery ( OR : 1.36, CI : 0.62–2.98) and the postpartum ( OR : 1.06, CI : 0.48–2.33) period was similar in both groups. The activists from the intervention arm demonstrated better skills for measuring temperature ( OR : 4.25, CI : 1.66–10.89) of newborns compared to the control group. Conclusion The results suggest potential benefits of this mH ealth intervention for improving knowledge and skills of accredited social health activists.
    Type of Medium: Online Resource
    ISSN: 0803-5253 , 1651-2227
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 1492629-5
    detail.hit.zdb_id: 1501466-6
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  • 5
    Online Resource
    Online Resource
    American Society of Clinical Oncology (ASCO) ; 2019
    In:  Journal of Clinical Oncology Vol. 37, No. 15_suppl ( 2019-05-20), p. e18246-e18246
    In: Journal of Clinical Oncology, American Society of Clinical Oncology (ASCO), Vol. 37, No. 15_suppl ( 2019-05-20), p. e18246-e18246
    Abstract: e18246 Background: Testicular tumors are potentially curable by means of high-dose chemotherapy plus hematopoietic stem-cell rescue. This regimen is commonly used as salvage therapy, third-line or later therapy in patients with platinum-refractory disease. The utilization and real-world outcomes and complications of patients with testicular cancer undergoing autologous hematopoietic stem cell transplant (aHSCT) in United States are unknown. Methods: We queried National Inpatient Sample, a large inpatient data set in the United States, from 2005 to 2014 for male patients with testicular cancer or multiple myeloma (control group) receiving aHSCT and compared outcomes between these groups. The primary outcome was in-hospital mortality rate, and the secondary outcomes included in-hospital complications of aHSCT, length of stay and total charges. Outcomes were assessed by means of univariate analysis, multivariate regression and propensity score matched-pair analysis. Results: A total of 391 patients (weighted N = 1,909) with testicular cancer and 4,809 male patients (weighted N = 23,501) with multiple myeloma who underwent aHSCT from 2005 to 2014 were identified. Mean age of patients with testicular cancer was 32.3 years vs 59 years for multiple myeloma patients (p 〈 0.001) There were no differences in in-hospital mortality rates (1.5% vs 1.4%, p = 0.85) or rates of intubation (2.3% vs 1.6%, p = 0.36), sepsis (7.7% vs 7.5%, p = 0.94), bacteremia (13.5% vs 15.6%, p = 0.42), or stomatitis (43.8% vs 38.8%, p = 0.87) between patients with testicular cancer and multiple myeloma receiving autologous HSCT. However, utilization of total parenteral nutrition was higher in patients with testicular cancer (12.9% vs 4.7%, p 〈 0.001). There was no difference in length of stay (17.5 vs 17.5 days, p = 0.77) and total charges (121,120$ vs 123,729$, p = 0.74) between two groups. The results were consistent in multivariate and propensity score matched-pair analysis. Conclusions: The in-hospital outcomes of patients with testicular cancer receiving aHSCT appears to be similar to patients with multiple myeloma. However, overall utilization of aHSCT for testicular cancer appears to be low in United States.
    Type of Medium: Online Resource
    ISSN: 0732-183X , 1527-7755
    RVK:
    RVK:
    Language: English
    Publisher: American Society of Clinical Oncology (ASCO)
    Publication Date: 2019
    detail.hit.zdb_id: 2005181-5
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  • 6
    In: Circulation, Ovid Technologies (Wolters Kluwer Health), Vol. 146, No. Suppl_1 ( 2022-11-08)
    Abstract: Background: There is a scarcity of large-scale data on race, sex, and economic status-based disparities in trends of subsequent/recurrent myocardial infarction (MI) in elderly individuals who have had a previous MI. Methods: National Inpatient Sample databases (2016-2019, ICD10 codes) were queried to identify elderly (≥65 years) patients with prior MI and divided into having and not having subsequent MI admissions. Primary outcomes were nationwide trends in subsequent MI admissions and all-cause in-hospital mortality in these patients with racial, sex, and economic status disparities. Results: A total of 421,960 recurrent MI admissions were identified [61.1% male, 38.9% female, 80.7% white and median age 76yrs (p 〈 0.001)]. Between 2016 and 2019, both males and females experienced an increase in recurrent MI from 9.1 to 10.6% and 8.1 to 9.8%, respectively, but a reassuring decrease in in-hospital mortality from 7.75 to 6.4% and 7.8 to 6.6% (P trends 〈 0.001). All race groups demonstrated a rise in recurrent MI, with blacks experiencing the largest increase from 9.2 to 11.7%(P trend 〈 0.001). In-hospital mortality for recurrent MI declined in all races except blacks and Native Americans (P trends 〉 0.05), with Asian/Pacific Islanders experiencing the highest decline from 13 to 7.4%(P trends 〈 0.001). All income quartile groups had an increase in recurrent MI with a more prominent increase in the lowermost income quartile cohort (P trends 〈 0.001). There was an overall trend of decreasing in-hospital mortality except for the lowermost income quartile which did not show improving trends in mortality (P trend =0.079). Conclusions: Elderly patients with a history of MI had an upward tendency for recurrent MI hospitalizations but a downward trend for all-cause in-hospital mortality with prevailing racial and socioeconomic disparities. Blacks and lower income quartile patients with CVD risk may need focused post-MI care to curtail subsequent MI and mortality risk.
    Type of Medium: Online Resource
    ISSN: 0009-7322 , 1524-4539
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2022
    detail.hit.zdb_id: 1466401-X
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  • 7
    In: International Journal of Cardiology, Elsevier BV, Vol. 309 ( 2020-06), p. 14-18
    Type of Medium: Online Resource
    ISSN: 0167-5273
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2020
    detail.hit.zdb_id: 1500478-8
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  • 8
    In: International Journal of Cardiology, Elsevier BV, Vol. 316 ( 2020-10), p. 43-46
    Type of Medium: Online Resource
    ISSN: 0167-5273
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2020
    detail.hit.zdb_id: 1500478-8
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  • 9
    In: Circulation, Ovid Technologies (Wolters Kluwer Health), Vol. 146, No. Suppl_1 ( 2022-11-08)
    Abstract: Background: Contemporary literature lacks data on the impact of climatic variations on the etiopathogenesis and outcomes of Takotsubo Syndrome (TTS)-related hospitalization in the U.S. Methods: Seasonal variation was identified based on meteorological classification of the northern hemisphere Spring, Summer, Fall and Winter using data from the National Inpatient Sample (2019) and odds of outcomes were assessed using multivariable regression models. Results: The TTS cohort (n=41830) in 2019 was mostly caucasian (80.6%), female (82.1%), and median age ≥65yrs (61.9%). Fall (25.9%) admissions were the highest, followed by summer (25%), spring (24.6%) and winter (24.5%). Despite a similar median length of stay (4-days; p 〈 0.001), winter hospitalization expenditures (USD56763) were the highest and fall lowest (USD51649). Winter admissions had greater all-cause mortality (7.3%vs.6.7%) and dysrhythmias (29.8%vs.28.5%), including Atrial fibrillation (AF) (20.7%vs. 19.7%). Admissions in spring had a higher cardiac arrest (4.8%vs.4.1%) and Acute Venous Thromboembolism (VTE) (4.7%vs.3.5%) compared to overall TTS-related admissions. When adjusted for confounders, a higher risk of dysrhythmias was noted for [winter (OR:1.20; 95%CI:1.03-1.39), Spring (OR:1.15;95%CI:1.00-1.33) and Fall (OR:1.18;95%CI:1.03-1.36) vs. summer; p=0.063]. A higher risk was also noted for AF in winter (OR:1.22;95%CI:1.02-1.45), Spring (OR:1.20;95%CI:1.02-1.42) and Fall (OR:1.28;95%CI:1.08-1.51) when compared to summer; p=0.028] . Spring admissions had a greater risk of VTE than summer admissions [(OR:1.54;95%CI:1.09-2.16) vs. summer; p=0.067]. Other outcomes, such as all-cause mortality and cardiogenic shock, had an association after controlling for confounding variables. Conclusions: Compared to Summer, Winter hospitalizations increased the risk of dysrhythmia and AF, while Spring admissions revealed a higher risk of VTE.
    Type of Medium: Online Resource
    ISSN: 0009-7322 , 1524-4539
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2022
    detail.hit.zdb_id: 1466401-X
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  • 10
    Online Resource
    Online Resource
    American Society of Clinical Oncology (ASCO) ; 2020
    In:  JCO Global Oncology , No. 6 ( 2020-11), p. 557-559
    In: JCO Global Oncology, American Society of Clinical Oncology (ASCO), , No. 6 ( 2020-11), p. 557-559
    Type of Medium: Online Resource
    ISSN: 2687-8941
    Language: English
    Publisher: American Society of Clinical Oncology (ASCO)
    Publication Date: 2020
    detail.hit.zdb_id: 3018917-2
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