In:
FEBS Open Bio, Wiley, Vol. 5, No. 1 ( 2015-01), p. 8-19
Abstract:
Multicellular spheroids (MCS) express low levels of Par‐4 and are resistant to TAM‐induced cytotoxicity. Par‐4 is secreted in TAM‐treated monolayers but not MCS and is crucial for cell death. Secretory Par‐4 (from TAM‐treated cells) renders MCS sensitive to cell death. Inhibitors to AKT/PKCζ sensitized MCS to TAM‐induced cytotoxicity. A combination of TAM with PI3K inhibitor resulted in secretory Par‐4.
Type of Medium:
Online Resource
ISSN:
2211-5463
,
2211-5463
DOI:
10.1016/j.fob.2014.11.005
Language:
English
Publisher:
Wiley
Publication Date:
2015
detail.hit.zdb_id:
2651702-4
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