In:
Acta Endocrinologica, Oxford University Press (OUP), Vol. 64, No. 4 ( 1970-08), p. 705-717
Abstract:
The influence of large doses of F-6103 (bis-/p-acetoxyphenyl/-2-methylcyclohexylidene methane) on implantation and early gestation was studied in clinical experiments. In the first study, 600 mg of F-6103 were administered daily for 2 to 6 days beginning from 43 to 72 days after the first day of the last menstrual period. Spontaneous abortion, or foetal death occurred in 6 out of 26 women, as compared to 3 out of 24 untreated cases. The difference is statistically not significant. In the second study 10 women exhibiting a positive pregnancy diagnosis test were treated with 600 mg of F-6103 daily for 7 days beginning from 32 to 48 days after the first day of the last menstrual period. Repeated immunological pregnancy tests were positive in all of them until curettage was performed 18 to 38 days following discontinuation of the treatment. Histopathological examination revealed in all subjects, but one, the presence of normally developed chorionic tissue exhibiting no signs of degenerations. In three cases well preserved foetal tissues were also found. In the third study 16 women with proven fertility were treated from the 14th day of the cycle daily for 7 days with 600 mg of F-6103. Pregnancy occurred in 4 women after 1 to 6 courses of treatment. The data indicate that in the dose schedule employed F-6103 has neither abortifacient nor postovulatory contraceptive effect in women.
Type of Medium:
Online Resource
ISSN:
0804-4643
,
1479-683X
DOI:
10.1530/acta.0.0640705
Language:
Unknown
Publisher:
Oxford University Press (OUP)
Publication Date:
1970
detail.hit.zdb_id:
1485160-X
Bookmarklink