In:
cclm, Walter de Gruyter GmbH, Vol. 37, No. 7 ( 1999-07-01), p. 719-721
Abstract:
A heterozygous polymorphism changing GGT 40 (Gly) to AGT 40 (Ser) in the glucagon receptor gene (GCG-R) was reported to be associated with non-insulin-dependent diabetes mellitus (NIDDM). A possible involvement of this polymorphism in impaired glucose tolerance was also suggested in a French population. However, the prevalence of this polymorphism differs markedly among different ethnic groups, whereby the results in German populations were found to be contradictory. We thus investigated the association of this mutation with NIDDM and healthy subjects in 508 German subjects (196 NIDDM, and 312 controls). None of the control subjects, but one of the NIDDM patients demonstrated the Gly40Ser polymorphism. Since no first-degree relative of the index patient had this genetic variance, a de novo mutation is suggested. Although the frequency of the Gly40Ser polymorphism in NIDDM observed in France is not confirmed in our population, this genetic variance is also evident in Germany.
Type of Medium:
Online Resource
ISSN:
1434-6621
DOI:
10.1515/CCLM.1999.110
Language:
English
Publisher:
Walter de Gruyter GmbH
Publication Date:
1999
detail.hit.zdb_id:
1492732-9
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