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Figure 9 from: Förstner KU, Becker A, Blom J, Bork P, Clavel T, Dieckmann M, Goesmann A, Götz B, Gübitz T, Hufsky F, Jünemann S, Körner M-L, Marz M, Da Rocha UN, Overmann J, Pühler A, Rebholz-Schuhmann D, Sczyrba A, Stoye J, Vandendorpe J, Van Rossum T, McHardy A (2023) NFDI4Microbiota – national research data infrastructure for microbiota research. Research Ideas and Outcomes 9: e110501. https://doi.org/10.3897/rio.9.e110501

Förstner, Konrad U. ; Becker, Anke ; Blom, Jochen ; [et al.]

Pensoft Publishers ; 2023

In: Research Ideas and Outcomes Vol. 9 ( 2023-08-24)

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In: Research Ideas and Outcomes, Pensoft Publishers, Vol. 9 ( 2023-08-24)

Abstract: Microbes – bacteria, archaea, unicellular eukaryotes, and viruses – play an important role in human and environmental health. Growing awareness of this fact has led to a huge increase in microbiological research and applications in a variety of fields. Driven by technological advances that allow high-throughput molecular characterization of microbial species and communities, microbiological research now offers unparalleled opportunities to address current and emerging needs. As well as helping to address global health threats such as antimicrobial resistance and viral pandemics, it also has a key role to play in areas such as agriculture, waste management, water treatment, ecosystems remediation, and the diagnosis, treatment and prevention of various diseases. Reflecting this broad potential, billions of euros have been invested in microbiota research programs worldwide. Though run independently, many of these projects are closely related. However, Germany currently has no infrastructure to connect such projects or even compare their results. Thus, the potential synergy of data and expertise is being squandered. The goal of the NFDI4Microbiota consortium is to serve and connect this broad and heterogeneous research community by elevating the availability and quality of research results through dedicated training, and by facilitating the generation, management, interpretation, sharing, and reuse of microbial data. In doing so, we will also foster interdisciplinary interactions between researchers. NFDI4Microbiota will achieve this by creating a German microbial research network through training and community-building activities, and by creating a cloud-based system that will make the storage, integration and analysis of microbial data, especially omics data, consistent, reproducible, and accessible across all areas of life sciences. In addition to increasing the quality of microbial research in Germany, our training program will support widespread and proper usage of these services. Through this dual emphasis on education and services, NFDI4Microbiota will ensure that microbial research in Germany is synergistic and efficient, and thus excellent. By creating a central resource for German microbial research, NDFDI4Microbiota will establish a connecting hub for all NFDI consortia that work with microbiological data, including GHGA, NFDI4Biodiversity, NFDI4Agri and several others. NFDI4Microbiota will provide non-microbial specialists from these consortia with direct and easy access to the necessary expertise and infrastructure in microbial research in order to facilitate their daily work and enhance their research. The links forged through NFDI4Microbiota will not only increase the synergy between NFDI consortia, but also elevate the overall quality and relevance of microbial research in Germany.

Type of Medium: Online Resource

ISSN: 2367-7163

URL: Article

DOI: 10.3897/rio.9.e110501

DOI: 10.3897/rio.9.e110501.figure1

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DOI: 10.3897/rio.9.e110501.figure4a

DOI: 10.3897/rio.9.e110501.figure4b

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DOI: 10.3897/rio.9.e110501.figure9

Language: Unknown

Publisher: Pensoft Publishers

Publication Date: 2023

detail.hit.zdb_id: 2833254-4

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Supplementary material 6 from: Lötters S, Mebs D, Köhler G, Vargas J, La Marca E (2019) The voice from the hereafter: vocalisations in three species of Atelopus from the Venezuelan Andes, likely to be extinct. Herpetozoa 32: 267-275. https://doi.org/10.3897/herpetozoa.32.e39192

Lötters, Stefan ; Mebs, Dietrich ; Köhler, Gunther ; [et al.]

Pensoft Publishers ; 2019

In: Herpetozoa Vol. 32 ( 2019-12-04), p. 267-275

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In: Herpetozoa, Pensoft Publishers, Vol. 32 ( 2019-12-04), p. 267-275

Abstract: Atelopus is a species-rich group of Neotropical bufonids. Present knowledge on bioacoustics in this genus is relatively poor, as vocalisations have been described in only about one fifth of the ca. 100 species known. All studied members of the genus produce vocalisations although, with a few exceptions, most species lack a middle ear. Nonetheless, hearing has been demonstrated even in earless Atelopus making bioacoustics in these toads an inspiring research field. So far, three structural call types have been identified in the genus. As sympatry is uncommon in Atelopus , calls of the same type often vary little between species. Based on recordings from the 1980s, we describe vocalisations of three Venezuelan species ( A. carbonerensis , A. mucubajiensis , A. tamaense ) from the Cordillera de Mérida, commonly known as the Andes of Venezuela and the Tamá Massif, a Venezuelan spur of the Colombian Cordillera Oriental. Vocalisations correspond, in part, to the previously identified call types in Atelopus . Evaluation of the vocalisations of the three species presented in this study leads us to recognise a fourth structural call type for the genus. With this new addition, the Atelopus acoustic repertoire now includes (1) pulsed calls, (2) pure tone calls, (3) pulsed short calls and (4) pure tone short calls. The call descriptions provided here are valuable contributions to the bioacoustics of these Venezuelan Atelopus species, since all of them have experienced dramatic population declines that limit possibilities of further studies.

Type of Medium: Online Resource

ISSN: 2682-955X , 1013-4425

URL: Article

DOI: 10.3897/herpetozoa.32.e39192

DOI: 10.3897/herpetozoa.32.e39192.figure1

DOI: 10.3897/herpetozoa.32.e39192.figure2

DOI: 10.3897/herpetozoa.32.e39192.figure3

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DOI: 10.3897/herpetozoa.32.e39192.figure7

DOI: 10.3897/herpetozoa.32.e39192.figure8

DOI: 10.3897/herpetozoa.32.e39192.suppl1

DOI: 10.3897/herpetozoa.32.e39192.suppl2

DOI: 10.3897/herpetozoa.32.e39192.suppl3

DOI: 10.3897/herpetozoa.32.e39192.suppl4

DOI: 10.3897/herpetozoa.32.e39192.suppl5

DOI: 10.3897/herpetozoa.32.e39192.suppl6

Language: Unknown

Publisher: Pensoft Publishers

Publication Date: 2019

detail.hit.zdb_id: 2474932-1

SSG: 12

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Figure 9 from: Jiang J, Dietrich CH, Li C, Song Y (2022) Comparative morphology of part of the integumental fine structure of two Erythroneurine species: Singapora shinshana (Matsumura, 1932) and Empoascanara sipra Dworakowska, 1980 (Hemiptera, Cicadellidae, Typhlocybinae). ZooKeys 1103: 1-23. https://doi.org/10.3897/zookeys.1103.80787

Jiang, Jia ; Dietrich, Christopher H. ; Li, Can ; [et al.]

Pensoft Publishers ; 2022

In: ZooKeys Vol. 1103 ( 2022-05-26), p. 1-23

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In: ZooKeys, Pensoft Publishers, Vol. 1103 ( 2022-05-26), p. 1-23

Abstract: This study describes the fine structure of the mouthparts, antennae, forewings, and brochosomes of two leafhopper species belonging to the typhlocybine tribe Erythroneurini collected from the Karst area of Guizhou Province, southern China: Singapora shinshana , which prefers woody dicot hosts, and Empoascanara sipra , which feeds on grasses. As in other leafhoppers, the piercing-sucking mouthparts consist of a conical labrum, a cylindrical three-segmented labium, and a slender stylet fascicle. The labrum of both species has no sensilla and the labium has several common types of sensilla, but the two species differ in the numbers, types, and distribution of sensilla and in other aspects of the surface sculpture of the mouthparts. The stylet fascicle has distinctive dentition on both the maxillary and mandibular stylets. The antennae of the two species differ in several respects, including the sensilla and sculpture of the scape, pedicel, and flagellum, as well as the degree of sub-segmentation of the flagellum. Except for the variable scaly structure and rounded protrusions on the surface of S. shinshana , the fine structure of the forewing surfaces of the two species are similar to those of other leafhoppers. Only small spherical brochosomes were found on the body surface of S. shinshana and E. sipra . Similar studies of additional erythroneurine species are needed to determine whether differences in mouthpart and antennal fine structure may reflect adaptation to different host plant.

Type of Medium: Online Resource

ISSN: 1313-2970 , 1313-2989

URL: Article

DOI: 10.3897/zookeys.1103.80787

DOI: 10.3897/zookeys.1103.80787.figure1

DOI: 10.3897/zookeys.1103.80787.figure2

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DOI: 10.3897/zookeys.1103.80787.figure8

DOI: 10.3897/zookeys.1103.80787.figure9

Language: Unknown

Publisher: Pensoft Publishers

Publication Date: 2022

detail.hit.zdb_id: 2445640-8

SSG: 12

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Session IV: Posters

Al‐Dabbagh, W.Y. ; Allan, M.C. ; Arendt, E.K. ; [et al.]

Informa UK Limited ; 1990

In: Food Biotechnology Vol. 4, No. 1 ( 1990-01), p. 471-490

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In: Food Biotechnology, Informa UK Limited, Vol. 4, No. 1 ( 1990-01), p. 471-490

Type of Medium: Online Resource

ISSN: 0890-5436 , 1532-4249

URL: Article

DOI: 10.1080/08905439009549759

Language: English

Publisher: Informa UK Limited

Publication Date: 1990

detail.hit.zdb_id: 2092966-3

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Figure 4 from: Borsch T, Stevens A-D, Häffner E, Güntsch A, Berendsohn WG, Appelhans MS, Barilaro C, Beszteri B, Blattner FR, Bossdorf O, Dalitz H, Dressler S, Duque-Thüs R, Esser H-J, Franzke A, Goetze D, Grein M, Grünert U, Hellwig F, Hentschel J, Hörandl E, Janßen T, Jürgens N, Kadereit G, Karisch T, Koch MA, Müller F, Müller J, Ober D, Porembski S, Poschlod P, Printzen C, Röser M, Sack P, Schlüter P, Schmidt M, Schnittler M, Scholler M, Schultz M, Seeber E, Simmel J, Stiller M, Thiv M, Thüs H, Tkach N, Triebel D, Warnke U, Weibulat T, Wesche K, Yurkov A, Zizka G (2020) A complete digitization of German herbaria is possible, sensible and should be started now. Research Ideas and Outcomes 6: e50675. https://doi.org/10.3897/rio.6.e50675

Borsch, Thomas ; Stevens, Albert-Dieter ; Häffner, Eva ; [et al.]

Pensoft Publishers ; 2020

In: Research Ideas and Outcomes Vol. 6 ( 2020-02-03)

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In: Research Ideas and Outcomes, Pensoft Publishers, Vol. 6 ( 2020-02-03)

Abstract: Plants, fungi and algae are important components of global biodiversity and are fundamental to all ecosystems. They are the basis for human well-being, providing food, materials and medicines. Specimens of all three groups of organisms are accommodated in herbaria, where they are commonly referred to as botanical specimens. The large number of specimens in herbaria provides an ample, permanent and continuously improving knowledge base on these organisms and an indispensable source for the analysis of the distribution of species in space and time critical for current and future research relating to global biodiversity. In order to make full use of this resource, a research infrastructure has to be built that grants comprehensive and free access to the information in herbaria and botanical collections in general. This can be achieved through digitization of the botanical objects and associated data. The botanical research community can count on a long-standing tradition of collaboration among institutions and individuals. It agreed on data standards and standard services even before the advent of computerization and information networking, an example being the Index Herbariorum as a global registry of herbaria helping towards the unique identification of specimens cited in the literature. In the spirit of this collaborative history, 51 representatives from 30 institutions advocate to start the digitization of botanical collections with the overall wall-to-wall digitization of the flat objects stored in German herbaria. Germany has 70 herbaria holding almost 23 million specimens according to a national survey carried out in 2019. 87% of these specimens are not yet digitized. Experiences from other countries like France, the Netherlands, Finland, the US and Australia show that herbaria can be comprehensively and cost-efficiently digitized in a relatively short time due to established workflows and protocols for the high-throughput digitization of flat objects. Most of the herbaria are part of a university (34), fewer belong to municipal museums (10) or state museums (8), six herbaria belong to institutions also supported by federal funds such as Leibniz institutes, and four belong to non-governmental organizations. A common data infrastructure must therefore integrate different kinds of institutions. Making full use of the data gained by digitization requires the set-up of a digital infrastructure for storage, archiving, content indexing and networking as well as standardized access for the scientific use of digital objects. A standards-based portfolio of technical components has already been developed and successfully tested by the Biodiversity Informatics Community over the last two decades, comprising among others access protocols, collection databases, portals, tools for semantic enrichment and annotation, international networking, storage and archiving in accordance with international standards. This was achieved through the funding by national and international programs and initiatives, which also paved the road for the German contribution to the Global Biodiversity Information Facility (GBIF). Herbaria constitute a large part of the German botanical collections that also comprise living collections in botanical gardens and seed banks, DNA- and tissue samples, specimens preserved in fluids or on microscope slides and more. Once the herbaria are digitized, these resources can be integrated, adding to the value of the overall research infrastructure. The community has agreed on tasks that are shared between the herbaria, as the German GBIF model already successfully demonstrates. We have compiled nine scientific use cases of immediate societal relevance for an integrated infrastructure of botanical collections. They address accelerated biodiversity discovery and research, biomonitoring and conservation planning, biodiversity modelling, the generation of trait information, automated image recognition by artificial intelligence, automated pathogen detection, contextualization by interlinking objects, enabling provenance research, as well as education, outreach and citizen science. We propose to start this initiative now in order to valorize German botanical collections as a vital part of a worldwide biodiversity data pool.

Type of Medium: Online Resource

ISSN: 2367-7163

URL: Article

DOI: 10.3897/rio.6.e50675

DOI: 10.3897/rio.6.e50675.r166357

DOI: 10.3897/rio.6.e50675.r166356

DOI: 10.3897/rio.6.e50675.figure1

DOI: 10.3897/rio.6.e50675.figure2

DOI: 10.3897/rio.6.e50675.figure3

DOI: 10.3897/rio.6.e50675.figure4

Language: Unknown

Publisher: Pensoft Publishers

Publication Date: 2020

detail.hit.zdb_id: 2833254-4

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Asthmatherapie bei Kindern und Erwachsenen : Empfehlungen der Deutschen Atemwegsliga in der Deutschen Gesellschaft für Pneumologie

Wettengel, Ralf ; Berdel, Dietrich ; Hofmann, Dietrich ; [et al.]

Springer Science and Business Media LLC ; 1998

In: Medizinische Klinik Vol. 93, No. 11 ( 1998-11), p. 639-650

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In: Medizinische Klinik, Springer Science and Business Media LLC, Vol. 93, No. 11 ( 1998-11), p. 639-650

Type of Medium: Online Resource

ISSN: 0723-5003 , 1615-6722

URL: Article

DOI: 10.1007/BF03044875

RVK:

XA 10000

Language: German

Publisher: Springer Science and Business Media LLC

Publication Date: 1998

detail.hit.zdb_id: 2233632-1

detail.hit.zdb_id: 2636049-4

detail.hit.zdb_id: 2017822-0

SSG: 7,52

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Synaptic processes and immune-related pathways implicated in Tourette syndrome

Tsetsos, Fotis ; Yu, Dongmei ; Sul, Jae Hoon ; [et al.]

Springer Science and Business Media LLC ; 2021

In: Translational Psychiatry Vol. 11, No. 1 ( 2021-01-18)

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In: Translational Psychiatry, Springer Science and Business Media LLC, Vol. 11, No. 1 ( 2021-01-18)

Abstract: Tourette syndrome (TS) is a neuropsychiatric disorder of complex genetic architecture involving multiple interacting genes. Here, we sought to elucidate the pathways that underlie the neurobiology of the disorder through genome-wide analysis. We analyzed genome-wide genotypic data of 3581 individuals with TS and 7682 ancestry-matched controls and investigated associations of TS with sets of genes that are expressed in particular cell types and operate in specific neuronal and glial functions. We employed a self-contained, set-based association method (SBA) as well as a competitive gene set method (MAGMA) using individual-level genotype data to perform a comprehensive investigation of the biological background of TS. Our SBA analysis identified three significant gene sets after Bonferroni correction, implicating ligand-gated ion channel signaling, lymphocytic, and cell adhesion and transsynaptic signaling processes. MAGMA analysis further supported the involvement of the cell adhesion and trans-synaptic signaling gene set. The lymphocytic gene set was driven by variants in FLT3 , raising an intriguing hypothesis for the involvement of a neuroinflammatory element in TS pathogenesis. The indications of involvement of ligand-gated ion channel signaling reinforce the role of GABA in TS, while the association of cell adhesion and trans-synaptic signaling gene set provides additional support for the role of adhesion molecules in neuropsychiatric disorders. This study reinforces previous findings but also provides new insights into the neurobiology of TS.

Type of Medium: Online Resource

ISSN: 2158-3188

URL: Article

DOI: 10.1038/s41398-020-01082-z

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2021

detail.hit.zdb_id: 2609311-X

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Polygenic risk score-based phenome-wide association study identifies novel associations for Tourette syndrome

Jain, Pritesh ; Miller-Fleming, Tyne ; Topaloudi, Apostolia ; [et al.]

Springer Science and Business Media LLC ; 2023

In: Translational Psychiatry Vol. 13, No. 1 ( 2023-02-23)

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In: Translational Psychiatry, Springer Science and Business Media LLC, Vol. 13, No. 1 ( 2023-02-23)

Abstract: Tourette Syndrome (TS) is a complex neurodevelopmental disorder characterized by vocal and motor tics lasting more than a year. It is highly polygenic in nature with both rare and common previously associated variants. Epidemiological studies have shown TS to be correlated with other phenotypes, but large-scale phenome wide analyses in biobank level data have not been performed to date. In this study, we used the summary statistics from the latest meta-analysis of TS to calculate the polygenic risk score (PRS) of individuals in the UK Biobank data and applied a Phenome Wide Association Study (PheWAS) approach to determine the association of disease risk with a wide range of phenotypes. A total of 57 traits were found to be significantly associated with TS polygenic risk, including multiple psychosocial factors and mental health conditions such as anxiety disorder and depression. Additional associations were observed with complex non-psychiatric disorders such as Type 2 diabetes, heart palpitations, and respiratory conditions. Cross-disorder comparisons of phenotypic associations with genetic risk for other childhood-onset disorders (e.g.: attention deficit hyperactivity disorder [ADHD], autism spectrum disorder [ASD] , and obsessive-compulsive disorder [OCD]) indicated an overlap in associations between TS and these disorders. ADHD and ASD had a similar direction of effect with TS while OCD had an opposite direction of effect for all traits except mental health factors. Sex-specific PheWAS analysis identified differences in the associations with TS genetic risk between males and females. Type 2 diabetes and heart palpitations were significantly associated with TS risk in males but not in females, whereas diseases of the respiratory system were associated with TS risk in females but not in males. This analysis provides further evidence of shared genetic and phenotypic architecture of different complex disorders.

Type of Medium: Online Resource

ISSN: 2158-3188

URL: Article

DOI: 10.1038/s41398-023-02341-5

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2023

detail.hit.zdb_id: 2609311-X

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Erfreue dich Erde, Kantate

Bridgman, Frederic ; Buxtehude, Dietrich ; Kilian, Dietrich

JSTOR ; 1959

In: Revue de musicologie Vol. 43, No. 119 ( 1959-07), p. 116-

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In: Revue de musicologie, JSTOR, Vol. 43, No. 119 ( 1959-07), p. 116-

Type of Medium: Online Resource

ISSN: 0035-1601

URL: Article

DOI: 10.2307/928086

RVK:

LD 8700

Language: Unknown

Publisher: JSTOR

Publication Date: 1959

detail.hit.zdb_id: 2123412-7

SSG: 9,2

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Figure 2 from: Dietrich CH, Perkovsky EE (2019) First record of Cicadellidae (Insecta, Hemiptera, Auchenorrhyncha) from Eocene Sakhalinian amber. ZooKeys 886: 127-134. https://doi.org/10.3897/zookeys.886.38828

Dietrich, Christopher H. ; Perkovsky, Evgeny E.

Pensoft Publishers ; 2019

In: ZooKeys Vol. 886 ( 2019-11-04), p. 127-134

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In: ZooKeys, Pensoft Publishers, Vol. 886 ( 2019-11-04), p. 127-134

Abstract: Sakhalotettix eocenicus gen. & amp; sp. nov. , the first leafhopper reported from middle Eocene Sakhalinian amber, is described and illustrated. The fossil cicadellid resembles modern Xestocephalini and Bathysmatophorini in some respects but, because of its unique combination of traits, cannot be placed with certainty in either group, or in any other modern cicadellid subfamily. It is, therefore, considered to be incertae sedis within Cicadellidae.

Type of Medium: Online Resource

ISSN: 1313-2970 , 1313-2989

URL: Article

DOI: 10.3897/zookeys.886.38828

DOI: 10.3897/zookeys.886.38828.figure1

DOI: 10.3897/zookeys.886.38828.figure2

Language: Unknown

Publisher: Pensoft Publishers

Publication Date: 2019

detail.hit.zdb_id: 2445640-8

SSG: 12

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