In:
Journal of Magnetic Resonance Imaging, Wiley, Vol. 45, No. 4 ( 2017-04), p. 1186-1194
Abstract:
To assess the accuracy of the T 1 relaxation time index on gadoxetic acid‐enhanced magnetic resonance imaging (MRI) for staging liver fibrosis in chronic hepatitis B (CHB), in comparison and combination with the aspartate aminotransferase‐to‐platelet ratio index (APRI) and fibrosis‐4 (FIB‐4). Materials and Methods A retrospective study of gadoxetic acid‐enhanced T 1 mapping and serum biochemical tests was performed on 126 CHB patients who underwent gadoxetic acid‐enhanced 1.5T MRI, and the histological score used as the gold standard. The reduction rate of T 1 relaxation time before and 20 minutes after gadoxetic acid injection (Δ T 1 , ΔR1%), the contrast uptake rate (K Hep ), APRI, and FIB‐4 were calculated. The diagnostic efficacy of Δ T 1 , ΔR1%, K Hep , APRI, and FIB‐4 for predicting stage 2 or greater (≥S2), stage 3 or greater (≥S3), and stage 4 (S4) was compared. Results Δ T 1 ( r = −0.513, P 〈 0.001), ΔR1% ( r = −0.626, P 〈 0.001), K Hep ( r = −0.527, P 〈 0.001), APRI ( r = 0.519, P 〈 0.001), and FIB‐4 ( r = 0.476, P 〈 0.001) correlated significantly with fibrosis stages. Areas under the curves (AUCs) of ΔR1% for detecting ≥S2, ≥S3, and S4 were 0.849, 0.827, and 0.809, which were greater than that of APRI (0.763, 0.745, 0.787) and FIB‐4 (0.727, 0.738, 0.772), but significant difference was found only in discriminating ≥S2 between ΔR1% and FIB‐4 ( P = 0.027). The combination of all five indices performed best, with AUC, sensitivity, and specificity of 0.860, 87.21%, and 72.50% for diagnosing ≥S2, 0.878, 82.81%, and 85.48% for ≥S3, and 0.867, 80.00%, and 83.95% for S4. Conclusion The gadoxetic acid‐enhanced T 1 relaxation time index appears to be superior to APRI and FIB‐4 for predicting hepatic fibrosis. The combined use of gadoxetic acid‐enhanced T 1 mapping, APRI, and FIB‐4 may be more reliable for staging liver fibrosis in CHB. Level of Evidence: 4 J. Magn. Reson. Imaging 2017;45:1186–1194
Type of Medium:
Online Resource
ISSN:
1053-1807
,
1522-2586
Language:
English
Publisher:
Wiley
Publication Date:
2017
detail.hit.zdb_id:
1497154-9
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