In:
Journal of Heterocyclic Chemistry, Wiley, Vol. 51, No. 2 ( 2014-03), p. 404-410
Abstract:
As part of our ongoing research for molecular structures binding to the translocator protein (TSPO 18 kDa), we investigated the preparation of a number of new 2,4,5‐trisubstituted pyridines as novel building blocks. In particular, 5‐amino‐2‐halo‐4‐phenoxypyridines ( 11 , 12 , 13 ) were designed as key intermediates for the synthesis of the recently developed TSPO ligand 6‐F‐PBR28 and its fluorine‐18‐labeled version for positron emission tomography, 6‐[ 18 F]F‐PBR28. We hereby report the chemical preparation as well as the 1 H and 13 C NMR spectroscopic data of polysubstituted pyridines 2 , 3 , 4 , 5 , 6 , 7 , 7b , 8 , 9 , 10 , 11 , 12 , 13 , 14 . The latter demonstrates dramatic changes in electron density repartition of the aromatic ring upon substitution.
Type of Medium:
Online Resource
ISSN:
0022-152X
,
1943-5193
Language:
English
Publisher:
Wiley
Publication Date:
2014
detail.hit.zdb_id:
2042274-X
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