In:
International Journal of Cancer, Wiley, Vol. 133, No. 5 ( 2013-09), p. 1042-1053
Abstract:
What's new? Currently, there is no effective treatment for disseminated melanoma. In this study, the authors found that a 131 I‐labelled heteroarylcarboxamide molecule called [ 131 I]ICF01012 was effective in killing melanoma cells in an in vivo mouse model, with low toxicity. Molecular analyses of treated tumors revealed features consistent with a tumor‐cell death mechanism of mitotic catastrophe. This targeted radionuclide therapy (TRT) offers a promising alternative to conventional therapeutic agents.
Type of Medium:
Online Resource
ISSN:
0020-7136
,
1097-0215
Language:
English
Publisher:
Wiley
Publication Date:
2013
detail.hit.zdb_id:
218257-9
detail.hit.zdb_id:
1474822-8
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