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  • 1
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    “Fatty” or “steatotic”: position statement from a linguistic perspective by the Chinese-speaking community
    Elsevier BV ; 2024
    In:  Journal of Hepatology ( 2024-5)
    Details
    In: Journal of Hepatology, Elsevier BV, ( 2024-5)
    Type of Medium: Online Resource
    ISSN: 0168-8278
    URL: Article
    DOI: 10.1016/j.jhep.2024.05.031
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2024
    detail.hit.zdb_id: 2027112-8
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  • 2
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    Transcriptome dynamics of Deinococcus radiodurans recovering from ionizing radiation
    Proceedings of the National Academy of Sciences ; 2003
    In:  Proceedings of the National Academy of Sciences Vol. 100, No. 7 ( 2003-04), p. 4191-4196
    Details
    In: Proceedings of the National Academy of Sciences, Proceedings of the National Academy of Sciences, Vol. 100, No. 7 ( 2003-04), p. 4191-4196
    Abstract: Deinococcus radiodurans R1 (DEIRA) is a bacterium best known for its extreme resistance to the lethal effects of ionizing radiation, but the molecular mechanisms underlying this phenotype remain poorly understood. To define the repertoire of DEIRA genes responding to acute irradiation (15 kGy), transcriptome dynamics were examined in cells representing early, middle, and late phases of recovery by using DNA microarrays covering ≈94% of its predicted genes. At least at one time point during DEIRA recovery, 832 genes (28% of the genome) were induced and 451 genes (15%) were repressed 2-fold or more. The expression patterns of the majority of the induced genes resemble the previously characterized expression profile of recA after irradiation. DEIRA recA , which is central to genomic restoration after irradiation, is substantially up-regulated on DNA damage (early phase) and down-regulated before the onset of exponential growth (late phase). Many other genes were expressed later in recovery, displaying a growth-related pattern of induction. Genes induced in the early phase of recovery included those involved in DNA replication, repair, and recombination, cell wall metabolism, cellular transport, and many encoding uncharacterized proteins. Collectively, the microarray data suggest that DEIRA cells efficiently coordinate their recovery by a complex network, within which both DNA repair and metabolic functions play critical roles. Components of this network include a predicted distinct ATP-dependent DNA ligase and metabolic pathway switching that could prevent additional genomic damage elicited by metabolism-induced free radicals.
    Type of Medium: Online Resource
    ISSN: 0027-8424 , 1091-6490
    URL: Article
    DOI: 10.1073/pnas.0630387100
    RVK:
    TA 1000
    RVK:
    WA 15000
    Language: English
    Publisher: Proceedings of the National Academy of Sciences
    Publication Date: 2003
    detail.hit.zdb_id: 209104-5
    detail.hit.zdb_id: 1461794-8
    SSG: 11
    SSG: 12
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  • 3
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    Polarizable High‐Index Nanoparticles Used for Light‐Induced Crystal‐Silicon Passivation and Dielectric Antenna for High‐Efficiency Solar Cell
    Wiley ; 2021
    In:  Solar RRL Vol. 5, No. 7 ( 2021-07)
    Details
    In: Solar RRL, Wiley, Vol. 5, No. 7 ( 2021-07)
    Abstract: Heterojunction crystal‐silicon (c‐Si) solar cells generate current from harvesting light via sweeping excited carriers away under built‐in asymmetry through amorphous silicon layers. However, loss of energy beyond the bandgap is known to hinder their efficiency. Herein, a strategy is provided to convert short‐wavelength energy into a polarization electrical field and the light dielectric antenna effect, where enhanced surface passivation and carrier collection occur simultaneously. By depositing an ultrathin polarizable nanoparticle layer on a transparent conducting oxide (TCO), a light‐induced electrical field is built up by light‐harvesting accumulation, which benefits for c‐Si surface passivation. An enchanting open‐circuit voltage ( V oc ) of 736.6 mV for the light‐induced field‐effect solar cell is achieved. In addition, the high‐index dielectric nanoparticles generate more photons to be absorbed in the long‐wavelength in c‐Si solar cells, which results in enhanced short‐circuit current ( J sc ). As a result, benefiting from the light‐induced building‐up extra field and dielectric antenna effect, the device yields a power conversion efficiency of 22.41%, with the maximal improvement of V oc (≈4 mV), J sc (≈0.4 mA cm −2 ), and fill factor (≈1%), respectively. This work provides a strategy to enhance solar cell efficiency by continuously harvesting beyond‐bandgap light to offer an additional asymmetrical field and the light antenna effect.
    Type of Medium: Online Resource
    ISSN: 2367-198X , 2367-198X
    URL: Issue
    URL: Article
    DOI: 10.1002/solr.v5.7
    DOI: 10.1002/solr.202100169
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2882014-9
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  • 4
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    In Vitro Studies Toward the Use of Chitin as Nutraceutical: Impact on the Intestinal Epithelium, Macrophages, and Microbiota
    Wiley ; 2020
    In:  Molecular Nutrition & Food Research Vol. 64, No. 23 ( 2020-12)
    Details
    In: Molecular Nutrition & Food Research, Wiley, Vol. 64, No. 23 ( 2020-12)
    Abstract: Chitin, the most abundant polysaccharide found in nature after cellulose, is known for its ability to support wound healing and to lower plasma‐oxidized low‐density lipoprotein (LDL) levels. Studies have also revealed immunomodulatory potential but contradicting results are often impossible to coalesce through usage of chitin of different or unknown physicochemical consistency. In addition, only a limited set of cellular models have been used to test the bioactivity of chitin. Methods and Results Chitin is investigated with well‐defined physicochemical consistency for its immunomodulatory potency using THP‐1 macrophages, impact on intestinal epithelial barrier using Caco‐2 cells, and fermentation by fecal‐derived microbiota. Results show that chitin with a degree of acetylation (DA) of ≈83%, regardless of size, does not affect the intestinal epithelial barrier integrity. Large‐sized chitin significantly increases acetic acid production by gut microbiota without altering the composition. Exposure of small‐sized chitin to THP‐1 macrophages lead to significantly increased secretion of IL‐1β, IL‐8, IL‐10, and CXCL10 in a multi‐receptor and clathrin‐mediated endocytosis dependent manner. Conclusions These findings indicate that small‐sized chitin does not harm the intestinal barrier nor affects SCFA secretion and microbiota composition, but does impact immune activity which could be beneficial to subjects in need of immune support or activation.
    Type of Medium: Online Resource
    ISSN: 1613-4125 , 1613-4133
    URL: Issue
    URL: Article
    DOI: 10.1002/mnfr.v64.23
    DOI: 10.1002/mnfr.202000324
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2160372-8
    SSG: 12
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  • 5
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    Clostridium perfringens suppressing activity in black soldier fly protein preparations
    Elsevier BV ; 2021
    In:  LWT Vol. 149 ( 2021-09), p. 111806-
    Details
    In: LWT, Elsevier BV, Vol. 149 ( 2021-09), p. 111806-
    Type of Medium: Online Resource
    ISSN: 0023-6438
    URL: Article
    DOI: 10.1016/j.lwt.2021.111806
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2021
    detail.hit.zdb_id: 1469139-5
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  • 6
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    Identification of molecular subtypes and prognostic signatures based on transient receptor potential channel-related genes to predict the prognostic risk of hepatocellular carcinoma: A review
    Ovid Technologies (Wolters Kluwer Health) ; 2023
    In:  Medicine Vol. 102, No. 10 ( 2023-03-10), p. e33228-
    Details
    In: Medicine, Ovid Technologies (Wolters Kluwer Health), Vol. 102, No. 10 ( 2023-03-10), p. e33228-
    Abstract: Abnormal transient receptor potential (TRP) channel function interferes with intracellular calcium-based signaling and causes malignant phenotypes. However, the effects of TRP channel-related genes on hepatocellular carcinoma (HCC) remain unclear. This study aimed to identify HCC molecular subtypes and prognostic signatures based on TRP channel-related genes to predict prognostic risks. Unsupervised hierarchical clustering was applied to identify HCC molecular subtypes using the expression data of TRP channel-related genes. This was followed by a comparison of the clinical and immune microenvironment characteristics between the resulting subtypes. After screening for differentially expressed genes among subtypes, prognostic signatures were identified to construct risk score-based prognostic and nomogram models and predict HCC survival. Finally, tumor drug sensitivities were predicted and compared between the risk groups. Sixteen TRP channel-related genes that were differentially expressed between HCC and non-tumorous tissues were used to identify 2 subtypes. Cluster 1 had higher TRP scores, better survival status, and lower levels of clinical malignancy. Immune-related analyses also revealed higher infiltration of M1 macrophages and higher immune and stromal scores in Cluster 1 than in Cluster 2. After screening differentially expressed genes between subtypes, 6 prognostic signatures were identified to construct prognostic and nomogram models. The potential of these models to assess the prognostic risk of HCC was further validated. Furthermore, Cluster 1 was more distributed in the low-risk group, with higher drug sensitivities. Two HCC subtypes were identified, of which Cluster 1 was associated with a favorable prognosis. Prognostic signatures related to TRP channel genes and molecular subtypes can be used to predict HCC risk.
    Type of Medium: Online Resource
    ISSN: 0025-7974
    URL: Article
    DOI: 10.1097/MD.0000000000033228
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2023
    detail.hit.zdb_id: 2049818-4
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  • 7
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    Deep Time-Aware Attention Neural Network for Sequential Recommendation
    World Scientific Pub Co Pte Ltd ; 2023
    In:  Asia-Pacific Journal of Operational Research Vol. 40, No. 05 ( 2023-10)
    Details
    In: Asia-Pacific Journal of Operational Research, World Scientific Pub Co Pte Ltd, Vol. 40, No. 05 ( 2023-10)
    Abstract: For click-through rate (CTR) prediction tasks, a good prediction performance can be obtained by full explorations of both user behavior and item behavior. Since user’s interests have a great influence on user’s behaviors, it is very important to learn users’ intrinsic interests according to their behaviors. User interests are not only diverse but also in dynamic change. However, the dynamics of user interests’ change are not fully taken into account by the majority of current CTR models. The latest sequential recommendation algorithm ignores the subjectivity of users when it uses a two-layer recurrent neural network to model the item behavior from the perspective of the evolution of items. In this work, we propose a recurrent neural network model called DTIAN (Deep Time-Aware Interest Attention Network) to address these issues. By leveraging the user behaviors and the corresponding temporal information, DTIAN captures user interests and intent changes to the target item. Therefore, the users’ recent interests are enhanced compared to early interests with the attention mechanism. In addition, each module of the proposed model can be plugged into other mainstream models to improve the performance of current models. The experimental results show that the proposed DTIAN can outperform the current popular CTR prediction models slightly and significantly reduce the training time, which makes it possible to implement lightweight models.
    Type of Medium: Online Resource
    ISSN: 0217-5959 , 1793-7019
    URL: Article
    DOI: 10.1142/S0217595923400201
    Language: English
    Publisher: World Scientific Pub Co Pte Ltd
    Publication Date: 2023
    SSG: 3,2
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  • 8
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    Abstract 5622: Preclinical evaluation of humanized PD1/GITR combination therapy using double humanized mouse
    American Association for Cancer Research (AACR) ; 2022
    In:  Cancer Research Vol. 82, No. 12_Supplement ( 2022-06-15), p. 5622-5622
    Details
    In: Cancer Research, American Association for Cancer Research (AACR), Vol. 82, No. 12_Supplement ( 2022-06-15), p. 5622-5622
    Abstract: GITR (glucocorticoid-induced TNFR-related protein) is a member of tumor necrosis factor receptor superfamily, expressed on many kinds of cells including T cells, attracting attention as a co-stimulatory immune checkpoint molecule. GITRL, the ligand of GITR is mainly expressed on antigen presenting cells. GITR/GITRL interaction plays an important role on the development of immune response, which can serve as promising anti-tumor target. While more than twenty anti-GITR antibodies are at clinical stages, combination treatments of GITR agonist and PD-1 inhibitor may be a better choice. Thus, there is a need for pre-clinical mouse model to evaluate the anti-tumor effect of humanized PD1/GITR antibodies. Gempharmatech established PD1/GITR double humanized mouse line on a BALB/c background, in which the extracellular domain of mGITR was replaced with its human counterparts while the trans-membrane and cytoplasmic domain kept intact, as well as the same strategy of PD1. BALB/c-hPD1/hGITR mouse could successfully express similar levels of hGITR and hPD1 compared with BALB/c wild type mice. Moreover, no immune or developmental abnormalities were observed in the humanized mouse. Anti-GITR combination with anti-PD1 presented greater tumor growth inhibition than anti-PD1 or anti-GITR monotherapies in PD1/GITR double humanized mouse bearing CT26 tumors. In summary, BALB/c-hPD1/hGITR are valuable models for the pre-cilincal evaluation of candidate humanized PD1/GITR combination treatment or bispecific antibody therapies. Citation Format: Dongdong Yuan, Dongdong zhang, Hongyan Sun, Mingkun Zhang, Liyou Dong, Cunxiang Ju, Shuai Li, Huiyi Wang, Jing Zhao, Xiang Gao. Preclinical evaluation of humanized PD1/GITR combination therapy using double humanized mouse [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 5622.
    Type of Medium: Online Resource
    ISSN: 1538-7445
    URL: Article
    DOI: 10.1158/1538-7445.AM2022-5622
    Language: English
    Publisher: American Association for Cancer Research (AACR)
    Publication Date: 2022
    detail.hit.zdb_id: 2036785-5
    detail.hit.zdb_id: 1432-1
    detail.hit.zdb_id: 410466-3
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  • 9
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    Experimental Study on the Effective Utilization of Reserves in Tight Sandstone Gas Reservoirs and Their Applications
    Hindawi Limited ; 2020
    In:  Geofluids Vol. 2020 ( 2020-11-22), p. 1-13
    Details
    In: Geofluids, Hindawi Limited, Vol. 2020 ( 2020-11-22), p. 1-13
    Abstract: The effective utilization of reserves in tight sandstone reservoirs is one of the major concerns in terms of the development of tight sandstone gas reservoirs. However, the characteristics of reserve utilization are not fully understood, and many uncertainties still exist in the process. For this purpose, long cores on the Su 6 block of Sulige tight sandstone gas field in China were selected, and a multipoint embedded measurement system was established to study the characteristics of effective reserve utilization. Then, the effects of the related reservoir properties and production parameters were investigated. Based on the similarity theory, the effective conversion relationship between the physical experiment and the actual field production was established. The results showed that the pressure distribution in the exploitation of tight gas reservoir is nonlinear, and water cut in the reservoir will hinder the effective utilization of reserves. The lower the reservoir permeability, the larger the negative effect of water on reservoir utilization. Lower gas production rate and higher original pressure are associated with a smoother drawdown curve, which results in larger reserve utilization. The moving boundary expands with time, and its initial propagation velocity increase and then decrease. Additionally, the water cut in the reservoir can delay the spread of moving boundary propagation. The experimental results are consistent with the actual results of the field production by the similarity criterion, which can reflect and predict the production performance in tight gas reservoirs effectively. These results can provide a better understanding of reservoir pressure distribution and effective utilization of reserves to optimize the gas recovery and development benefit in tight sandstone gas reservoirs.
    Type of Medium: Online Resource
    ISSN: 1468-8123 , 1468-8115
    URL: Article
    DOI: 10.1155/2020/8854299
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2020
    detail.hit.zdb_id: 2045012-6
    SSG: 13
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  • 10
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    Online Resource
    The combined effect of vitamin K and calcium on bone mineral density in humans: a meta-analysis of randomized controlled trials
    Springer Science and Business Media LLC ; 2021
    In:  Journal of Orthopaedic Surgery and Research Vol. 16, No. 1 ( 2021-12)
    Details
    In: Journal of Orthopaedic Surgery and Research, Springer Science and Business Media LLC, Vol. 16, No. 1 ( 2021-12)
    Abstract: With the increasing incidence of osteoporosis, vitamin K and calcium have been linked to bone mineral density (BMD) and undercarboxylated osteocalcin (UcOC) in many studies, but the results of studies of the combined effect of vitamin K and calcium on BMD and UcOC in humans have been inconsistent. We conducted a systematic review of randomized controlled trials to assess the effect of this combination treatment on BMD and UcOC in humans. Methods A search for articles was conducted using PubMed, Embase, and the Cochrane Library database up to March 2021 (no language restrictions). We also reviewed the reference lists of the relevant publications and reviews to locate additional publications. The standard mean difference (SMD) was used as the primary measure of effect size. Our main endpoints were lumbar BMD, femoral neck BMD, hip BMD, total femoral BMD, and UcOC from baseline to end point. We performed subgroup analysis, heterogeneity testing, and assessment of publication bias. Results A total of 1346 patients from 10 randomized controlled trials were included in the meta-analysis. The forest plot analysis revealed that vitamin K combined with calcium was associated with a higher lumbar spine BMD compared to controls. The SMD was 0.20 [95% confidence interval (CI): 0.07 to 0.32] . Vitamin K and calcium supplementation led to a significant decrease in UcOC (SMD: − 1.71, 95% CI: − 2.45 to − 0.96). Subgroup analysis showed that vitamin K2 and vitamin K1 had SMDs of 0.30 (95% CI: 0.10 to 0.51) and SMDs of 0.14 (95% CI: − 0.02 to 0.29), and calcium dosages of ≤ 1000 mg/d or  〉  1000 mg/d had SMDs of 0.19 (95% CI: 0.05 to 0.32) and 0.26 (95% CI: − 0.04 to 0.55). Conclusion The combination of vitamin K and calcium has a positive effect on lumbar BMD and decreases the level of UcOC. Registration : The protocol for this meta-analysis was registered at the International Prospective Register of Systematic Reviews (CRD42021251825).
    Type of Medium: Online Resource
    ISSN: 1749-799X
    URL: Article
    DOI: 10.1186/s13018-021-02728-4
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2021
    detail.hit.zdb_id: 2252548-8
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