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A History of Anti-VEGF Inhibitors in the Ophthalmic Literature: A Bibliographic Review

Whitescarver, Todd D. ; Hobbs, Samuel D. ; Wade, Christian I. ; [et al.]

SAGE Publications ; 2021

In: Journal of VitreoRetinal Diseases Vol. 5, No. 4 ( 2021-07), p. 304-312

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In: Journal of VitreoRetinal Diseases, SAGE Publications, Vol. 5, No. 4 ( 2021-07), p. 304-312

Abstract: This work aimed to analyze the 100 most-cited articles on antivascular endothelial growth factor (anti-VEGF) inhibitors. Methods: A literature search for anti-VEGF inhibitors using the Web of Science was completed using the bibliographic databases for peer-reviewed literature published in Ophthalmology, the New England Journal of Medicine, Journal of the American Medical Association, and Lancet. Primary outcomes were the most frequently cited articles and journals with the most citations as well as the specific drug and disease process studied. Results: There were 42 696 cumulative citations among the top 100 articles. The articles were published between 2004 to 2016, with most articles published in 2006. Ophthalmology published the greatest number of articles among the top 100 at 48, whereas the New England Journal of Medicine has the most citations per publication at 1714. Ranibizumab was the medication researched in most articles at 56, followed by bevacizumab at 48, aflibercept at 10, and pegaptanib at 9. Forty-two articles investigated treatment of age-related macular degeneration, followed by 24 investigating diabetic macular edema, 10 for retinal vein occlusion, 8 for proliferative diabetic retinopathy, 2 for retinopathy of prematurity and polypoidal choroidal vasculopathy, and 1 for corneal neovascularization. Conclusions: As evidenced by the considerable number of citations accumulated over the past 20 years, anti-VEGF inhibitors have led to significant research in ophthalmology.

Type of Medium: Online Resource

ISSN: 2474-1264 , 2474-1272

URL: Article

DOI: 10.1177/2474126420971982

Language: English

Publisher: SAGE Publications

Publication Date: 2021

detail.hit.zdb_id: 2898183-2

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Genetic mapping of the human X chromosome by using restriction fragment length polymorphisms.

Drayna, D ; Davies, K ; Hartley, D ; [et al.]

Proceedings of the National Academy of Sciences ; 1984

In: Proceedings of the National Academy of Sciences Vol. 81, No. 9 ( 1984-05), p. 2836-2839

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In: Proceedings of the National Academy of Sciences, Proceedings of the National Academy of Sciences, Vol. 81, No. 9 ( 1984-05), p. 2836-2839

Abstract: Using a human X chromosome-specific DNA library, we have found arbitrary single-copy DNA sequences that reveal useful restriction fragment length polymorphisms. The inheritance of these and other available polymorphic DNA markers has been studied in a series of unrelated three-generation families with large sibships. These families reveal parental phase and allow determination of recombination frequencies by counting recombinant and nonrecombinant chromosomes. The resulting genetic map indicates that the minimal distance from Xp22 to Xqter is 215 recombination units. The spacing of the marker loci is such that the majority of the loci on the X chromosome, including disease loci, will lie within 20 centimorgans of at least one of these loci.

Type of Medium: Online Resource

ISSN: 0027-8424 , 1091-6490

URL: Article

DOI: 10.1073/pnas.81.9.2836

RVK:

TA 1000

RVK:

WA 15000

Language: English

Publisher: Proceedings of the National Academy of Sciences

Publication Date: 1984

detail.hit.zdb_id: 209104-5

detail.hit.zdb_id: 1461794-8

SSG: 11

SSG: 12

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Evolution of Functionally Diverse Alleles Associated with PTC Bitter Taste Sensitivity in Africa

Campbell, M. C. ; Ranciaro, A. ; Froment, A. ; [et al.]

Oxford University Press (OUP) ; 2012

In: Molecular Biology and Evolution Vol. 29, No. 4 ( 2012-04-01), p. 1141-1153

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In: Molecular Biology and Evolution, Oxford University Press (OUP), Vol. 29, No. 4 ( 2012-04-01), p. 1141-1153

Type of Medium: Online Resource

ISSN: 0737-4038 , 1537-1719

URL: Article

DOI: 10.1093/molbev/msr293

Language: English

Publisher: Oxford University Press (OUP)

Publication Date: 2012

detail.hit.zdb_id: 2024221-9

SSG: 12

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Genetics of Human Taste Perception

Kim, U.-K. ; Breslin, P.A.S. ; Reed, D. ; [et al.]

SAGE Publications ; 2004

In: Journal of Dental Research Vol. 83, No. 6 ( 2004-06), p. 448-453

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In: Journal of Dental Research, SAGE Publications, Vol. 83, No. 6 ( 2004-06), p. 448-453

Abstract: Genetic approaches are rapidly yielding new information about our sense of taste. This information comes from both molecular studies of genes encoding taste receptors and other taste-signaling components, and from studies of inherited variation in taste abilities. Our understanding of bitter taste has advanced by combined information from discovery and study of the TAS2R family of taste receptor genes, hand in hand with genetic linkage and positional cloning studies, notably on the ability to taste phenylthiocarbamide (PTC). Sweet and umami tastes, mediated by TAS1R receptors, are becoming well-characterized at the molecular genetic level, and these taste classes are now targets for linkage, positional cloning, and genetic association strategies. Salty and sour tastes are still poorly characterized in genetic terms, and represent opportunities for the future.

Type of Medium: Online Resource

ISSN: 0022-0345 , 1544-0591

URL: Article

DOI: 10.1177/154405910408300603

Language: English

Publisher: SAGE Publications

Publication Date: 2004

detail.hit.zdb_id: 2057074-0

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A genetic linkage study in Brazil identifies a new locus for persistent developmental stuttering on chromosome 10

Domingues, C.E.F. ; Olivera, C.M.C. ; Oliveira, B.V. ; [et al.]

Genetics and Molecular Research ; 2014

In: Genetics and Molecular Research Vol. 13, No. 1 ( 2014), p. 2094-2101

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In: Genetics and Molecular Research, Genetics and Molecular Research, Vol. 13, No. 1 ( 2014), p. 2094-2101

Type of Medium: Online Resource

ISSN: 1676-5680

URL: Article

DOI: 10.4238/2014.March.24.13

Language: Unknown

Publisher: Genetics and Molecular Research

Publication Date: 2014

detail.hit.zdb_id: 2114039-X

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Human GNPTAB stuttering mutations engineered into mice cause vocalization deficits and astrocyte pathology in the corpus callosum

Han, Tae-Un ; Root, Jessica ; Reyes, Laura D. ; [et al.]

Proceedings of the National Academy of Sciences ; 2019

In: Proceedings of the National Academy of Sciences Vol. 116, No. 35 ( 2019-08-27), p. 17515-17524

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In: Proceedings of the National Academy of Sciences, Proceedings of the National Academy of Sciences, Vol. 116, No. 35 ( 2019-08-27), p. 17515-17524

Abstract: Stuttering is a common neurodevelopmental disorder that has been associated with mutations in genes involved in intracellular trafficking. However, the cellular mechanisms leading to stuttering remain unknown. Engineering a mutation in N -acetylglucosamine-1-phosphate transferase subunits α and β (GNPTAB) found in humans who stutter into the mouse Gnptab gene resulted in deficits in the flow of ultrasonic vocalizations similar to speech deficits of humans who stutter. Here we show that other human stuttering mutations introduced into this mouse gene, Gnptab Ser321Gly and Ala455Ser, produce the same vocalization deficit in 8-day-old pup isolation calls and do not affect other nonvocal behaviors. Immunohistochemistry showed a marked decrease in staining of astrocytes, particularly in the corpus callosum of the Gnptab Ser321Gly homozygote mice compared to wild-type littermates, while the staining of cerebellar Purkinje cells, oligodendrocytes, microglial cells, and dopaminergic neurons was not significantly different. Diffusion tensor imaging also detected deficits in the corpus callosum of the Gnptab Ser321Gly mice. Using a range of cell type-specific Cre-drivers and a Gnptab conditional knockout line, we found that only astrocyte-specific Gnptab -deficient mice displayed a similar vocalization deficit. These data suggest that vocalization defects in mice carrying human stuttering mutations in Gnptab derive from abnormalities in astrocytes, particularly in the corpus callosum, and provide support for hypotheses that focus on deficits in interhemispheric communication in stuttering.

Type of Medium: Online Resource

ISSN: 0027-8424 , 1091-6490

URL: Article

DOI: 10.1073/pnas.1901480116

RVK:

TA 1000

RVK:

WA 15000

Language: English

Publisher: Proceedings of the National Academy of Sciences

Publication Date: 2019

detail.hit.zdb_id: 209104-5

detail.hit.zdb_id: 1461794-8

SSG: 11

SSG: 12

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Helicopter Interfacility Transport of Pediatric Trauma Patients: Are We Overutilizing a Costly Resource?

Meyer, Michael T. ; Gourlay, David M. ; Weitze, Keith C. ; [et al.]

American Academy of Pediatrics (AAP) ; 2016

In: Pediatrics Vol. 137, No. Supplement 3 ( 2016-02), p. 618A-618A

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In: Pediatrics, American Academy of Pediatrics (AAP), Vol. 137, No. Supplement 3 ( 2016-02), p. 618A-618A

Type of Medium: Online Resource

ISSN: 0031-4005 , 1098-4275

URL: Article

DOI: 10.1542/peds.137.Supplement_3.618A

Language: English

Publisher: American Academy of Pediatrics (AAP)

Publication Date: 2016

detail.hit.zdb_id: 1477004-0

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Fully-automated segmentation of fluid regions in exudative age-related macular degeneration subjects: Kernel graph cut in neutrosophic domain

Rashno, Abdolreza ; Nazari, Behzad ; Koozekanani, Dara D. ; [et al.]

Public Library of Science (PLoS) ; 2017

In: PLOS ONE Vol. 12, No. 10 ( 2017-10-23), p. e0186949-

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In: PLOS ONE, Public Library of Science (PLoS), Vol. 12, No. 10 ( 2017-10-23), p. e0186949-

Type of Medium: Online Resource

ISSN: 1932-6203

URL: Article

DOI: 10.1371/journal.pone.0186949

DOI: 10.1371/journal.pone.0186949.g001

DOI: 10.1371/journal.pone.0186949.g002

DOI: 10.1371/journal.pone.0186949.g003

DOI: 10.1371/journal.pone.0186949.g004

DOI: 10.1371/journal.pone.0186949.g005

DOI: 10.1371/journal.pone.0186949.g006

DOI: 10.1371/journal.pone.0186949.g007

DOI: 10.1371/journal.pone.0186949.g008

DOI: 10.1371/journal.pone.0186949.g009

DOI: 10.1371/journal.pone.0186949.g010

DOI: 10.1371/journal.pone.0186949.g011

DOI: 10.1371/journal.pone.0186949.g012

DOI: 10.1371/journal.pone.0186949.g013

DOI: 10.1371/journal.pone.0186949.g014

DOI: 10.1371/journal.pone.0186949.g015

DOI: 10.1371/journal.pone.0186949.g016

DOI: 10.1371/journal.pone.0186949.t001

DOI: 10.1371/journal.pone.0186949.t002

DOI: 10.1371/journal.pone.0186949.t003

DOI: 10.1371/journal.pone.0186949.t004

DOI: 10.1371/journal.pone.0186949.t005

DOI: 10.1371/journal.pone.0186949.t006

DOI: 10.1371/journal.pone.0186949.t007

Language: English

Publisher: Public Library of Science (PLoS)

Publication Date: 2017

detail.hit.zdb_id: 2267670-3

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Cloning and expression of human apolipoprotein D cDNA.

Drayna, D ; Fielding, C ; McLean, J ; [et al.]

Elsevier BV ; 1986

In: Journal of Biological Chemistry Vol. 261, No. 35 ( 1986-12), p. 16535-16539

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In: Journal of Biological Chemistry, Elsevier BV, Vol. 261, No. 35 ( 1986-12), p. 16535-16539

Type of Medium: Online Resource

ISSN: 0021-9258

URL: Article

DOI: 10.1016/S0021-9258(18)66599-8

Language: English

Publisher: Elsevier BV

Publication Date: 1986

detail.hit.zdb_id: 2141744-1

detail.hit.zdb_id: 1474604-9

SSG: 12

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Genetic dissection of human taste perception

Fushan, A. ; Mckluskey, S. ; Simons, C. ; [et al.]

Elsevier BV ; 2008

In: Appetite Vol. 51, No. 2 ( 2008-9), p. 366-

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In: Appetite, Elsevier BV, Vol. 51, No. 2 ( 2008-9), p. 366-

Type of Medium: Online Resource

ISSN: 0195-6663

URL: Article

DOI: 10.1016/j.appet.2008.04.085

Language: English

Publisher: Elsevier BV

Publication Date: 2008

detail.hit.zdb_id: 1461347-5

SSG: 12

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