In:
Journal of Neuroimaging, Wiley, Vol. 20, No. 1 ( 2010-01), p. 53-57
Abstract:
Diameter measurement of the third ventricle with magnetic resonance imaging (MRI) and recently also with transcranial sonography (TCS) has emerged as a surrogate marker for brain atrophy and disease progression in multiple sclerosis (MS). This study aims to evaluate TCS measurements of the third ventricle diameter in a clinical routine setting against MRI. METHODS Transverse diameters of the third ventricle were determined in 27 MS patients using both, TCS and MRI. In TCS, the distance between the leading edges of the brain‐ventricle interfaces was assessed in axial image planes. In MRI, the transverse diameter of the mid‐portion of the third ventricle was measured on axial T1‐weighted images. RESULTS The mean diameter of the third ventricle was 4.0 mm (SD 1.7 mm), when measured with MRI, and 4.4 mm (SD 1.7 mm), when measured with TCS. The 95% limits of agreement of the Bland‐Altman Plot were 2.93 mm (95% CI 2.08 to 3.78 mm) and −2.23 mm (95%CI −3.08 to −1.38 mm). Pearson correlation coefficient was .71 ( P 〈 .0001). CONCLUSIONS TCS may appear suitable as screening examination for the extent of brain atrophy at a single‐point study, but at least in the early stages of the disease, TCS is not useful to monitor disease progression. J Neuroimaging 2010;20:53‐57.
Type of Medium:
Online Resource
ISSN:
1051-2284
,
1552-6569
DOI:
10.1111/jon.2010.20.issue-1
DOI:
10.1111/j.1552-6569.2008.00321.x
Language:
English
Publisher:
Wiley
Publication Date:
2010
detail.hit.zdb_id:
1071724-9
detail.hit.zdb_id:
2035400-9
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