In:
The Journal of Infectious Diseases, Oxford University Press (OUP), Vol. 224, No. 3 ( 2021-08-02), p. 492-502
Abstract:
We assessed the association between serum 25-hydroxyvitamin D levels and genital human papillomavirus (HPV) prevalence, incidence, and clearance among female participants in the HPV Infection and Transmission among Couples through Heterosexual activity (HITCH) Cohort Study. Methods We genotyped HPV DNA in vaginal samples and quantified baseline serum 25-hydroxyvitamin D levels using Roche’s Linear Array and Total vitamin D assay, respectively. We used logistic and Cox proportional hazards models, respectively, to estimate adjusted odds ratios (ORs) and hazard ratios (HRs) with 95% confidence intervals (CIs). Results There was no association between vitamin D levels (every 10-ng/mL increase) at baseline and HPV prevalence (OR, 0.88; 95% CI, .73–1.03) or incidence (HR, 0.88; 95% CI, .73–1.06), but we observed a modest negative association with HPV clearance (HR, 0.76; 95% CI, .60–.96). Vitamin D levels & lt;30 ng/mL, compared with those ≥30 ng/mL, were not associated with HPV prevalence (OR, 0.98; 95% CI, .57–1.69) or incidence (HR, .87; 95% CI, .50–1.43), but they were associated with a marginally significant increased clearance (OR, 2.14; 95% CI, .99–4.64). We observed consistent results with restricted cubic spline modeling of vitamin D levels and clinically defined categories. HPV type-specific analyses accounting for multiple HPV infections per participant showed no association between vitamin D levels and all study outcomes. Conclusions This study provided no evidence of an association between low vitamin D levels and increased HPV prevalence, acquisition, or clearance.
Type of Medium:
Online Resource
ISSN:
0022-1899
,
1537-6613
DOI:
10.1093/infdis/jiaa758
Language:
English
Publisher:
Oxford University Press (OUP)
Publication Date:
2021
detail.hit.zdb_id:
1473843-0
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