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Clinical features and prognostic factors of listeriosis: the MONALISA national prospective cohort study

Charlier, Caroline ; Perrodeau, Élodie ; Leclercq, Alexandre ; [et al.]

Elsevier BV ; 2017

In: The Lancet Infectious Diseases Vol. 17, No. 5 ( 2017-05), p. 510-519

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In: The Lancet Infectious Diseases, Elsevier BV, Vol. 17, No. 5 ( 2017-05), p. 510-519

Type of Medium: Online Resource

ISSN: 1473-3099

URL: Article

DOI: 10.1016/S1473-3099(16)30521-7

Language: English

Publisher: Elsevier BV

Publication Date: 2017

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2

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Immunovirological status in people with perinatal and adult-acquired HIV-1 infection: a multi-cohort analysis from France

Seng, Rémonie ; Frange, Pierre ; Faye, Albert ; [et al.]

Elsevier BV ; 2024

In: The Lancet Regional Health - Europe Vol. 40 ( 2024-05), p. 100885-

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In: The Lancet Regional Health - Europe, Elsevier BV, Vol. 40 ( 2024-05), p. 100885-

Type of Medium: Online Resource

ISSN: 2666-7762

URL: Article

DOI: 10.1016/j.lanepe.2024.100885

Language: English

Publisher: Elsevier BV

Publication Date: 2024

detail.hit.zdb_id: 3055963-7

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3

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In-Depth Characterization of Full-Length Archived Viral Genomes after Nine Years of Posttreatment HIV Control

Trémeaux, Pauline ; Lemoine, Frédéric ; Mélard, Adeline ; [et al.]

American Society for Microbiology ; 2023

In: Microbiology Spectrum Vol. 11, No. 1 ( 2023-02-14)

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In: Microbiology Spectrum, American Society for Microbiology, Vol. 11, No. 1 ( 2023-02-14)

Abstract: In the search for control of human immunodeficiency virus type 1 (HIV-1) infection without antiretroviral therapy, posttreatment controllers (PTCs) are models of HIV remission. To better understand their mechanisms of control, we characterized the HIV blood reservoirs of 8 PTCs (median of 9.4 years after treatment interruption) in comparison with those of 13 natural HIV infection controllers (HICs) (median of 18 years of infection) and with those of individuals receiving efficient antiretroviral therapy initiated during either primary HIV infection (PHIs; n = 8) or chronic HIV infection (CHIs; n = 6). This characterization was performed with single-genome amplification and deep sequencing. The proviral diversity, which reflects the history of past viral replication, was lower in the PTCs, PHIs, and aviremic HICs than in the blipper HICs and CHIs. The proportions of intact and defective proviruses among the proviral pool in PTCs were not significantly different from those of other groups. When looking at the quantities of proviruses per million peripheral blood mononuclear cells (PBMCs), they had similar amounts of intact proviruses as other groups but smaller amounts of defective proviruses than CHIs, suggesting a role of these forms in HIV pathogenesis. Two HICs but none of the PTCs harbored only proviruses with deletion in nef ; these attenuated strains could contribute to viral control in these participants. We show, for the first time, the presence of intact proviruses and low viral diversity in PTCs long after treatment interruption, as well as the absence of evolution of the proviral quasispecies in subsequent samples. This reflects low residual replication over time. Further data are necessary to confirm these results. IMPORTANCE Most people living with HIV need antiretroviral therapy to control their infection and experience viral relapse in case of treatment interruption, because of viral reservoir (proviruses) persistence. Knowing that proviruses are very diverse and most of them are defective in treated individuals, we aimed to characterize the HIV blood reservoirs of posttreatment controllers (PTCs), rare models of drug-free remission, in comparison with spontaneous controllers and treated individuals. At a median time of 9 years after treatment interruption, which is unprecedented in the literature, we showed that the proportions and quantities of intact proviruses were similar between PTCs and other individuals. Unlike 2/7 spontaneous controllers who harbored only nef -deleted proviruses, which are attenuated strains, which could contribute to their control, no such case was observed in PTCs. Furthermore, PTCs displayed low viral genetic diversity and no evolution of their reservoirs, indicating very low residual replication, despite the presence of intact proviruses.

Type of Medium: Online Resource

ISSN: 2165-0497

URL: Article

DOI: 10.1128/spectrum.03267-22

Language: English

Publisher: American Society for Microbiology

Publication Date: 2023

detail.hit.zdb_id: 2807133-5

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4

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Maintenance darunavir/ritonavir monotherapy to prevent perinatal HIV transmission, ANRS-MIE 168 MONOGEST study

Mandelbrot, Laurent ; Tubiana, Roland ; Frange, Pierre ; [et al.]

Oxford University Press (OUP) ; 2023

In: Journal of Antimicrobial Chemotherapy Vol. 78, No. 7 ( 2023-07-05), p. 1711-1722

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In: Journal of Antimicrobial Chemotherapy, Oxford University Press (OUP), Vol. 78, No. 7 ( 2023-07-05), p. 1711-1722

Abstract: Because NRTIs can have fetal toxicities, we evaluated a perinatal NRTI-sparing strategy to prevent perinatal HIV transmission. Our primary objective was to determine the proportion maintaining a viral load (VL) of & lt;50 copies/mL up to delivery on darunavir/ritonavir monotherapy, without requiring treatment intensification. Methods In a one-arm, multicentre Phase 2 clinical trial, eligible patients in the first trimester of pregnancy on ART with plasma VL & lt; 50 copies/mL received maintenance monotherapy with darunavir/ritonavir, 600/100 mg twice daily. VL was monitored monthly. ART was intensified in the case of VL & gt; 50 copies/mL. Neonates received nevirapine prophylaxis for 14 days. Results Of 89 patients switching to darunavir/ritonavir monotherapy, 4 miscarried before 22 weeks’ gestation, 2 changed treatment for elevated liver enzymes without virological failure, and 83 were evaluable for the main outcome. Six had virological failure confirmed on a repeat sample (median VL = 193 copies/mL; range 78–644), including two before switching to monotherapy. In these six cases, ART was intensified with tenofovir disoproxil fumarate/emtricitabine. The success rate was 75/83, 90.4% (95% CI, 81.9%–95.7%) considering two patients with VL missing at delivery as failures, and 77/83, 92.8% (95% CI, 84.9%–97.3%) when considering them as successes since both had undetectable VL on darunavir/ritonavir throughout pregnancy. In ITT, the last available VL before delivery was & lt;50 copies/mL in all of the patients. There was no case of perinatal HIV transmission. Conclusions Darunavir/ritonavir maintenance monotherapy required intensification in nearly 10% of cases. This limits its widespread use, thus other regimens should be evaluated in order to limit exposure to antiretrovirals, particularly NRTIs, during pregnancy.

Type of Medium: Online Resource

ISSN: 0305-7453 , 1460-2091

URL: Article

DOI: 10.1093/jac/dkad161

Language: English

Publisher: Oxford University Press (OUP)

Publication Date: 2023

detail.hit.zdb_id: 1467478-6

SSG: 15,3

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5

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Apolipoprotein B-100 gene mutations and cholesterol control in German patients

Loggen, Ursula ; Boden, Anja ; Baron, Heike ; [et al.]

Elsevier BV ; 2003

In: Atherosclerosis Vol. 166, No. 2 ( 2003-2), p. 411-412

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In: Atherosclerosis, Elsevier BV, Vol. 166, No. 2 ( 2003-2), p. 411-412

Type of Medium: Online Resource

ISSN: 0021-9150

URL: Article

DOI: 10.1016/S0021-9150(02)00377-5

Language: English

Publisher: Elsevier BV

Publication Date: 2003

detail.hit.zdb_id: 1499887-7

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6

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Prevalence of Mycoplasma genitalium Among HIV-Infected Women, Agence Nationale de Recherches sur le SIDA et les hépatites virales CO3 Aquitaine Cohort, France

Cazanave, Charles ; Lawson-Ayayi, Sylvie ; Hessamfar, Mojgan ; [et al.]

Ovid Technologies (Wolters Kluwer Health) ; 2013

In: Sexually Transmitted Diseases Vol. 40, No. 8 ( 2013-08), p. 653-654

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In: Sexually Transmitted Diseases, Ovid Technologies (Wolters Kluwer Health), Vol. 40, No. 8 ( 2013-08), p. 653-654

Type of Medium: Online Resource

ISSN: 0148-5717

URL: Article

DOI: 10.1097/01.OLQ.0000431360.03712.1b

Language: English

Publisher: Ovid Technologies (Wolters Kluwer Health)

Publication Date: 2013

detail.hit.zdb_id: 2055170-8

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7

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Combined Molecular and Clinical Approaches for the Identification of Families with Familial Adenomatous Polyposis Coli

Gebert, Johannes F. ; Dupon, Cecile ; Kadmon, Martina ; [et al.]

Ovid Technologies (Wolters Kluwer Health) ; 1999

In: Annals of Surgery Vol. 229, No. 3 ( 1999-03), p. 350-361

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In: Annals of Surgery, Ovid Technologies (Wolters Kluwer Health), Vol. 229, No. 3 ( 1999-03), p. 350-361

Type of Medium: Online Resource

ISSN: 0003-4932

URL: Article

DOI: 10.1097/00000658-199903000-00008

RVK:

XA 23900

Language: English

Publisher: Ovid Technologies (Wolters Kluwer Health)

Publication Date: 1999

detail.hit.zdb_id: 2002200-1

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8

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Absence of Decline of Kidney Function in Human Immunodeficiency Virus-Infected Patients Under Routine Clinical Management

Boucquemont, Julie ; Lawson-Ayayi, Sylvie ; Rigothier, Claire ; [et al.]

S. Karger AG ; 2017

In: Nephron Vol. 136, No. 3 ( 2017), p. 211-220

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In: Nephron, S. Karger AG, Vol. 136, No. 3 ( 2017), p. 211-220

Abstract: 〈 b 〉 〈 i 〉 Background: 〈 /i 〉 〈 /b 〉 Since the introduction of antiretroviral therapy (ART), human immunodeficiency virus (HIV)-infected patients have a drastically improved prognosis but at the same time they are also more affected by non-HIV related complications, such as chronic kidney disease. The objective of our study was to investigate the effect of proteinuria and tenofovir (TDF)-containing ART regimens on the temporal evolution of estimated glomerular filtration rate (eGFR). 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 Between April 2008 and October 2012, we enrolled 395 patients with a complete renal evaluation among patients from the ANRS C03 Aquitaine cohort, a prospective hospital-based cohort of HIV-1-infected patients under routine clinical management in southwestern France. eGFR was estimated at each patient follow-up visit. A linear mixed model was used to analyze eGFR dynamics, accounting for change in TDF by modeling eGFR trajectory according to treatment periods. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 At inclusion, 56.7% of patients were treated with TDF-containing ART regimens; prevalence of glomerular and tubular proteinuria was 7.9 and 10.8% respectively. A 1-year increase of cumulative exposure to TDF was significantly associated with a mean eGFR decrease of 1.27 mL/min/1.73 m 〈 sup 〉 2 〈 /sup 〉 (95% CI [-2.14 to -0.41]). Only a urine protein to creatinine ratio 〉 100 mg/mmol and/or a urine albumin to creatinine ratio 〉 70 mg/mmol were associated with eGFR trajectory (mean slope 6.18 mL/min/1.73 m 〈 sup 〉 2 〈 /sup 〉 per year; 95% CI [2.71 to 9.65]), whereas TDF use was not associated with such eGFR temporal evolution. 〈 b 〉 〈 i 〉 Conclusion: 〈 /i 〉 〈 /b 〉 Decline in kidney function is limited under routine clinical management with monitoring of renal function and interventions including decision to continue or discontinue TDF.

Type of Medium: Online Resource

ISSN: 1660-8151 , 2235-3186

URL: Article

DOI: 10.1159/000467400

Language: English

Publisher: S. Karger AG

Publication Date: 2017

detail.hit.zdb_id: 2810853-X

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Variable-number tandem-repeat markers for typing Mycobacterium intracellulare strains isolated in humans

Dauchy, Frédéric-Antoine ; Dégrange, Sébastien ; Charron, Alain ; [et al.]

Springer Science and Business Media LLC ; 2010

In: BMC Microbiology Vol. 10, No. 1 ( 2010), p. 93-

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In: BMC Microbiology, Springer Science and Business Media LLC, Vol. 10, No. 1 ( 2010), p. 93-

Type of Medium: Online Resource

ISSN: 1471-2180

URL: Article

DOI: 10.1186/1471-2180-10-93

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2010

detail.hit.zdb_id: 2041505-9

SSG: 12

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Population pharmacokinetics and pharmacogenetics of ritonavir-boosted darunavir in the presence of raltegravir or tenofovir disoproxil fumarate/emtricitabine in HIV-infected adults and the relationship with virological response: a sub-study of the NEAT001/ANRS143 randomized trial

Dickinson, Laura ; Gurjar, Rohan ; Stöhr, Wolfgang ; [et al.]

Oxford University Press (OUP) ; 2020

In: Journal of Antimicrobial Chemotherapy Vol. 75, No. 3 ( 2020-03-01), p. 628-639

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In: Journal of Antimicrobial Chemotherapy, Oxford University Press (OUP), Vol. 75, No. 3 ( 2020-03-01), p. 628-639

Abstract: NEAT001/ANRS143 demonstrated non-inferiority of once-daily darunavir/ritonavir (800/100 mg) + twice-daily raltegravir (400 mg) versus darunavir/ritonavir + tenofovir disoproxil fumarate/emtricitabine (245/200 mg once daily) in treatment-naive patients. We investigated the population pharmacokinetics of darunavir, ritonavir, tenofovir and emtricitabine and relationships with demographics, genetic polymorphisms and virological failure. Methods Non-linear mixed-effects models (NONMEM v. 7.3) were applied to determine pharmacokinetic parameters and assess demographic covariates and relationships with SNPs (SLCO3A1, SLCO1B1, NR1I2, NR1I3, CYP3A5*3, CYP3A4*22, ABCC2, ABCC10, ABCG2 and SCL47A1). The relationship between model-predicted darunavir AUC0–24 and C24 with time to virological failure was evaluated by Cox regression. Results Of 805 enrolled, 716, 720, 347 and 361 were included in the darunavir, ritonavir, tenofovir and emtricitabine models, respectively (11% female, 83% Caucasian). No significant effect of patient demographics or SNPs was observed for darunavir or tenofovir apparent oral clearance (CL/F); coadministration of raltegravir did not influence darunavir or ritonavir CL/F. Ritonavir CL/F decreased by 23% in NR1I2 63396C & gt;T carriers and emtricitabine CL/F was linearly associated with creatinine clearance (P & lt;0.001). No significant relationship was demonstrated between darunavir AUC0–24 or C24 and time to virological failure [HR (95% CI): 2.28 (0.53–9.80), P=0.269; and 1.82 (0.61–5.41), P=0.279, respectively]. Conclusions Darunavir concentrations were unaltered in the presence of raltegravir and not associated with virological failure. Polymorphisms investigated had little impact on study-drug pharmacokinetics. Darunavir/ritonavir + raltegravir may be an appropriate option for patients experiencing NRTI-associated toxicity.

Type of Medium: Online Resource

ISSN: 0305-7453 , 1460-2091

URL: Article

DOI: 10.1093/jac/dkz479

Language: English

Publisher: Oxford University Press (OUP)

Publication Date: 2020

detail.hit.zdb_id: 1467478-6

SSG: 15,3

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Berlin Brandenburg