In:
Journal of Clinical Oncology, American Society of Clinical Oncology (ASCO), Vol. 25, No. 18_suppl ( 2007-06-20), p. 589-589
Abstract:
589 Background: Dynamic contrast-enhanced MRI (DCE-MRI) and positron emission tomography (PET) are two imaging modalities previously shown to be predictive of response to neoadjuvant therapy in breast cancer. As the two techniques are functionally very different, the extent of their agreement or discordance for tumor characterization is not well understood. The purpose of this study was therefore to investigate the association between quantitative DCE-MRI enhancement kinetics and 15 O-water PET/ 18 F-FDG PET blood flow and metabolic measures of breast tumors. Methods: We retrospectively evaluated exams for 20 patients with locally advanced breast cancer (LABC) who underwent both 15 O-water/ 18 F-FDG PET and DCE-MRI. PET measures included 15 O-water blood flow, 18 F-FDG transport rate constant from blood to tissue (K 1 ), and FDG metabolic rate. DCE-MRI measures included functional tumor volume, initial peak enhancement (PE), and a delayed signal enhancement ratio (SER) assessing washout. Pearson’s correlations and multivariate stepwise regression analyses were performed; p 〈 0.05 was considered significant. Results: PET 15 O-water blood flow correlated significantly with DCE-MRI peak SER (r=0.8) and tumor volume (r=0.7). PET K 1 measures correlated significantly with DCE-MRI peak PE (r=0.7), peak SER (r=0.6) and tumor volume (r=0.6). By multivariate analysis, SER was the strongest independent MRI correlate of PET blood flow, and PE the strongest MRI correlate for K 1 . No significant correlations were observed between 18 F-FDG PET metabolic rate and the DCE-MRI kinetic parameters. Also, while blood flow and K 1 were strongly correlated (r=0.9, p=0.0001), blood flow and metabolic rate were not (r=0.4, p=0.12). Conclusions: The associations between PET and MRI measures may lead to a better understanding of angiogenesis, vascular permeability, and glucose transport in LABC. A lack of correlation of metabolic rate with blood flow and DCE MRI kinetics suggests that 18 F-FDG PET provides complimentary metabolic information independent of vascular factors. The combination of MRI and PET may be helpful in understanding tumor pharmacodynamics in response to novel therapy. No significant financial relationships to disclose.
Type of Medium:
Online Resource
ISSN:
0732-183X
,
1527-7755
DOI:
10.1200/jco.2007.25.18_suppl.589
Language:
English
Publisher:
American Society of Clinical Oncology (ASCO)
Publication Date:
2007
detail.hit.zdb_id:
2005181-5
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