Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    In: G3 Genes|Genomes|Genetics, Oxford University Press (OUP), Vol. 5, No. 5 ( 2015-05-01), p. 719-740
    Abstract: The Muller F element (4.2 Mb, ~80 protein-coding genes) is an unusual autosome of Drosophila melanogaster; it is mostly heterochromatic with a low recombination rate. To investigate how these properties impact the evolution of repeats and genes, we manually improved the sequence and annotated the genes on the D. erecta, D. mojavensis, and D. grimshawi F elements and euchromatic domains from the Muller D element. We find that F elements have greater transposon density (25–50%) than euchromatic reference regions (3–11%). Among the F elements, D. grimshawi has the lowest transposon density (particularly DINE-1: 2% vs. 11–27%). F element genes have larger coding spans, more coding exons, larger introns, and lower codon bias. Comparison of the Effective Number of Codons with the Codon Adaptation Index shows that, in contrast to the other species, codon bias in D. grimshawi F element genes can be attributed primarily to selection instead of mutational biases, suggesting that density and types of transposons affect the degree of local heterochromatin formation. F element genes have lower estimated DNA melting temperatures than D element genes, potentially facilitating transcription through heterochromatin. Most F element genes (~90%) have remained on that element, but the F element has smaller syntenic blocks than genome averages (3.4–3.6 vs. 8.4–8.8 genes per block), indicating greater rates of inversion despite lower rates of recombination. Overall, the F element has maintained characteristics that are distinct from other autosomes in the Drosophila lineage, illuminating the constraints imposed by a heterochromatic milieu.
    Type of Medium: Online Resource
    ISSN: 2160-1836
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2015
    detail.hit.zdb_id: 2629978-1
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 2
    In: Database, Oxford University Press (OUP), Vol. 2019 ( 2019-01-01)
    Abstract: Document recommendation systems for locating relevant literature have mostly relied on methods developed a decade ago. This is largely due to the lack of a large offline gold-standard benchmark of relevant documents that cover a variety of research fields such that newly developed literature search techniques can be compared, improved and translated into practice. To overcome this bottleneck, we have established the RElevant LIterature SearcH consortium consisting of more than 1500 scientists from 84 countries, who have collectively annotated the relevance of over 180 000 PubMed-listed articles with regard to their respective seed (input) article/s. The majority of annotations were contributed by highly experienced, original authors of the seed articles. The collected data cover 76% of all unique PubMed Medical Subject Headings descriptors. No systematic biases were observed across different experience levels, research fields or time spent on annotations. More importantly, annotations of the same document pairs contributed by different scientists were highly concordant. We further show that the three representative baseline methods used to generate recommended articles for evaluation (Okapi Best Matching 25, Term Frequency–Inverse Document Frequency and PubMed Related Articles) had similar overall performances. Additionally, we found that these methods each tend to produce distinct collections of recommended articles, suggesting that a hybrid method may be required to completely capture all relevant articles. The established database server located at https://relishdb.ict.griffith.edu.au is freely available for the downloading of annotation data and the blind testing of new methods. We expect that this benchmark will be useful for stimulating the development of new powerful techniques for title and title/abstract-based search engines for relevant articles in biomedical research.
    Type of Medium: Online Resource
    ISSN: 1758-0463
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2019
    detail.hit.zdb_id: 2496706-3
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 3
    In: Foot & Ankle Orthopaedics, SAGE Publications, Vol. 7, No. 4 ( 2022-10), p. 2473011421S0058-
    Abstract: Hindfoot; Midfoot/Forefoot; Other Introduction/Purpose: Progressive collapsing foot deformity (PCFD) is a complex three-dimensional (3D) deformity characterized by peritalar subluxation (PTS) of the hindfoot through the triple joint complex. In this context, adjacent structures adopt different positions, and bone relations change, producing areas of higher or less contact and stress. The objective of this study was to use 3D distance maps (DMs) and coverage maps (CMs) from weightbearing CT (WBCT) images to assess subluxation across the Chopart joint in PCFD patients. We hypothesized that CMs would show decreased coverage indicative of subluxation through regions of the Chopart joint in PCFD patients when compared to controls. Methods: In this IRB-approved, retrospective case-control study, we analyzed WBCT data of 20 consecutive patients with flexible PCFD and 20 controls. Using principle component analysis, coverage area was divided into six regions on the talar head and 4 on the calcaneal-cuboid articular surface. Novel 3D distance mapping (DM) technique was used to objectively characterize joint coverage across the entire Chopart surface on both talus and calcaneus. Distance maps were measured in millimeters and colored to highlight covered areas. Distances less than 4mm were defined to be covered, while areas with distances greater than 4mm uncovered. Joint coverage was defined as percentage of articular area with DMs lower than 4 mm. Coverage Maps (CM) were built highlighting areas of coverage (teal) versus non-coverage (pink). The Foot and Ankle Offset (FAO) was used as a reference semi-automatic three-dimensional measurement. Comparisons were performed with independent t-tests, assuming unequal variances and p-values 〈 .05 considered significant. Results: Changes in coverage percentages of PCFD cases relative to controls are indicated in the attached figure. The superomedial and the inferomedial regions of the talar head were found to have a 75% and 79% decrease in coverage in PCFD cases relative to the controls (ps 〈 0.003). The medial side of the head had an overall increase in coverage (ps 〈 0.002). On the calcaneus, the calcaneal-cuboid joint plantar region was found to have a significant coverage decrease of 12% relative to the controls (p=0.037), while the lateral quadrant observed a 13% increase (p=0.002). DMs evaluation showed no significant differences in the mean distances for either the calcaneocuboid or the talonavicular (ps 〉 0.05). The FAO was found to be correlated with changes in talar and calcaneal coverages (rs=0.90; R2=0.81). Conclusion: Our results support the hypothesis that significant changes occur at the Chopart joint in early flexible PCFD cases. Increased coverage in the lateral region of the talar head and decreased coverage in the medial and plantar regions point to internal rotation of the talus indicating subluxation through the entire joint. This behavior was also translated in the calcaneal- cuboid, where plantar and medial areas had a decrease in coverage. Coverage 3D mapping enabled objective subluxation quantification through the Chopart joint in early-stage PCFD. These findings may assist clinical assessment of normal joint alignment restoration during PCFD corrections.
    Type of Medium: Online Resource
    ISSN: 2473-0114 , 2473-0114
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2874570-X
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 4
    In: Foot & Ankle Orthopaedics, SAGE Publications, Vol. 7, No. 4 ( 2022-10), p. 2473011421S0058-
    Abstract: Bunion; Midfoot/Forefoot Introduction/Purpose: Little is known about the intersesamoid crista in Hallux Valgus (HV). However, this structure directly interfaces with the sesamoids and surrounding soft tissues and might play an important role in HV deformity. Our primary objective was to compare the angulation between the crista and first metatarsal (M1) longitudinal axis in HV and controls. Our secondary objective was to assess its correlation with the Distal Metatarsal Articular Angle (DMAA). We hypothesized that the longitudinal axis of the crista will be deviated in valgus in HV and that its position will be correlated with the DMAA. Methods: This IRB approved retrospective case control study evaluated 9 HV and 8 controls matched on age, BMI, and gender. The DMAA was measured as initially described on X-Rays, and then on weight-bearing CT images using a previously validated technique including pronation correction of the M1 called 3d-DMAA. To identify the angle of the inter-sesamoid crista relative to the shaft of the 1st metatarsal, CT scans were semi-automatically segmented to create 3D models of the forefoot. The crista was selected in Geomagic Design X and the resulting STL models were imported into MATLAB for analysis. Principal component analysis was used to identify the direction of both the crista and the 1st metatarsal shaft. The crista-shaft angle is the angle between the directions of greatest variation. Normality was assessed using Shapiro-Wilk tests. Comparisons were made using Student T-tests for normal variables and Mann-Whitney for non-normals. Correlations were assessed using Pearson's coefficients. Results: The crista deviated from the 1st metatarsal shaft in valgus in all the cases (HV and controls). There was a significant increase in valgus deviation of the crista in HV compared to controls (respectively 14.4+/-8.7 degrees and 5.5+/-3.2 degrees; p=0.017). Mean DMAA were respectively 25.1+/-7.9 degrees in HV and 7.4+/-2.9 in controls (p 〈 0.001). Mean 3d-DMAA were respectively 12.5+/-5.6 degrees in HV and 3.1+/-2.4 in controls (p 〈 0.001). There was a low positive non-significant correlation between the crista deviation and the DMAA (ρ=0.44; r2=0.193; p=0.078). There was a moderate positive significant correlation between Crista M1 Angle and 3D-DMAA (ρ=0.57; r2=0.326; p=0.017). Conclusion: The longitudinal axis of the inter-sesamoid crista deviates from the 1st metatarsal shaft in valgus in HV compared to controls. This follows the pattern of the 3d-DMAA which reflect the valgus deviation of the articular surface after exclusion of the pronation which is an important confounding factor of the original DMAA. The inter-sesamoid crista may play a role in HV pathophysiology as a possible lateral destabilizer of the surrounding soft tissues in HV. Surgically correcting the DMAA with a distal osteotomy might also correct the crista position in HV.
    Type of Medium: Online Resource
    ISSN: 2473-0114 , 2473-0114
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2874570-X
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 5
    In: Foot & Ankle Orthopaedics, SAGE Publications, Vol. 7, No. 4 ( 2022-10), p. 2473011421S0060-
    Abstract: Midfoot/Forefoot; Other Introduction/Purpose: The etiology of hallux rigidus (HR) is not well understood and its association with first-ray hypermobility, hallux valgus and metatarsus primus elevatus (MPE) has not been clearly proven. Recent studies have supported MPE in HR by measuring on weightbearing radiographs (WBR), but there are limitations of WBR due to variation in X-ray projection and superimposed metatarsals. WBCT represent a reliable tool for radiographic analysis of the first ray and can be important for the study pathologies such as HR, which involve several anatomical points to be evaluated for a correct clinical- radiographic diagnosis Our objective was to evaluate radiographic parameters associated with Hallux Rigidus via WBR and WBCT for convergent validity and to evaluate the use of the classification system used in conventional radiography with WBCT. Methods: This is a single-center, retrospective study from prospectively collected data. 20 symptomatic hallux rigidus patient with weightbearing radiograph and WBCT were enrolled from October 2014 to December 2020. Measured parameters included hallux valgus angle (HVA), intermetatarsal angle (IMA), 1st TMT joint version, First and second metatarsal lengths, 2nd cuneiform- 2nd metatarsal angle, Talus-1st Metatarsal angle, First and second metatarsal declination angles, and MPE. MPE was measured as the direct distance between 1st and 2nd metatarsals (modified Horton index). All patients were graded according to the radiographic criteria of Coughlin and Shurnas classification on radiographs and WBCT, separately. Paired T-test was performed to compare radiographic measurements with WBCT. Results: Mean age was 55.9. HVA (15.73° in X-ray vs 14.04° in WBCT), AP first TMT version (16.25° vs 16.47°), 2nd cuneiform- 2nd metatarsal angle (24.54° vs 26.60°), Talus-1st Metatarsal Angle (-7.67° vs -7.89°) were not different between radiograph and WBCT. MPE was measured higher in WBCT by 0.86 mm compared to radiograph. First metatarsal declination angle was lower in WBCT by 2.9° indicating increased MPE. When graded with radiographic findings, 5 (25%) patients were grade 1, 5 (25%) patients were grade 2 and 10 (50%) grade 3, when graded with WBCT, 1 (5%) patient had grade 1, 3 (15%) patients were grade 2 and 16 (80%) grade 3. When graded radiologically, subchondral cyst in proximal phalanx and metatarsal head were better delineated resulting in higher radiographic grade with WBCT. Dorsal subluxation/translation of first metatarsal at first TMT joint was observed 3 (15%) in radiograph and 9 (45%) in WBCT. Conclusion: Hallux Valgus Angle, AP first TMT version, 2nd cuneiform-2nd metatarsal angle, Talus-1st Metatarsal Angel demonstrated consistent measurements in radiograph and WBCT. MPE was measured higher in WBCT when measured with direct distance (0.86 mm) between the first and second metatarsals using modified Horton index and first metatarsal declination angle (2.9°). When graded with WBCT, the subchondral cyst in the proximal phalanx and metatarsal head were better delineated leading to higher grade in WBCT which infer WBCT grading system for HR can aid in early detection of advanced HR with high radiographic grades and potentially guide treatment accordingly.
    Type of Medium: Online Resource
    ISSN: 2473-0114 , 2473-0114
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2874570-X
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 6
    In: Foot & Ankle Orthopaedics, SAGE Publications, Vol. 7, No. 4 ( 2022-10), p. 247301142211375-
    Abstract: Weightbearing computed tomography (WBCT) measurements allow evaluation of several anatomical points for a correct clinical-radiographic diagnosis of pathologies, such as hallux rigidus (HR). In addition, a new semiautomatic segmentation software obtains automated 3D measurements from WBCT scan data sets, minimizing errors in reading angular measurements. The study’s objective was (1) to evaluate the reliability of WBCT semiautomatic imaging measures in HR, (2) to evaluate correlation and agreement between manual and semiautomatic measures in the setting of HR, and (3) to compare semiautomatic measurements between pathologic (HR) and standard control groups. Methods: A retrospective study of HR patients was performed including 20 feet with HR. WBCT manual and semiautomatic 3D measurements were performed using the following parameters: (1) first metatarsal-proximal phalanx angle (1stMPP), (2) hallux valgus angle (HVA), (3) first to second intermetatarsal angle (IMA), (4) hallux interphalangeal angle (IPA), (5) first metatarsal length (1stML), (6) second metatarsal length (2ndML), (7) first metatarsal declination angle (1stMD), (8) second metatarsal declination angles (2ndMD), and (9) metatarsus primus elevatus (MPE). The differences between pathologic and control cases were assessed with a Wilcoxon test. Results: Interobserver and intraobserver agreement for manual vs semiautomatic WBCT measurements demonstrated excellent reliability. According to the Pearson coefficient, there was a strong positive linear correlation between both methods for the following parameters evaluated: HVA (ρ = 0.96), IMA (ρ = 0.86), IPA (ρ = 0.89), 1stML (ρ = 0.96), 2ndML (ρ = 0.91), 1stMD (ρ = 0.86), 2ndMD (ρ = 0.95), and MPE (ρ = 0.87). Comparison between the pathologic group with HR and the control (standard) group allowed for the differentiating of the pathologic (HR) from the non-pathologic conditions for MPE (p 〈 0.05). Conclusion: Semiautomatic measurements are reproducible and comparable to measurements performed manually, showing excellent interobserver and intraobserver agreement. The software used differentiated pathologic from nonpathologic conditions when submitted to semiautomatic MPE measurements. Level of Evidence: Level III, retrospective comparative study.
    Type of Medium: Online Resource
    ISSN: 2473-0114 , 2473-0114
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2874570-X
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 7
    In: Foot & Ankle Orthopaedics, SAGE Publications, Vol. 7, No. 4 ( 2022-10), p. 2473011421S0073-
    Abstract: Midfoot/Forefoot; Other Introduction/Purpose: Lateral Column Lengthening (LCL), Medial Displacement Calcaneal Osteotomy (MDCO) and Cotton Osteotomy (CO) are considered the work-horse surgical procedures for Progressive Collapsing Foot Deformity (PCFD) correction. The amount of three-dimensional correction induced by each isolated procedure cannot be established in the clinical setting since procedures are frequently performed in combination based on deformity severity and surgeon's preference. Understanding the influence of each one of the procedures, as well as their magnitudes, in the overall 3D correction of the deformity would be extremely helpful in the surgical planning of PCFD. Therefore, our simulated weightbearing cadaveric study aimed to assess the amount of 3D correction induced by different magnitudes of isolated and combined LCL, MDCO, and CO procedures, using weightbearing CT (WBCT) imaging. Methods: In this cadaveric study 12 below-knee specimens with no deformity were used. They were mounted on a frame under 360N of axial load, while keeping conventional stance level tension to tendinous structures. Each group of four specimens underwent isolated and progressive magnitudes of MDCO (6, 10 and 14mm), LCL (6, 8 and 10mm) and CO (4, 8 and 12mm). Following isolated correction, the specimens were randomized into different amounts of combined correction, first with two procedures (only moderate correction; four specimens each combination) and then with three procedures (combined mild, moderate and large corrections; four specimens each). The 3D measurement Foot and Ankle Offset (FAO), representing the relative position between the center of the ankle joint and the weight bearing tripod of the foot, was calculated from WBCT datasets for each specimen in each one of the tested corrected conditions. Comparison between the different conditions was performed using Paired T-Test/Wilcoxon. Results: All isolated performed corrective procedures (MDCO, LCL and CO) significantly influenced FAO measurements (All p- values 〈 0.05). When applied in isolation, every 1mm increase in MDCO, LCL and CO decreased FAO values by respectively 0.8%, 0.36%, and 0.29%, highlighting the importance of the heel position in the overall 3D position of the foot. Combination of two moderate-sized procedures decreased FAO values significantly (p 〈 0.05) and more pronouncedly, with combination of MDCO and LCL decreasing FAO by an average of 7.2%, MDCO and CO by 6.2% and LCL and CO by 3.9%, with no significant differences between the three. As expected, combination of the three procedures lead to pronounced and significant decreased of FAO values by respectively 5.2%, 8.5% and 14.2% for mild, moderate, and large corrections. The combination of the three large sized corrections was significantly higher than mild and moderate corrections (p=0.002). Conclusion: In this cadaveric WBCT study we assessed the influence of different magnitudes of isolated and combined MDCO, LCL and CO in foot and ankle 3D alignment. We found that all isolated procedures significantly decreased FAO measurements, with every 1mm increase in MDCO, LCL and CO decreasing FAO by respectively 0.8%, 0.36%, and 0.29%. Combination of two procedures and three procedures also lead to significant and more pronounced alignment change. The data presented in this study can serve as baseline predictive values of foot alignment correction when planning the use of MDCO, LCL and CO for surgical treatment of PCFD.
    Type of Medium: Online Resource
    ISSN: 2473-0114 , 2473-0114
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2874570-X
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 8
    In: Nature, Springer Science and Business Media LLC, Vol. 518, No. 7538 ( 2015-02-12), p. 187-196
    Type of Medium: Online Resource
    ISSN: 0028-0836 , 1476-4687
    RVK:
    RVK:
    RVK:
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2015
    detail.hit.zdb_id: 120714-3
    detail.hit.zdb_id: 1413423-8
    SSG: 11
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 9
    In: Foot & Ankle Orthopaedics, SAGE Publications, Vol. 7, No. 1 ( 2022-01)
    Abstract: Hindfoot; Midfoot/Forefoot Introduction/Purpose: The same Consensus that proposed a new nomenclature for Flatfoot, Progressive Collapsing Foot Deformity (PCFD), also introduced a new classification system for the disease. The idea of staging was supplemented by the construction of a system combining deformity classes and its flexibilities, using clinical and radiographic signs. The capacity of the weight-bearing computed tomography (WBCT) in evaluating PCFD and all components of peritalar subluxation has been established. The objective of this study was to compare PCFD classifications performed utilizing clinical and conventional radiographs (CR) findings with classifications established using clinical and WBCT findings. We hypothesized that evaluations considering WBCT would significantly change PCFD classifications, portraying a different picture of the disease. Methods: This retrospective IRB-approved case-control diagnostic study evaluated 89 consecutive PCFD feet (84 patients) with different presentations of the disease. Three fellowship-trained foot and ankle surgeons performed chart reviews and CR evaluations, determining PCFD classifications for the studied subjects. After a two-week washout period, the sequence was randomized, and a new classification was executed using clinical data and WBCT assessment. One of the readers repeated the WBCT evaluation two weeks later for intrarater reliability purposes. Assessments included presence or absence of classes, such as hindfoot valgus (A), midfoot abduction/sinus tarsi impingement (B), medial column instability (C), subtalar joint subluxation/subfibular impingement (D) and valgus of the ankle joint (E) as well as flexibility (1) and rigidity (2) of existing deformities. Fleiss kappa was used for interrater and Cohen's kappa for intrarater agreements. Differences between studied groups were determined by distribution comparison. Results: Mean BMI and age were 54.4 (+-17.1) and 33.6 (+-7.6) respectively. Interrater reliability was found to be moderate (0.55) and intrarater to be excellent (0.98). Evaluation using CR produced 22.8% of 1ABC, 13% of 1AC, 8,7% of 1ABCD and 7% of 2EABCD as most prevalent classifications. WBCT assessment found 31.5% of 1ABC, 11.2% of 1ABCD, 10.1% of 2ABCDE and 5.6% 1ABCDE. Class A was the most frequent component in CR (93.5%) and WBCT (94.5%). Class B had a higher prevalence in WBCT (94.38%) than in CR (71.7%) as well as Classes C (89.9% and 88.0%), D (44.9% and 29.3%) and E (31.5% and 23.9%). The percentage of combined flexible (1) and rigid (2) deformities was also higher in the WBCT evaluation (39.3% compared to 35.8%). Conclusion: As the new classification proposes the combination of different PCFD components to better support clinical decisions, proper identification of the classes is mandatory for a complete diagnosis. WBCT showed a different rate of deformity recognition, which increased the incidence of all classes, especially B (midfoot abduction/sinus tarsi impingement) and D (peritalar subluxation/subfibular impingement). An excellent intrarater agreement was found, which infers reliability of patient assessment combining clinical and WBCT evaluation. The obtained information could help providers to enhance comprehension of the disease and to supply patients with the most precise individual care.
    Type of Medium: Online Resource
    ISSN: 2473-0114 , 2473-0114
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2874570-X
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 10
    In: Foot & Ankle Orthopaedics, SAGE Publications, Vol. 7, No. 1 ( 2022-01)
    Abstract: Midfoot/Forefoot Introduction/Purpose: The etiology of hallux rigidus (HR) is not well understood and Its association with first-ray hypermobility, hallux valgus and metatarsus primus elevatus (MPE) has not been clearly proven. MPE, elevated first metatarsal has been a topic of debate since Lambrinudi`s first description. Recent studies have supported MPE in hallux rigidus by measuring with various methods on wightbearing lateral radiographs, but there are limitations of conventional radiography due to variation in X- ray projection and superimposed metatarsals regardless of the methods of measurement. Our objective was to assess MPE and other associated parameters with hallux rigidus via radiography and WBCT for convergent validity and to evaluate the use of classification system used in conventional radiography with WBCT. Methods: This is a single-center, retrospective study from prospectively collected data. 20 symptomatic hallux rigidus patient with weightbearing radiograph and WBCT were enrolled from October 2014 to December 2020. Measured parameters included hallux valgus angle (HVA), intermetatarsal angle (IMA), hallux interphalangeal angle (HIPA), distal metatarsal articular angle (DMAA), 1st TMT joint version, First and second metatarsal lengths, Metatarsus adductus angle, 2nd cuneiform-2nd metatarsal angle, Talus-1st Metatarsal Angel, First and second metatarsal declination angles, and MPE. MPE was measured as the direct distance between 1st and 2nd metatarsals (modified Horton index). All patients were graded according to the radiographic criteria of Coughlin and Shurnas classification on radiographs and WBCT, separately. Paired T-test was performed to compare radiographic measurements with WBCT. Results: Mean age was 55.9, 12 males and 8 females. HVA (15.73 in X-ray vs 14.04 in WBCT), AP first TMT version (16.25 vs 16.47), 2nd cuneiform-2nd metatarsal angle (24.54 vs 26.60), Talus-1st Metatarsal Angel (-7.67 vs -7.89) were not different between radiograph and WBCT. MPE was measured higher in WBCT by 0.86 mm compared to radiograph. First metatarsal declination angle was lower in WBCT by 2.9° indicating increased MPE. When graded with radiographic findings, 5 (25%) patients were grade 1, 5 (25%) patients were grade 2 and 10 (50%) grade 3, when graded with WBCT, 1 (5%) patient had grade 1, 3 (15%) patients were grade 2 and 16 (80%) grade 3. Dorsal subluxation/translation of first metatarsal at first TMT joint was observed 3 (15%) in radiograph and 9 (45%) in WBCT. Conclusion: HVA, AP first TMT version, 2nd cuneiform-2nd metatarsal angle, Talus-1st Metatarsal Angel demonstrated consistent measurements in radiograph and WBCT. MPE was measured higher in WBCT when measured with direct distance (0.86 mm) between the first and second metatarsals using modified Horton index and first metatarsal declination angle (2.9°). When graded with WBCT, the subchondral cyst in the proximal phalanx and metatarsal head were better delineated leading to higher grade in WBCT. Further studies are needed for inter-rater reliability and discriminant validity of the measurements determined by differences between different groups (HR vs control).
    Type of Medium: Online Resource
    ISSN: 2473-0114 , 2473-0114
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2874570-X
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. Further information can be found on the KOBV privacy pages