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Randomized Trial of Adjunctive Interleukin-2 in Adults with Pulmonary Tuberculosis

Johnson, John L. ; Ssekasanvu, Emmanuel ; Okwera, Alphonse ; [weitere]

American Thoracic Society ; 2003

In: American Journal of Respiratory and Critical Care Medicine Vol. 168, No. 2 ( 2003-07-15), p. 185-191

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In: American Journal of Respiratory and Critical Care Medicine, American Thoracic Society, Vol. 168, No. 2 ( 2003-07-15), p. 185-191

Materialart: Online-Ressource

ISSN: 1073-449X , 1535-4970

URL: Article

DOI: 10.1164/rccm.200211-1359OC

RVK:

XA 21200

Sprache: Englisch

Verlag: American Thoracic Society

Publikationsdatum: 2003

ZDB Id: 1468352-0

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Exochelin genes in Mycobacterium smegmatis : identification of an ABC transporter and two non‐ribosomal peptide synthetase genes

Zhu, Wenming ; Arceneaux, Jean E. L. ; Beggs, Marjorie L. ; [weitere]

Wiley ; 1998

In: Molecular Microbiology Vol. 29, No. 2 ( 1998-07), p. 629-639

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In: Molecular Microbiology, Wiley, Vol. 29, No. 2 ( 1998-07), p. 629-639

Kurzfassung: Many strains of mycobacteria produce two ferric chelating substances that are termed exochelin (an excreted product) and mycobactin (a cell‐associated product). These agents may function as iron acquisition siderophores. To examine the genetics of the iron acquisition system in mycobacteria, ultraviolet (UV) and transposon (Tn 611 ) mutagenesis techniques were used to generate exochelin‐deficient mutants of Mycobacterium smegmatis strains ATCC 607 and LR222 respectively. Mutants were identified on CAS siderophore detection agar plates. Comparisons of the amounts of CAS‐reactive material excreted by the possible mutant strains with that of the wild‐type strains verified that seven UV mutant strains and two confirmed transposition mutant strains were deficient in exochelin production. Cell‐associated mycobactin production in the mutants appeared to be normal. From the two transposon mutants, the mutated gene regions were cloned and identified by colony hybridization with an IS 6100 probe, and the DNA regions flanking the transposon insertion sites were then used as probes to clone the wild‐type loci from M. smegmatis LR222 genomic DNA. Complementation assays showed that an 8 kb Pst I fragment and a 4.8 kb Pst I/ Sac I subclone of this fragment complemented one transposon mutant (LUN2) and one UV mutant (R92). A 10.1 kb Sac I fragment restored exochelin production to the other transposon mutant (LUN1). The nucleotide sequence of the 15.3 kb DNA region that spanned the two transposon insertion sites overlapped the 5′ region of the previously reported exochelin biosynthetic gene fxbA and contained three open reading frames that were transcribed in the opposite orientation to fxbA . The corresponding genes were designated exiT , fxbB and fxbC . The deduced amino acid sequence of ExiT suggested that it was a member of the ABC transporter superfamily, while FxbB and FxbC displayed significant homology with many enzymes (including pristinamycin I synthetase) that catalyse non‐ribosomal peptide synthesis. We propose that the peptide backbone of the siderophore exochelin is synthesized in part by enzymes resembling non‐ribosomal peptide synthetases and that the ABC transporter ExiT is responsible for exochelin excretion.

Materialart: Online-Ressource

ISSN: 0950-382X , 1365-2958

URL: Article

DOI: 10.1046/j.1365-2958.1998.00961.x

Sprache: Englisch

Verlag: Wiley

Publikationsdatum: 1998

ZDB Id: 1501537-3

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Rate and Amplification of Drug Resistance among Previously‐Treated Patients with Tuberculosis in Kampala, Uganda

Temple, Beth ; Ayakaka, Irene ; Ogwang, Sam ; [weitere]

Oxford University Press (OUP) ; 2008

In: Clinical Infectious Diseases Vol. 47, No. 9 ( 2008-11), p. 1126-1134

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In: Clinical Infectious Diseases, Oxford University Press (OUP), Vol. 47, No. 9 ( 2008-11), p. 1126-1134

Materialart: Online-Ressource

ISSN: 1058-4838 , 1537-6591

URL: Issue

URL: Article

DOI: 10.1086/594992

DOI: 10.1086/592252

RVK:

XA 10000

Sprache: Englisch

Verlag: Oxford University Press (OUP)

Publikationsdatum: 2008

ZDB Id: 2002229-3

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Prospective Evaluation of the Utility of Molecular Techniques for Diagnosing Nosocomial Transmission of Multidrug-Resistant Tuberculosis

Cockerill, Franklin R. ; Williams, David E. ; Eisenach, Kathleen D. ; [weitere]

Elsevier BV ; 1996

In: Mayo Clinic Proceedings Vol. 71, No. 3 ( 1996-3), p. 221-229

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In: Mayo Clinic Proceedings, Elsevier BV, Vol. 71, No. 3 ( 1996-3), p. 221-229

Materialart: Online-Ressource

ISSN: 0025-6196

URL: Article

DOI: 10.4065/71.3.221

RVK:

XA 10000

Sprache: Englisch

Verlag: Elsevier BV

Publikationsdatum: 1996

ZDB Id: 2052617-9

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Effectiveness of the Standard WHO Recommended Retreatment Regimen (Category II) for Tuberculosis in Kampala, Uganda: A Prospective Cohort Study

Jones-López, Edward C. ; Ayakaka, Irene ; Levin, Jonathan ; [weitere]

Public Library of Science (PLoS) ; 2011

In: PLoS Medicine Vol. 8, No. 3 ( 2011-3-15), p. e1000427-

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In: PLoS Medicine, Public Library of Science (PLoS), Vol. 8, No. 3 ( 2011-3-15), p. e1000427-

Materialart: Online-Ressource

ISSN: 1549-1676

URL: Article

DOI: 10.1371/journal.pmed.1000427

DOI: 10.1371/journal.pmed.1000427.g001

DOI: 10.1371/journal.pmed.1000427.g002

DOI: 10.1371/journal.pmed.1000427.t001

DOI: 10.1371/journal.pmed.1000427.t002

DOI: 10.1371/journal.pmed.1000427.t003

DOI: 10.1371/journal.pmed.1000427.s001

DOI: 10.1371/journal.pmed.1000427.s002

Sprache: Englisch

Verlag: Public Library of Science (PLoS)

Publikationsdatum: 2011

ZDB Id: 2164823-2

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Elucidating Emergence and Transmission of Multidrug-Resistant Tuberculosis in Treatment Experienced Patients by Whole Genome Sequencing

Clark, Taane G. ; Mallard, Kim ; Coll, Francesc ; [weitere]

Public Library of Science (PLoS) ; 2013

In: PLoS ONE Vol. 8, No. 12 ( 2013-12-11), p. e83012-

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In: PLoS ONE, Public Library of Science (PLoS), Vol. 8, No. 12 ( 2013-12-11), p. e83012-

Materialart: Online-Ressource

ISSN: 1932-6203

URL: Article

DOI: 10.1371/journal.pone.0083012

DOI: 10.1371/journal.pone.0083012.g001

DOI: 10.1371/journal.pone.0083012.g002

DOI: 10.1371/journal.pone.0083012.g003

DOI: 10.1371/journal.pone.0083012.t001

DOI: 10.1371/journal.pone.0083012.t002

DOI: 10.1371/journal.pone.0083012.t003

DOI: 10.1371/journal.pone.0083012.t004

DOI: 10.1371/journal.pone.0083012.t005

DOI: 10.1371/journal.pone.0083012.s001

DOI: 10.1371/journal.pone.0083012.s002

DOI: 10.1371/journal.pone.0083012.s003

DOI: 10.1371/journal.pone.0083012.s004

DOI: 10.1371/journal.pone.0083012.s005

DOI: 10.1371/journal.pone.0083012.s006

DOI: 10.1371/journal.pone.0083012.s007

DOI: 10.1371/journal.pone.0083012.s008

Sprache: Englisch

Verlag: Public Library of Science (PLoS)

Publikationsdatum: 2013

ZDB Id: 2267670-3

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Microaerophilic Induction of the Alpha-Crystallin Chaperone Protein Homologue ( hspX ) mRNA of Mycobacterium tuberculosis

DesJardin, Lucy E. ; Hayes, LaDonna G. ; Sohaskey, Charles D. ; [weitere]

American Society for Microbiology ; 2001

In: Journal of Bacteriology Vol. 183, No. 18 ( 2001-09-15), p. 5311-5316

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In: Journal of Bacteriology, American Society for Microbiology, Vol. 183, No. 18 ( 2001-09-15), p. 5311-5316

Kurzfassung: Among the products that are expressed when Mycobacterium tuberculosis undergoes hypoxic shiftdown to nonreplicating persistence (NRP) is the alpha-crystallin chaperone protein homologue (Acr). This expression coincides with the previously reported appearance of a respiratory type of nitrate reductase activity, the increase in glycine dehydrogenase activity, and the production of a unique antigen, URB-1. In a timed sampling study, using a slowly stirred oxygen depletion culture model, we have demonstrated that the hspX mRNA that codes for Acr protein as well as the protein itself is induced just as the bacilli enter the microaerophilic NRP stage 1 (NRP-1). In contrast to the induction observed for hspX mRNA, levels of 16S rRNA, fbpB mRNA (encoding the 85B alpha antigen), and aroB mRNA (encoding dehydroquinate synthase) demonstrate relatively small to no change upon entering NRP-1. Acr protein was shown to be identical to URB-1 by Western analysis with anti-URB-1 antibody. The fact that antibody to Acr is found in a high percentage of tuberculosis patients suggests that the hypoxic shiftdown of tubercle bacilli to the NRP state that occurs in vitro, resulting in production of the alpha-crystallin protein, occurs in vivo as well. Simultaneous abrupt increases in hspX mRNA and Acr protein suggest that Acr protein expression is controlled at the level of transcription.

Materialart: Online-Ressource

ISSN: 0021-9193 , 1098-5530

URL: Article

DOI: 10.1128/JB.183.18.5311-5316.2001

Sprache: Englisch

Verlag: American Society for Microbiology

Publikationsdatum: 2001

ZDB Id: 1481988-0

SSG: 12

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Shortening Treatment in Adults with Noncavitary Tuberculosis and 2-Month Culture Conversion

Johnson, John L. ; Hadad, David Jamil ; Dietze, Reynaldo ; [weitere]

American Thoracic Society ; 2009

In: American Journal of Respiratory and Critical Care Medicine Vol. 180, No. 6 ( 2009-09-15), p. 558-563

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In: American Journal of Respiratory and Critical Care Medicine, American Thoracic Society, Vol. 180, No. 6 ( 2009-09-15), p. 558-563

Materialart: Online-Ressource

ISSN: 1073-449X , 1535-4970

URL: Article

DOI: 10.1164/rccm.200904-0536OC

RVK:

XA 21200

Sprache: Englisch

Verlag: American Thoracic Society

Publikationsdatum: 2009

ZDB Id: 1468352-0

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Detection of Mycobacterium tuberculosis in Sputum Samples Using a Polymerase Chain Reaction

Eisenach, Kathleen D. ; Sifford, Mark D. ; Cave, M. Donald ; [weitere]

American Thoracic Society ; 1991

In: American Review of Respiratory Disease Vol. 144, No. 5 ( 1991-11), p. 1160-1163

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In: American Review of Respiratory Disease, American Thoracic Society, Vol. 144, No. 5 ( 1991-11), p. 1160-1163

Materialart: Online-Ressource

ISSN: 0003-0805

URL: Article

DOI: 10.1164/ajrccm/144.5.1160

RVK:

XA 21200

Sprache: Englisch

Verlag: American Thoracic Society

Publikationsdatum: 1991

ZDB Id: 1468352-0

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Treatment Outcomes of New Tuberculosis Patients Hospitalized in Kampala, Uganda: A Prospective Cohort Study

Kirenga, Bruce J. ; Levin, Jonathan ; Ayakaka, Irene ; [weitere]

Public Library of Science (PLoS) ; 2014

In: PLoS ONE Vol. 9, No. 3 ( 2014-3-7), p. e90614-

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In: PLoS ONE, Public Library of Science (PLoS), Vol. 9, No. 3 ( 2014-3-7), p. e90614-

Materialart: Online-Ressource

ISSN: 1932-6203

URL: Article

DOI: 10.1371/journal.pone.0090614

DOI: 10.1371/journal.pone.0090614.g001

DOI: 10.1371/journal.pone.0090614.g002

DOI: 10.1371/journal.pone.0090614.g003

DOI: 10.1371/journal.pone.0090614.t001

DOI: 10.1371/journal.pone.0090614.t002

DOI: 10.1371/journal.pone.0090614.t003

DOI: 10.1371/journal.pone.0090614.t004

DOI: 10.1371/journal.pone.0090614.t005

Sprache: Englisch

Verlag: Public Library of Science (PLoS)

Publikationsdatum: 2014

ZDB Id: 2267670-3

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