In:
Circulation, Ovid Technologies (Wolters Kluwer Health), Vol. 94, No. 6 ( 1996-09-15), p. 1339-1345
Abstract:
Background The effects of cardiac transplantation on cognitive brain function are uncertain. Methods and Results We measured cognitive brain function and quality of life in out-of-hospital cardiac transplant candidates (n=55; ejection fraction, 19.9%; age, 54.8 years [means]). After transplantation, the patients were serially reevaluated at 4 months (n=25) and at 12 months (n=19). Brain function was measured objectively by cognitive P300 evoked potentials. Additionally, standard psychometric tests (Trail Making Test A, Mini-Mental State Examination, and Profile of Mood State test) were performed. Cognitive P300 evoked potentials were impaired in cardiac transplant candidates (359 ms, recorded at vertex) compared with 55 age- and sex-matched healthy subjects (345 ms, P 〈 .01). Trail Making Test A was also abnormal (45 versus 31 seconds in 55 healthy subjects, P 〈 .01). After transplantation, P300 measures were normalized at 4 months (345 ms, P 〈 .05 versus before transplantation) but declined again at 12 months (352 ms, P =NS versus before transplantation). Stepwise multiple regression analysis revealed that cumulative cyclosporine dosage was the only predictor of individual cognitive brain function 4 months (753 mg/kg body wt, P 〈 .05) and 12 months (2006 mg/kg body wt, P 〈 .01) after transplantation, respectively. Conclusions Objective cognitive P300 auditory evoked potential measurements indicate that cognitive brain function is significantly impaired in patients suffering from stable end-stage heart failure. Successful cardiac transplantation is effective to fully normalize impaired brain function. Subsequent relative long-term decline of cognitive brain function after successful cardiac transplantation is strongly suggested to be related to cumulative cyclosporine neurotoxicity.
Type of Medium:
Online Resource
ISSN:
0009-7322
,
1524-4539
DOI:
10.1161/01.CIR.94.6.1339
Language:
English
Publisher:
Ovid Technologies (Wolters Kluwer Health)
Publication Date:
1996
detail.hit.zdb_id:
1466401-X
Bookmarklink