In:
Dubai Medical Journal, S. Karger AG, Vol. 4, No. 2 ( 2021-4-14), p. 142-150
Abstract:
〈 b 〉 〈 i 〉 Introduction: 〈 /i 〉 〈 /b 〉 COVID-19 has caused approximately one million deaths worldwide as of November 24, 2020. Markers of disease activity like ferritin, C-reactive protein (CRP), and D-dimers are frequently monitored to detect the best opportunity for intensive treatment. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 All patients of & #x3e;18 years of age were included. The primary variables of interest, ferritin, CRP, and D-dimers, for each patient throughout hospitalization were recorded. Primary clinical outcomes of length of stay in ICU and survival were recorded. 〈 b 〉 〈 i 〉 Demographics: 〈 /i 〉 〈 /b 〉 age, gender, BMI, and nationality. Ferritin, CRP, and D-dimers were recorded daily if available for the whole ICU stay, and all other variables were recorded on admission day to ICU. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 The sample includes 235 records. More than 95% of patients have all markers on the day of admission to ICU were ferritin (median 1,278; IQR 1,424), D-dimer 1.21 (3.4), and CRP 129.5 (121). Daily average levels of markers were different from their admission day level: ferritin 1,395 (1,331), D-dimer 3.11 (5.52), and CRP 107 (75.8). Multiple logistic regression analysis determined that average CRP during the stay was the only predictor of survival. 〈 b 〉 〈 i 〉 Discussion: 〈 /i 〉 〈 /b 〉 Data on markers utilization to detect the acute phase of inflammation help clinicians focus on the opportunity window for intensive treatment. 〈 b 〉 〈 i 〉 Conclusion: 〈 /i 〉 〈 /b 〉 Average CRP during the stay in ICU is higher than CRP on admission. Average CRP is the only factor that predicts survival.
Type of Medium:
Online Resource
ISSN:
2571-726X
Language:
English
Publisher:
S. Karger AG
Publication Date:
2021
detail.hit.zdb_id:
2938789-9
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