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The use of triclosan eluting stents effectively reduces ureteral stent symptoms: a prospective randomized trial : TRICLOSAN REDUCES URETERAL STENT SYMPTOMS

Mendez-Probst, Carlos E. ; Goneau, Lee W. ; MacDonald, Kyle W. ; [et al.]

Wiley ; 2012

In: BJU International Vol. 110, No. 5 ( 2012-09), p. 749-754

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In: BJU International, Wiley, Vol. 110, No. 5 ( 2012-09), p. 749-754

Type of Medium: Online Resource

ISSN: 1464-4096

URL: Issue

URL: Article

DOI: 10.1111/bju.2012.110.issue-5

DOI: 10.1111/j.1464-410X.2011.10903.x

Language: English

Publisher: Wiley

Publication Date: 2012

detail.hit.zdb_id: 2019983-1

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64: Triclosan Decreases Uropathogenic Escherichia Coli Adherence to Bladder Epithelial Cells

Elwood, Chelsea N. ; Mifflin, Shannon ; Cadieux, Peter A. ; [et al.]

Ovid Technologies (Wolters Kluwer Health) ; 2006

In: Journal of Urology Vol. 175, No. 4S ( 2006-04), p. 22-22

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In: Journal of Urology, Ovid Technologies (Wolters Kluwer Health), Vol. 175, No. 4S ( 2006-04), p. 22-22

Type of Medium: Online Resource

ISSN: 0022-5347 , 1527-3792

URL: Article

DOI: 10.1016/S0022-5347(18)32331-0

RVK:

XA 10000

Language: English

Publisher: Ovid Technologies (Wolters Kluwer Health)

Publication Date: 2006

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Table_2.pdf

Dos Santos, Scott J. ; Pakzad, Zahra ; Albert, Arianne Y. K. ; [et al.]

Frontiers Media SA ; 2023

In: Frontiers in Cellular and Infection Microbiology Vol. 13 ( 2023-3-30)

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In: Frontiers in Cellular and Infection Microbiology, Frontiers Media SA, Vol. 13 ( 2023-3-30)

Abstract: Birth mode has been implicated as a major factor influencing neonatal gut microbiome development, and it has been assumed that lack of exposure to the maternal vaginal microbiome is responsible for gut dysbiosis among caesarean-delivered infants. Consequently, practices to correct dysbiotic gut microbiomes, such as vaginal seeding, have arisen while the effect of the maternal vaginal microbiome on that of the infant gut remains unknown. We conducted a longitudinal, prospective cohort study of 621 Canadian pregnant women and their newborn infants and collected pre-delivery maternal vaginal swabs and infant stool samples at 10-days and 3-months of life. Using cpn 60-based amplicon sequencing, we defined vaginal and stool microbiome profiles and evaluated the effect of maternal vaginal microbiome composition and various clinical variables on the development of the infant stool microbiome. Infant stool microbiomes showed significant differences in composition by delivery mode at 10-days postpartum; however, this effect could not be explained by maternal vaginal microbiome composition and was vastly reduced by 3 months. Vaginal microbiome clusters were distributed across infant stool clusters in proportion to their frequency in the overall maternal population, indicating independence of the two communities. Intrapartum antibiotic administration was identified as a confounder of infant stool microbiome differences and was associated with lower abundances of Escherichia coli , Bacteroides vulgatus , Bifidobacterium longum and Parabacteroides distasonis . Our findings demonstrate that maternal vaginal microbiome composition at delivery does not affect infant stool microbiome composition and development, suggesting that practices to amend infant stool microbiome composition focus factors other than maternal vaginal microbes.

Type of Medium: Online Resource

ISSN: 2235-2988

URL: Article

DOI: 10.3389/fcimb.2023.1144254

DOI: 10.3389/fcimb.2023.1144254.s001

DOI: 10.3389/fcimb.2023.1144254.s002

DOI: 10.3389/fcimb.2023.1144254.s003

DOI: 10.3389/fcimb.2023.1144254.s004

DOI: 10.3389/fcimb.2023.1144254.s005

DOI: 10.3389/fcimb.2023.1144254.s006

DOI: 10.3389/fcimb.2023.1144254.s007

DOI: 10.3389/fcimb.2023.1144254.s008

DOI: 10.3389/fcimb.2023.1144254.s009

DOI: 10.3389/fcimb.2023.1144254.s010

DOI: 10.3389/fcimb.2023.1144254.s011

DOI: 10.3389/fcimb.2023.1144254.s012

DOI: 10.3389/fcimb.2023.1144254.s013

DOI: 10.3389/fcimb.2023.1144254.s014

Language: Unknown

Publisher: Frontiers Media SA

Publication Date: 2023

detail.hit.zdb_id: 2619676-1

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Use of Triclosan-Eluting Ureteral Stents in Patients with Long-Term Stents

Cadieux, Peter A. ; Chew, Ben H. ; Nott, Linda ; [et al.]

Mary Ann Liebert Inc ; 2009

In: Journal of Endourology Vol. 23, No. 7 ( 2009-07), p. 1187-1194

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In: Journal of Endourology, Mary Ann Liebert Inc, Vol. 23, No. 7 ( 2009-07), p. 1187-1194

Type of Medium: Online Resource

ISSN: 0892-7790 , 1557-900X

URL: Article

DOI: 10.1089/end.2008.0437

Language: English

Publisher: Mary Ann Liebert Inc

Publication Date: 2009

detail.hit.zdb_id: 2030846-2

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Early Neonatal Meconium Does Not Have a Demonstrable Microbiota Determined through Use of Robust Negative Controls with cpn 60-Based Microbiome Profiling

Dos Santos, Scott J. ; Pakzad, Zahra ; Elwood, Chelsea N. ; [et al.]

American Society for Microbiology ; 2021

In: Microbiology Spectrum Vol. 9, No. 2 ( 2021-10-31)

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In: Microbiology Spectrum, American Society for Microbiology, Vol. 9, No. 2 ( 2021-10-31)

Abstract: Detection of bacterial DNA within meconium is often cited as evidence supporting in utero colonization. However, many studies fail to adequately control for contamination. We aimed to define the microbial content of meconium under properly controlled conditions. DNA was extracted from 141 meconium samples and subjected to cpn 60-based microbiome profiling, with controls to assess contamination throughout. Total bacterial loads of neonatal meconium, infant stool, and controls were compared by 16S rRNA quantitative PCR (qPCR). Viable bacteria within meconium were cultured, and isolate clonality was assessed by pulsed-field gel electrophoresis (PFGE). Meconium samples did not differ significantly from controls with respect to read numbers or taxonomic composition. Twenty (14%) outliers with markedly higher read numbers were collected significantly later after birth and appeared more like transitional stool than meconium. Total bacterial loads were significantly higher in stool than in meconium, which did not differ from that of sequencing controls, and correlated well with read numbers. Cultured isolates were most frequently identified as Staphylococcus epidermidis , Enterococcus faecalis , or Escherichia coli , with PFGE indicating high intraspecies diversity. Our findings highlight the importance of robust controls in studies of low microbial biomass samples and argue against meaningful bacterial colonization in utero . Given that meconium microbiome profiles could not be distinguished from sequencing controls, and that viable bacteria within meconium appeared uncommon and largely consistent with postnatal skin colonization, there does not appear to be a meconium microbiota. IMPORTANCE Much like the recent placental microbiome controversy, studies of neonatal meconium reporting bacterial communities within the fetal and neonatal gut imply that microbial colonization begins prior to birth. However, recent work has shown that placental microbiomes almost exclusively represent contamination from lab reagents and the environment. Here, we demonstrate that prior studies of neonatal meconium are impacted by the same issue, showing that the microbial content of meconium does not differ from negative controls that have never contained any biological material. Our culture findings similarly supported this notion and largely comprised bacteria normally associated with healthy skin. Overall, our work adds to the growing body of evidence against the in utero colonization hypothesis.

Type of Medium: Online Resource

ISSN: 2165-0497

URL: Article

DOI: 10.1128/Spectrum.00067-21

Language: English

Publisher: American Society for Microbiology

Publication Date: 2021

detail.hit.zdb_id: 2807133-5

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Birth Mode Does Not Determine the Presence of Shared Bacterial Strains between the Maternal Vaginal Microbiome and the Infant Stool Microbiome

Dos Santos, Scott J. ; Shukla, Ishika ; Hill, Janet E. ; [et al.]

American Society for Microbiology ; 2023

In: Microbiology Spectrum Vol. 11, No. 4 ( 2023-08-17)

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In: Microbiology Spectrum, American Society for Microbiology, Vol. 11, No. 4 ( 2023-08-17)

Abstract: Dysbiosis of the neonatal gut microbiome during early life has been suggested as the missing link that may explain higher rates of certain diseases in caesarean section-delivered infants. Many studies report delivery mode-related dysbiosis in infants due to a lack of maternal vaginal microbiome exposure, prompting interventions to correct the neonatal gut microbiome by transferring these missing microbes after caesarean delivery. The maternal vaginal microbiome is among the first microbial exposures that many infants experience, yet little is known about the extent of direct transmission of maternal vaginal microbes. As part of the Maternal Microbiome Legacy Project, we aimed to determine if maternal vaginal bacteria are vertically transmitted to infants. We employed cpn 60 microbiome profiling, culture-based screening, molecular strain typing, and whole-genome sequencing to determine whether identical maternal vaginal strains were present in infant stool microbiomes. We identified identical cpn 60 sequence variants in both halves of maternal-infant dyads in 204 of 585 Canadian women and their newborn infants (38.9%). The same species of Bifidobacterium and Enterococcus were cultured from maternal and corresponding infant samples in 33 and 13 of these mother-infant dyads, respectively. Pulsed-field gel electrophoresis and whole-genome sequencing determined that near-identical strains were detected in these dyads irrespective of delivery mode, indicating an alternative source in cases of caesarean delivery. Overall, we demonstrated that vertical transmission of maternal vaginal microbiota is likely limited and that transmission from other maternal body sites, such as the gut and breast milk, may compensate for the lack of maternal vaginal microbiome exposure during caesarean delivery. IMPORTANCE The importance of the gut microbiome in human health and disease is widely recognized, and there has been a growing appreciation that alterations in gut microbiome composition during a “critical window” of development may impact health in later life. Attempts to correct gut microbiome dysbiosis related to birth mode are underpinned by the assumption that the lack of exposure to maternal vaginal microbes during caesarean delivery is responsible for dysbiosis. Here, we demonstrate that there is limited transmission of the maternal vaginal microbiome to the neonatal gut, even in cases of vaginal delivery. Furthermore, the presence of identical strains shared between mothers and infants in early life, even in cases of caesarean delivery, highlights compensatory microbial exposures and sources for the neonatal stool microbiome other than the maternal vagina.

Type of Medium: Online Resource

ISSN: 2165-0497

URL: Article

DOI: 10.1128/spectrum.00614-23

Language: English

Publisher: American Society for Microbiology

Publication Date: 2023

detail.hit.zdb_id: 2807133-5

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1446 IDENTIFICATION OF CONDITIONING FILM COMPONENTS ON INDWELLING URETERAL STENTS AND THEIR ROLE IN BACTERIAL ADHESION

Lange, Dirk ; Elwood, Chelsea N. ; Crowe, Adam ; [et al.]

Ovid Technologies (Wolters Kluwer Health) ; 2010

In: Journal of Urology Vol. 183, No. 4S ( 2010-04)

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In: Journal of Urology, Ovid Technologies (Wolters Kluwer Health), Vol. 183, No. 4S ( 2010-04)

Type of Medium: Online Resource

ISSN: 0022-5347 , 1527-3792

URL: Article

DOI: 10.1016/j.juro.2010.02.1160

RVK:

XA 10000

Language: English

Publisher: Ovid Technologies (Wolters Kluwer Health)

Publication Date: 2010

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EFFECTS OF NOVEL COATINGS INSPIRED BY MARINE MUSSELS ON URETERAL STENT ENCRUSTATION AND UROPATHOGEN ADHERENCE IN VIVO

Wignall, Geoffrey R ; Pechey, Andrea ; Elwood, Chelsea N ; [et al.]

Ovid Technologies (Wolters Kluwer Health) ; 2008

In: Journal of Urology Vol. 179, No. 4S ( 2008-04), p. 85-85

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In: Journal of Urology, Ovid Technologies (Wolters Kluwer Health), Vol. 179, No. 4S ( 2008-04), p. 85-85

Type of Medium: Online Resource

ISSN: 0022-5347 , 1527-3792

URL: Article

DOI: 10.1016/S0022-5347(08)60248-7

RVK:

XA 10000

Language: English

Publisher: Ovid Technologies (Wolters Kluwer Health)

Publication Date: 2008

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Novel in vitro model for studying ureteric stent-induced cell injury

Elwood, Chelsea N. ; Lange, Dirk ; Nadeau, Richard ; [et al.]

Wiley ; 2010

In: BJU International Vol. 105, No. 9 ( 2010-05), p. 1318-1323

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In: BJU International, Wiley, Vol. 105, No. 9 ( 2010-05), p. 1318-1323

Type of Medium: Online Resource

ISSN: 1464-4096 , 1464-410X

URL: Issue

URL: Article

DOI: 10.1111/bju.2010.105.issue-9

DOI: 10.1111/j.1464-410X.2009.09001.x

Language: English

Publisher: Wiley

Publication Date: 2010

detail.hit.zdb_id: 2019983-1

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Triclosan Inhibits Uropathogenic Escherichia coli -Stimulated Tumor Necrosis Factor- α Secretion in T24 Bladder Cells in Vitro

Elwood, Chelsea N. ; Chew, Ben H. ; Seney, Shannon ; [et al.]

Mary Ann Liebert Inc ; 2007

In: Journal of Endourology Vol. 21, No. 10 ( 2007-10), p. 1217-1222

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In: Journal of Endourology, Mary Ann Liebert Inc, Vol. 21, No. 10 ( 2007-10), p. 1217-1222

Type of Medium: Online Resource

ISSN: 0892-7790 , 1557-900X

URL: Article

DOI: 10.1089/end.2007.9903

Language: English

Publisher: Mary Ann Liebert Inc

Publication Date: 2007

detail.hit.zdb_id: 2030846-2

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