In:
British Journal of Haematology, Wiley, Vol. 13, No. 5 ( 1967-09), p. 656-664
Abstract:
The high serum lactate dehydrogenase activity found in megaloblastosis is almost entirely due to major increases in the anodic isoenzymes. Since the cathodic fractions predominate in the liver, gastric mucosa, lymphatic tissue and peripheral leucocytes these tissues are unlikely to be responsible for the raised serum activity. Of the tissues rich in anodic isoenzymes, the heart and kidney are not considered to be important contributors since, in the case of the former, there is no associated increase in aspartate transaminase activity, and the latter does not undergo major tissue damage in megaloblastosis. The amount of peripheral haemolysis which occurs in pernicious anaemia is not considered to account for more than a small part of the increased enzyme activity in the serum. The lactate dehydrogenase of megaloblastic bone marrow consists principally of anodic isoenzymes whereas that of normal marrow is largely cathodic, and the very high rate of destruction of immature and abnormal erythroid precursors in the bone marrow of patients with megaloblastosis is considered to be the most likely source of the raised serum enzyme activity.
Type of Medium:
Online Resource
ISSN:
0007-1048
,
1365-2141
DOI:
10.1111/bjh.1967.13.issue-5
DOI:
10.1111/j.1365-2141.1967.tb08831.x
Language:
English
Publisher:
Wiley
Publication Date:
1967
detail.hit.zdb_id:
1475751-5
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