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Hot on the Trail of Kinesin-1 with MINFLUX

Matthias, Jessica ; Wolff, Jan O ; Scheiderer, Lukas ; [et al.]

Oxford University Press (OUP) ; 2023

In: Microscopy and Microanalysis Vol. 29, No. Supplement_1 ( 2023-07-22), p. 1077-1077

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In: Microscopy and Microanalysis, Oxford University Press (OUP), Vol. 29, No. Supplement_1 ( 2023-07-22), p. 1077-1077

Type of Medium: Online Resource

ISSN: 1431-9276 , 1435-8115

URL: Article

DOI: 10.1093/micmic/ozad067.553

Language: English

Publisher: Oxford University Press (OUP)

Publication Date: 2023

detail.hit.zdb_id: 1481716-0

SSG: 11

SSG: 12

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MINFLUX dissects the unimpeded walking of kinesin-1

Wolff, Jan O. ; Scheiderer, Lukas ; Engelhardt, Tobias ; [et al.]

American Association for the Advancement of Science (AAAS) ; 2023

In: Science Vol. 379, No. 6636 ( 2023-03-10), p. 1004-1010

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In: Science, American Association for the Advancement of Science (AAAS), Vol. 379, No. 6636 ( 2023-03-10), p. 1004-1010

Abstract: A high-resolution MINFLUX microscopy approach reveals kinesin steps, substeps, and rotations.

Type of Medium: Online Resource

ISSN: 0036-8075 , 1095-9203

URL: Article

DOI: 10.1126/science.ade2650

RVK:

TA 1000

RVK:

WA 15000

Language: English

Publisher: American Association for the Advancement of Science (AAAS)

Publication Date: 2023

detail.hit.zdb_id: 128410-1

detail.hit.zdb_id: 2066996-3

detail.hit.zdb_id: 2060783-0

SSG: 11

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Thrombolysis and clinical outcome in patients with stroke after implementation of the Tyrol Stroke Pathway: a retrospective observational study

Willeit, Johann ; Geley, Theresa ; Schöch, Johannes ; [et al.]

Elsevier BV ; 2015

In: The Lancet Neurology Vol. 14, No. 1 ( 2015-01), p. 48-56

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In: The Lancet Neurology, Elsevier BV, Vol. 14, No. 1 ( 2015-01), p. 48-56

Type of Medium: Online Resource

ISSN: 1474-4422

URL: Article

DOI: 10.1016/S1474-4422(14)70286-8

Language: English

Publisher: Elsevier BV

Publication Date: 2015

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Occurrence of Zearalenone-4-β- d -glucopyranoside in Wheat

Schneweis, Isabell ; Meyer, Karsten ; Engelhardt, Gabriele ; [et al.]

American Chemical Society (ACS) ; 2002

In: Journal of Agricultural and Food Chemistry Vol. 50, No. 6 ( 2002-03-01), p. 1736-1738

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In: Journal of Agricultural and Food Chemistry, American Chemical Society (ACS), Vol. 50, No. 6 ( 2002-03-01), p. 1736-1738

Type of Medium: Online Resource

ISSN: 0021-8561 , 1520-5118

URL: Article

DOI: 10.1021/jf010802t

Language: English

Publisher: American Chemical Society (ACS)

Publication Date: 2002

detail.hit.zdb_id: 1483109-0

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Three-dimensional organization of promyelocytic leukemia nuclear bodies

Lang, Marion ; Jegou, Thibaud ; Chung, Inn ; [et al.]

The Company of Biologists ; 2010

In: Journal of Cell Science Vol. 123, No. 3 ( 2010-02-01), p. 392-400

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In: Journal of Cell Science, The Company of Biologists, Vol. 123, No. 3 ( 2010-02-01), p. 392-400

Abstract: Promyelocytic leukemia nuclear bodies (PML-NBs) are mobile subnuclear organelles formed by PML and Sp100 protein. They have been reported to have a role in transcription, DNA replication and repair, telomere lengthening, cell cycle control and tumor suppression. We have conducted high-resolution 4Pi fluorescence laser-scanning microscopy studies complemented with correlative electron microscopy and investigations of the accessibility of the PML-NB subcompartment. During interphase PML-NBs adopt a spherical organization characterized by the assembly of PML and Sp100 proteins into patches within a 50- to 100-nm-thick shell. This spherical shell of PML and Sp100 imposes little constraint to the exchange of components between the PML-NB interior and the nucleoplasm. Post-translational SUMO modifications, telomere repeats and heterochromatin protein 1 were found to localize in characteristic patterns with respect to PML and Sp100. From our findings, we derived a model that explains how the three-dimensional organization of PML-NBs serves to concentrate different biological activities while allowing for an efficient exchange of components.

Type of Medium: Online Resource

ISSN: 1477-9137 , 0021-9533

URL: Article

DOI: 10.1242/jcs.053496

Language: English

Publisher: The Company of Biologists

Publication Date: 2010

detail.hit.zdb_id: 219171-4

detail.hit.zdb_id: 1483099-1

SSG: 12

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Stroke Care Pathway ensures high-quality stroke management in the COVID-19 pandemic

Mayer-Suess, Lukas ; ter Telgte, Annemieke ; Praxmarer, Silvia ; [et al.]

Springer Science and Business Media LLC ; 2023

In: Scientific Reports Vol. 13, No. 1 ( 2023-04-05)

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In: Scientific Reports, Springer Science and Business Media LLC, Vol. 13, No. 1 ( 2023-04-05)

Abstract: The aim of our study was to assess whether a well-established federal state-wide Stroke Care Pathway delivering high quality stroke care can cope with the COVID-19 pandemic and associated measures to contain the virus spread. The retrospective analysis is based on a prospective, quality-controlled, population-based registry of all stroke patients in the Tyrol, a federal state of Austria and one of the early hot-spots of COVID-19 in Europe. Patient characteristics, pre-hospital management, intra-hospital management and post-hospital were analysed. All residents of the Tyrol suffering ischemic stroke in 2020 (n = 1160) and four pre-COVID-19 years (n = 4321) were evaluated. In 2020, the annual number of stroke patients was the highest in this population-based registry. When local hospitals were overwhelmed with SARS-CoV-2-patients, stroke subjects were temporarily allocated to the comprehensive stroke centre. Stroke severity, quality metrics of stroke management, serious complications, and post-stroke mortality did not differ between 2020 and the four comparator years. Notably, iv. thrombolysis-rate was similar (19.9% versus 17.4%, P = 0.25) and endovascular stroke treatment even better (5.9% versus 3.9%, P = 0.003) but resources for in-patient rehabilitation were limited (25.8% versus 29.8%, P = 0.009). Concluding, a well-established Stroke Care Pathway was able to maintain high-quality acute stroke care even when challenged by a global pandemic.

Type of Medium: Online Resource

ISSN: 2045-2322

URL: Article

DOI: 10.1038/s41598-023-32586-5

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2023

detail.hit.zdb_id: 2615211-3

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Maturation-Dependent HIV-1 Surface Protein Redistribution Revealed by Fluorescence Nanoscopy

Chojnacki, Jakub ; Staudt, Thorsten ; Glass, Bärbel ; [et al.]

American Association for the Advancement of Science (AAAS) ; 2012

In: Science Vol. 338, No. 6106 ( 2012-10-26), p. 524-528

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In: Science, American Association for the Advancement of Science (AAAS), Vol. 338, No. 6106 ( 2012-10-26), p. 524-528

Abstract: Human immunodeficiency virus type 1 (HIV-1) buds from the cell as an immature particle requiring subsequent proteolysis of the main structural polyprotein Gag for morphological maturation and infectivity. Visualization of the viral envelope (Env) glycoprotein distribution on the surface of individual HIV-1 particles with stimulated emission depletion (STED) superresolution fluorescence microscopy revealed maturation-induced clustering of Env proteins that depended on the Gag-interacting Env tail. Correlation of Env surface clustering with the viral entry efficiency revealed coupling between the viral interior and exterior: Rearrangements of the inner protein lattice facilitated the alteration of the virus surface in preparation for productive entry. We propose that Gag proteolysis-dependent clustering of the sparse Env trimers on the viral surface may be an essential aspect of HIV-1 maturation.

Type of Medium: Online Resource

ISSN: 0036-8075 , 1095-9203

URL: Article

DOI: 10.1126/science.1226359

RVK:

TA 1000

RVK:

WA 15000

Language: English

Publisher: American Association for the Advancement of Science (AAAS)

Publication Date: 2012

detail.hit.zdb_id: 128410-1

detail.hit.zdb_id: 2066996-3

detail.hit.zdb_id: 2060783-0

SSG: 11

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Reversible Light-, Thermo-, and Mechano-Responsive Elastomeric Polymer Opal Films

Schäfer, Christian G. ; Gallei, Markus ; Zahn, Jasmin T. ; [et al.]

American Chemical Society (ACS) ; 2013

In: Chemistry of Materials Vol. 25, No. 11 ( 2013-06-11), p. 2309-2318

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In: Chemistry of Materials, American Chemical Society (ACS), Vol. 25, No. 11 ( 2013-06-11), p. 2309-2318

Type of Medium: Online Resource

ISSN: 0897-4756 , 1520-5002

URL: Article

DOI: 10.1021/cm400911j

Language: English

Publisher: American Chemical Society (ACS)

Publication Date: 2013

detail.hit.zdb_id: 1500399-1

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A STED MICROSCOPE DESIGNED FOR ROUTINE BIOMEDICAL APPLICATIONS (Invited Paper)

Gorlitz, Frederik ; Hoyer, Patrick ; Falk, Henning ; [et al.]

The Electromagnetics Academy ; 2014

In: Progress In Electromagnetics Research Vol. 147 ( 2014), p. 57-68

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In: Progress In Electromagnetics Research, The Electromagnetics Academy, Vol. 147 ( 2014), p. 57-68

Type of Medium: Online Resource

ISSN: 1559-8985

URL: Article

DOI: 10.2528/PIER14042708

Language: English

Publisher: The Electromagnetics Academy

Publication Date: 2014

detail.hit.zdb_id: 2241936-6

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Fluorescent-Protein Stabilization and High-Resolution Imaging of Cleared, Intact Mouse Brains

Schwarz, Martin K. ; Scherbarth, Annemarie ; Sprengel, Rolf ; [et al.]

Public Library of Science (PLoS) ; 2015

In: PLOS ONE Vol. 10, No. 5 ( 2015-5-20), p. e0124650-

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In: PLOS ONE, Public Library of Science (PLoS), Vol. 10, No. 5 ( 2015-5-20), p. e0124650-

Type of Medium: Online Resource

ISSN: 1932-6203

URL: Article

DOI: 10.1371/journal.pone.0124650

DOI: 10.1371/journal.pone.0124650.g001

DOI: 10.1371/journal.pone.0124650.g002

DOI: 10.1371/journal.pone.0124650.g003

DOI: 10.1371/journal.pone.0124650.g004

DOI: 10.1371/journal.pone.0124650.g005

DOI: 10.1371/journal.pone.0124650.g006

DOI: 10.1371/journal.pone.0124650.g007

DOI: 10.1371/journal.pone.0124650.t001

DOI: 10.1371/journal.pone.0124650.t002

DOI: 10.1371/journal.pone.0124650.s001

DOI: 10.1371/journal.pone.0124650.s002

DOI: 10.1371/journal.pone.0124650.s003

DOI: 10.1371/journal.pone.0124650.s004

DOI: 10.1371/journal.pone.0124650.s005

DOI: 10.1371/journal.pone.0124650.s006

DOI: 10.1371/journal.pone.0124650.s007

DOI: 10.1371/journal.pone.0124650.s008

DOI: 10.1371/journal.pone.0124650.s009

DOI: 10.1371/journal.pone.0124650.s010

Language: English

Publisher: Public Library of Science (PLoS)

Publication Date: 2015

detail.hit.zdb_id: 2267670-3

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