In:
Science Translational Medicine, American Association for the Advancement of Science (AAAS), Vol. 15, No. 687 ( 2023-03-15)
Abstract:
Most of the population has some immunity to SARS-CoV-2 as a result of prior infection, vaccination, or both. Hybrid immunity to SARS-CoV-2, where an individual has immune memory conferred by both infection and vaccination, is thought to provide superior protection against the virus, though this merits experimental investigation. To that end, Barateau and colleagues conducted a longitudinal analysis comparing individuals who had SARS-CoV-2-specific immunity elicited by infection, vaccination, or both. The authors found that those with hybrid immunity (infection followed by vaccination) had the most robust spike protein–specific antibody response of those analyzed. Individuals with hybrid immunity also presented a distinct CD4 + T and B memory cell landscape. Together, the results of this highlight the superiority of hybrid immunity and suggest that those with prior SARS-CoV-2 infection should still be included in vaccination campaigns. —CM
Type of Medium:
Online Resource
ISSN:
1946-6234
,
1946-6242
DOI:
10.1126/scitranslmed.ade0550
Language:
English
Publisher:
American Association for the Advancement of Science (AAAS)
Publication Date:
2023
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