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The percentage of CD39+ monocytes is higher in pregnant COVID-19+ patients than in nonpregnant COVID-19+ patients

Cérbulo-Vázquez, A. ; García-Espinosa, M. ; Briones-Garduño, J. C. ; [et al.]

Public Library of Science (PLoS) ; 2022

In: PLOS ONE Vol. 17, No. 7 ( 2022-7-28), p. e0264566-

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In: PLOS ONE, Public Library of Science (PLoS), Vol. 17, No. 7 ( 2022-7-28), p. e0264566-

Abstract: Current medical guidelines consider pregnant women with COVID-19 to be a high-risk group. Since physiological gestation downregulates the immunological response to maintain “maternal-fetal tolerance”, SARS-CoV-2 infection may constitute a potentially threatening condition to both the mother and the fetus. To establish the immune profile in pregnant COVID-19+ patients, a cross-sectional study was conducted. Pregnant women with COVID-19 (P-COVID-19+; n = 15) were analyzed and compared with nonpregnant women with COVID-19 (NP-COVID-19+; n = 15) or those with physiological pregnancy (P-COVID-19-; n = 13). Serological cytokine and chemokine concentrations, leucocyte immunophenotypes, and mononuclear leucocyte responses to polyclonal stimuli were analyzed in all groups. Higher concentrations of serological TNF-α, IL-6, MIP1b and IL-4 were observed within the P-COVID-19+ group, while cytokines and chemokines secreted by peripheral leucocytes in response to LPS, IL-6 or PMA-ionomicin were similar among the groups. Immunophenotype analysis showed a lower percentage of HLA-DR+ monocytes in P-COVID-19+ than in P-COVID-19- and a higher percentage of CD39+ monocytes in P-COVID-19+ than in NP-COVID-19+. After whole blood polyclonal stimulation, similar percentages of T cells and TNF+ monocytes between groups were observed. Our results suggest that P-COVID-19+ elicits a strong inflammatory response similar to NP-COVID19+ but also displays an anti-inflammatory response that controls the ATP/adenosine balance and prevents hyperinflammatory damage in COVID-19.

Type of Medium: Online Resource

ISSN: 1932-6203

URL: Article

DOI: 10.1371/journal.pone.0264566

DOI: 10.1371/journal.pone.0264566.g001

DOI: 10.1371/journal.pone.0264566.g002

DOI: 10.1371/journal.pone.0264566.g003

DOI: 10.1371/journal.pone.0264566.g004

DOI: 10.1371/journal.pone.0264566.t001

DOI: 10.1371/journal.pone.0264566.t002

DOI: 10.1371/journal.pone.0264566.s001

DOI: 10.1371/journal.pone.0264566.s002

DOI: 10.1371/journal.pone.0264566.s003

DOI: 10.1371/journal.pone.0264566.s004

DOI: 10.1371/journal.pone.0264566.s005

DOI: 10.1371/journal.pone.0264566.s006

DOI: 10.1371/journal.pone.0264566.s007

DOI: 10.1371/journal.pone.0264566.r001

DOI: 10.1371/journal.pone.0264566.r002

DOI: 10.1371/journal.pone.0264566.r003

DOI: 10.1371/journal.pone.0264566.r004

Language: English

Publisher: Public Library of Science (PLoS)

Publication Date: 2022

detail.hit.zdb_id: 2267670-3

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Lung pathology due to hRSV infection impairs blood–brain barrier permeability enabling astrocyte infection and a long-lasting inflammation in the CNS

Bohmwald, Karen ; Soto, Jorge A. ; Andrade-Parra, Catalina ; [et al.]

Elsevier BV ; 2021

In: Brain, Behavior, and Immunity Vol. 91 ( 2021-01), p. 159-171

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In: Brain, Behavior, and Immunity, Elsevier BV, Vol. 91 ( 2021-01), p. 159-171

Type of Medium: Online Resource

ISSN: 0889-1591

URL: Article

DOI: 10.1016/j.bbi.2020.09.021

Language: English

Publisher: Elsevier BV

Publication Date: 2021

detail.hit.zdb_id: 1462491-6

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Gestational Hypothyroidism Increases the Severity of Experimental Autoimmune Encephalomyelitis in Adult Offspring

Albornoz, Eduardo A. ; Carreño, Leandro J. ; Cortes, Claudia M. ; [et al.]

Mary Ann Liebert Inc ; 2013

In: Thyroid Vol. 23, No. 12 ( 2013-12), p. 1627-1637

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In: Thyroid, Mary Ann Liebert Inc, Vol. 23, No. 12 ( 2013-12), p. 1627-1637

Type of Medium: Online Resource

ISSN: 1050-7256 , 1557-9077

URL: Article

DOI: 10.1089/thy.2012.0401

Language: English

Publisher: Mary Ann Liebert Inc

Publication Date: 2013

detail.hit.zdb_id: 2030622-2

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Veterans’ Perspectives on Interventions to Improve Retention in HIV Care

Minick, Sophie G. ; Stafford, Crystal L. ; Kertz, Barbara L. ; [et al.]

Public Library of Science (PLoS) ; 2016

In: PLOS ONE Vol. 11, No. 2 ( 2016-2-1), p. e0148163-

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In: PLOS ONE, Public Library of Science (PLoS), Vol. 11, No. 2 ( 2016-2-1), p. e0148163-

Type of Medium: Online Resource

ISSN: 1932-6203

URL: Article

DOI: 10.1371/journal.pone.0148163

DOI: 10.1371/journal.pone.0148163.g001

DOI: 10.1371/journal.pone.0148163.g002

DOI: 10.1371/journal.pone.0148163.t001

DOI: 10.1371/journal.pone.0148163.s001

DOI: 10.1371/journal.pone.0148163.s002

DOI: 10.1371/journal.pone.0148163.s003

DOI: 10.1371/journal.pone.0148163.s004

DOI: 10.1371/journal.pone.0148163.s005

DOI: 10.1371/journal.pone.0148163.s006

Language: English

Publisher: Public Library of Science (PLoS)

Publication Date: 2016

detail.hit.zdb_id: 2267670-3

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HIV gp120 Protein Increases the Function of Connexin 43 Hemichannels and Pannexin-1 Channels in Astrocytes: Repercussions on Astroglial Function

Gajardo-Gómez, Rosario ; Santibañez, Cristian A. ; Labra, Valeria C. ; [et al.]

MDPI AG ; 2020

In: International Journal of Molecular Sciences Vol. 21, No. 7 ( 2020-04-03), p. 2503-

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In: International Journal of Molecular Sciences, MDPI AG, Vol. 21, No. 7 ( 2020-04-03), p. 2503-

Abstract: At least half of human immunodeficiency virus (HIV)-infected individuals suffer from a wide range of cognitive, behavioral and motor deficits, collectively known as HIV-associated neurocognitive disorders (HAND). The molecular mechanisms that amplify damage within the brain of HIV-infected individuals are unknown. Recently, we described that HIV augments the opening of connexin-43 (Cx43) hemichannels in cultured human astrocytes, which result in the collapse of neuronal processes. Whether HIV soluble viral proteins such as gp120, can regulate hemichannel opening in astrocytes is still ignored. These channels communicate the cytosol with the extracellular space during pathological conditions. We found that gp120 enhances the function of both Cx43 hemichannels and pannexin-1 channels in mouse cortical astrocytes. These effects depended on the activation of IL-1β/TNF-α, p38 MAP kinase, iNOS, cytoplasmic Ca2+ and purinergic signaling. The gp120-induced channel opening resulted in alterations in Ca2+ dynamics, nitric oxide production and ATP release. Although the channel opening evoked by gp120 in astrocytes was reproduced in ex vivo brain preparations, these responses were heterogeneous depending on the CA1 region analyzed. We speculate that soluble gp120-induced activation of astroglial Cx43 hemichannels and pannexin-1 channels could be crucial for the pathogenesis of HAND.

Type of Medium: Online Resource

ISSN: 1422-0067

URL: Article

DOI: 10.3390/ijms21072503

Language: English

Publisher: MDPI AG

Publication Date: 2020

detail.hit.zdb_id: 2019364-6

SSG: 12

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Protective T cell immunity against respiratory syncytial virus is efficiently induced by recombinant BCG

Bueno, Susan M. ; González, Pablo A. ; Cautivo, Kelly M. ; [et al.]

Proceedings of the National Academy of Sciences ; 2008

In: Proceedings of the National Academy of Sciences Vol. 105, No. 52 ( 2008-12-30), p. 20822-20827

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In: Proceedings of the National Academy of Sciences, Proceedings of the National Academy of Sciences, Vol. 105, No. 52 ( 2008-12-30), p. 20822-20827

Abstract: Respiratory syncytial virus (RSV) is one of the leading causes of childhood hospitalization and a major health burden worldwide. Unfortunately, because of an inefficient immunological memory, RSV infection provides limited immune protection against reinfection. Furthermore, RSV can induce an inadequate Th2-type immune response that causes severe respiratory tract inflammation and obstruction. It is thought that effective RSV clearance requires the induction of balanced Th1-type immunity, involving the activation of IFN-γ-secreting cytotoxic T cells. A recognized inducer of Th1 immunity is Mycobacterium bovis bacillus Calmette–Guérin (BCG), which has been used in newborns for decades in several countries as a tuberculosis vaccine. Here, we show that immunization with recombinant BCG strains expressing RSV antigens promotes protective Th1-type immunity against RSV in mice. Activation of RSV-specific T cells producing IFN-γ and IL-2 was efficiently obtained after immunization with recombinant BCG. This type of T cell immunity was protective against RSV challenge and caused a significant reduction of inflammatory cell infiltration in the airways. Furthermore, mice immunized with recombinant BCG showed no weight loss and reduced lung viral loads. These data strongly support recombinant BCG as an efficient vaccine against RSV because of its capacity to promote protective Th1 immunity.

Type of Medium: Online Resource

ISSN: 0027-8424 , 1091-6490

URL: Article

DOI: 10.1073/pnas.0806244105

RVK:

TA 1000

RVK:

WA 15000

Language: English

Publisher: Proceedings of the National Academy of Sciences

Publication Date: 2008

detail.hit.zdb_id: 209104-5

detail.hit.zdb_id: 1461794-8

SSG: 11

SSG: 12

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Evidence for the Convergence Model: The Emergence of Highly Pathogenic Avian Influenza (H5N1) in Viet Nam

Saksena, Sumeet ; Fox, Jefferson ; Epprecht, Michael ; [et al.]

Public Library of Science (PLoS) ; 2015

In: PLOS ONE Vol. 10, No. 9 ( 2015-9-23), p. e0138138-

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In: PLOS ONE, Public Library of Science (PLoS), Vol. 10, No. 9 ( 2015-9-23), p. e0138138-

Type of Medium: Online Resource

ISSN: 1932-6203

URL: Article

DOI: 10.1371/journal.pone.0138138

DOI: 10.1371/journal.pone.0138138.g001

DOI: 10.1371/journal.pone.0138138.t001

DOI: 10.1371/journal.pone.0138138.t002

DOI: 10.1371/journal.pone.0138138.t003

DOI: 10.1371/journal.pone.0138138.t004

DOI: 10.1371/journal.pone.0138138.t005

DOI: 10.1371/journal.pone.0138138.t006

DOI: 10.1371/journal.pone.0138138.t007

Language: English

Publisher: Public Library of Science (PLoS)

Publication Date: 2015

detail.hit.zdb_id: 2267670-3

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Serological Evidence for Non-Lethal Exposures of Mongolian Wild Birds to Highly Pathogenic Avian Influenza H5N1 Virus

Gilbert, Martin ; Koel, Björn F. ; Bestebroer, Theo M. ; [et al.]

Public Library of Science (PLoS) ; 2014

In: PLoS ONE Vol. 9, No. 12 ( 2014-12-15), p. e113569-

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In: PLoS ONE, Public Library of Science (PLoS), Vol. 9, No. 12 ( 2014-12-15), p. e113569-

Type of Medium: Online Resource

ISSN: 1932-6203

URL: Article

DOI: 10.1371/journal.pone.0113569

DOI: 10.1371/journal.pone.0113569.g001

DOI: 10.1371/journal.pone.0113569.t001

DOI: 10.1371/journal.pone.0113569.t002

DOI: 10.1371/journal.pone.0113569.t003

DOI: 10.1371/journal.pone.0113569.t004

DOI: 10.1371/journal.pone.0113569.s001

DOI: 10.1371/journal.pone.0113569.s002

DOI: 10.1371/journal.pone.0113569.s003

DOI: 10.1371/journal.pone.0113569.s004

DOI: 10.1371/journal.pone.0113569.s005

DOI: 10.1371/journal.pone.0113569.s006

DOI: 10.1371/journal.pone.0113569.s007

Language: English

Publisher: Public Library of Science (PLoS)

Publication Date: 2014

detail.hit.zdb_id: 2267670-3

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Inflammatory conditions induce gap junctional communication between rat Kupffer cells both in vivo and in vitro

Eugenín, Eliseo A. ; González, Hernán E. ; Sánchez, Helmuth A. ; [et al.]

Elsevier BV ; 2007

In: Cellular Immunology Vol. 247, No. 2 ( 2007-06), p. 103-110

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In: Cellular Immunology, Elsevier BV, Vol. 247, No. 2 ( 2007-06), p. 103-110

Type of Medium: Online Resource

ISSN: 0008-8749

URL: Article

DOI: 10.1016/j.cellimm.2007.08.001

RVK:

XA 10000

Language: English

Publisher: Elsevier BV

Publication Date: 2007

detail.hit.zdb_id: 1462601-9

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Cellular neuropathologic effects of hemozoin, a toxin produced by Plasmodium falciparum, the causative agent of human malaria (B121)

Martiney, James A ; Harkins, Caroline ; Berman, Joan W ; [et al.]

The American Association of Immunologists ; 2007

In: The Journal of Immunology Vol. 178, No. 1_Supplement ( 2007-04-01), p. LB25-LB25

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In: The Journal of Immunology, The American Association of Immunologists, Vol. 178, No. 1_Supplement ( 2007-04-01), p. LB25-LB25

Abstract: Malaria, caused by an intracellular protozoan parasite of the genus Plasmodium, is responsible for 2–3 million deaths and 300–500 acute illnesses annually. A major morbidity factor is cerebral malaria, characterized by enhanced blood-brain barrier permeability, leukocyte infiltration and/or activation, and neuronal dropout. The pathogenesis of cerebral malaria remains unknown. Hemozoin, a by-product of intraerythrocytic parasite mediated hemoglobin catabolism, is released when the parasite lyses the host erythrocyte. This potential toxin is found in the brain parenchyma of cerebral malaria cases. The effects, if any, of hemozoin on human brain cells has not been studied in detail. Our data demonstrates that astrocytes actively phagocytize hemozoin, resulting in a time and concentration dependent toxicity and loss of viability. Further analysis demonstrated a secondary loss of neurons in astrocyte-neuron co-cultures. Morphologic characteristics of apoptosis such as membrane blebbing were observed in astrocytes exposed to hemozoin. Apoptosis was subsequently corroborated via Western blot analyses and TUNEL confocal microscopy. Taken together, our results suggests that hemozoin can induce significant pathogenic responses in CNS cells that can contribute to the development of cerebral malaria. This work was supported by the NIH Centers for AIDS Research Grant AI-051519 and particularly by a KO1 grant from the National Institute of Mental Health to E.A.E. (MH076679).

Type of Medium: Online Resource

ISSN: 0022-1767 , 1550-6606

URL: Article

DOI: 10.4049/jimmunol.178.Supp.B121

RVK:

XA 54100

RVK:

XA 10000

Language: English

Publisher: The American Association of Immunologists

Publication Date: 2007

detail.hit.zdb_id: 1475085-5

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