In:
European Journal of Endocrinology, Oxford University Press (OUP), Vol. 183, No. 3 ( 2020-09), p. 297-306
Abstract:
Glucocorticoids (GC) are associated with increased cardiovascular morbidity despite increased HDL-C concentration. HDL-mediated cholesterol efflux, a major anti-atherogenic property of HDL particles, is negatively associated with CVD risk. We aimed to determine whether HDL-mediated cholesterol efflux was influenced by GC. Design: Prospective, observational study. Methods: Lipid parameters, HDL composition, HDL-mediated cholesterol efflux, cholesteryl ester transfer protein, phospholipid transfer protein and lecithin cholesterol acyl-transferase (LCAT) activities were determined in ten patients with giant cell arteritis before and 3 months after GC introduction and in seven control subjects. HDL concentration and composition, HDL-mediated cholesterol efflux and LCAT activity were determined in GC-treated mice. Results: In patients, HDL-C concentration was higher after than before treatment GC-treatment ( P = 0.002), while HDL-mediated cholesterol efflux was decreased ( P = 0.008) and negatively associated with the proportion of cholesteryl ester in HDL ( P = 0.04), independently of CRP. As well, in mice, HDL-C level was increased after GC exposure ( P = 0.04) and HDL-mediated cholesterol efflux decreased ( P = 0.04). GC-treated patients had higher cholesteryl ester content in HDL, higher HDL 2 -to-HDL 3 ratio and higher LCAT activity than before treatment ( P = 0.008, P = 0.02 and P = 0.004, respectively). Conclusions: We report, for the first time, that in patients with giant cell arteritis and mice treated with GC, HDL-mediated cholesterol efflux was impaired by GC besides an increased HDL-C level. This impaired HDL functionality, possibly related to HDL enrichment in cholesteryl ester, could contribute to the increased CVD risk observed in GC-treated patients. Further studies are needed in larger populations, to further decipher the effect of GC on HDL.
Type of Medium:
Online Resource
ISSN:
0804-4643
,
1479-683X
Language:
Unknown
Publisher:
Oxford University Press (OUP)
Publication Date:
2020
detail.hit.zdb_id:
1485160-X
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