In:
Acta Endocrinologica, Oxford University Press (OUP), Vol. 92, No. 3 ( 1979-11), p. 532-541
Abstract:
The relationship between serum levels of growth hormone (rGH), prolactin (rPRL), lutenizing hormone (rLH), follicle-stimulating hormone (rFSH), corticosterone, oestrogen, (oestradiol-17β) and testosterone and the hepatic binding sites specific to [ 125 I]human-prolactin (h-PRL) were investigated in normal rats, in rats bearing the GH- and PRL-secreting tumour (GH 3 ), and in rats 14 days after tumour removal. The presence of GH 3 tumour elevated serum levels of rGH and rPRL and concomitantly increased the hepatic binding of [ 125 I] h-PRL; the male rats had a greater increase than the female rats. The increased binding was due to an increase in the specific membrane binding sites, whereas the affinity constant (Ka) was not changed. In both male and female rats, there was a significant positive correlation between serum rGH levels ( P 〈 0.001) or serum rPRL ( P 〈 0.02) and specific binding of [ 125 1] h-PRL in female rats only ( P 〈 0.02). In male rats, there was a significant negative correlation between serum testosterone levels and specific bindings of [ 125 I]h-PRL ( P 〈 0.05). These results suggest that rGH and rPRL regulates the hepatic h-PRL receptors in female rats, and testosterone predominantly inhibits the induction of the hepatic lactogenic receptors in male rats.
Type of Medium:
Online Resource
ISSN:
0804-4643
,
1479-683X
DOI:
10.1530/acta.0.0920532
Language:
Unknown
Publisher:
Oxford University Press (OUP)
Publication Date:
1979
detail.hit.zdb_id:
1485160-X
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