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1

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Simple and efficient technique for evaluating the optical losses from surface scattering and volume attenuation in a thin film

Zhang, Xi-Jing ; Fan, Xi-Zhi ; Wang, Hui-Tian ; [et al.]

Optica Publishing Group ; 2002

In: Optics Express Vol. 10, No. 25 ( 2002-12-16), p. 1485-

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In: Optics Express, Optica Publishing Group, Vol. 10, No. 25 ( 2002-12-16), p. 1485-

Type of Medium: Online Resource

ISSN: 1094-4087

URL: Article

DOI: 10.1364/OE.10.001485

Language: English

Publisher: Optica Publishing Group

Publication Date: 2002

detail.hit.zdb_id: 1491859-6

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2

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Properties of leaky and degenerate modes in a prism–film coupler with waveguide structure

Zhang, Xi-Jing ; Fan, Xi-Zhi ; Yan, Jun ; [et al.]

AIP Publishing ; 2003

In: Journal of Applied Physics Vol. 94, No. 11 ( 2003-12-01), p. 7025-7030

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In: Journal of Applied Physics, AIP Publishing, Vol. 94, No. 11 ( 2003-12-01), p. 7025-7030

Abstract: A laser beam can be efficiently fed into a planar thin film by means of a prism–film coupler. The properties of the cavity modes, the coupling efficiency, the optimum coupling condition, etc. of the prism–film coupler can be explained using the theory developed by Tien and Ulrich [P. K. Tien and R. Ulrich, J. Opt. Soc. Am. 60, 1325 (1970)]. Based on multiple scattering and multiple wave interference, we propose a theory of the two modes referred to as the leaky and degenerate modes. The properties of the two kinds of modes, such as positions, linewidths, angular spectrum of the leaky mode, and the degenerate mode spectrum are studied in detail. This theory gives an excellent explanation of the underlying origin of light wave propagation in the prism–film coupler.

Type of Medium: Online Resource

ISSN: 0021-8979 , 1089-7550

URL: Article

DOI: 10.1063/1.1624485

Language: English

Publisher: AIP Publishing

Publication Date: 2003

detail.hit.zdb_id: 220641-9

detail.hit.zdb_id: 3112-4

detail.hit.zdb_id: 1476463-5

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3

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Propagation properties of a light wave in a film quasiwaveguide structure

Zhang, Xi-Jing ; Fan, Xi-Zhi ; Liao, Jun ; [et al.]

AIP Publishing ; 2002

In: Journal of Applied Physics Vol. 92, No. 10 ( 2002-11-15), p. 5647-5657

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In: Journal of Applied Physics, AIP Publishing, Vol. 92, No. 10 ( 2002-11-15), p. 5647-5657

Abstract: We suggest a three-dimensional theoretical model to explain the origin of light wave propagation in a quasiwaveguide structure formed by a thin film of refractive index smaller than the substrate. The physical principles involved are illustrated by the use of a combination of multiple-wave interference and coherent multiple scattering. Not only the theoretical details and the important analytic formulas describing the properties of wave propagation in the quasiwaveguide were given, but also the positions and linewidths of the quasiwaveguide modes, the intensity distribution in the film, the intensity of the reflected spot, and the intensity distribution of the scattered light (m lines) are studied in detail. We divide the modes in the quasiwaveguide into three kinds: cavity modes, leaky modes, and degenerate modes. Some interesting problems are discussed. We investigate the properties of wave propagation in a quasiwaveguide made with a doped polymer film and discuss the origin of scattering.

Type of Medium: Online Resource

ISSN: 0021-8979 , 1089-7550

URL: Article

DOI: 10.1063/1.1517731

Language: English

Publisher: AIP Publishing

Publication Date: 2002

detail.hit.zdb_id: 220641-9

detail.hit.zdb_id: 3112-4

detail.hit.zdb_id: 1476463-5

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4

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Frequent amplification of HDAC genes and efficacy of HDAC inhibitor chidamide and PD-1 blockade combination in soft tissue sarcoma

Que, Yi ; Zhang, Xiao-Long ; Liu, Ze-Xian ; [et al.]

BMJ ; 2021

In: Journal for ImmunoTherapy of Cancer Vol. 9, No. 2 ( 2021-02), p. e001696-

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In: Journal for ImmunoTherapy of Cancer, BMJ, Vol. 9, No. 2 ( 2021-02), p. e001696-

Abstract: The advent of immune checkpoint therapy has been a tremendous advance in cancer treatment. However, the responses are still insufficient in patients with soft tissue sarcoma (STS). We aimed to identify rational combinations to increase the response to immune checkpoint therapy and improve survival. Methods Whole-exome sequencing (WES) was performed in 11 patients with liposarcoma. Somatic copy number alterations (SCNAs) were analyzed at the gene level to identify obvious amplification patterns in drug-target genes. The expression and prognostic value of class I histone deacetylases (HDACs) was evaluated in 49 patients with sarcoma in our center and confirmed in 263 sarcoma samples from The Tumor Cancer Genome Atlas (TCGA) database. Q-PCR, flow cytometry and RNA-seq were performed to determine the correlations between class I HDACs, chidamide and PD-L1 in vitro and in vivo. The efficacy of combining chidamide with PD-1 blockade was explored in an immunocompetent murine model and a small cohort of patients with advanced sarcoma. Western blot, ChIP assay and dual luciferase assessment were applied in the mechanistic study. Results The HDAC gene family was frequently amplified in STS. SCNAs in the HDAC gene family were extensively amplified in 8 of 11 (73%) patients with liposarcoma, based on a drug-target gene set, and we verified amplification in 76.65% (197/257) of cases by analyzing TCGA sarcoma cohort. Class I HDAC expression is associated with a poor prognosis for patients with STS, and its inhibition is responsible for promoting apoptosis and upregulating of programmed cell death ligand 1 (PD-L1). The HDAC class I inhibitor chidamide significantly increases PD-L1 expression, increased the infiltration of CD8 + T cells and reduced the number of MDSCs in the tumor microenvironment. The combination of chidamide with an anti-PD-1 antibody significantly promotes tumor regression and improves survival in a murine model. Moreover, chidamide combined with the anti-PD-1 antibody toripalimab is effective in patients with advanced and metastatic sarcoma, and the side effects are tolerable. Mechanistically, chidamide increases histone acetylation at the PD-L1 gene through the activation of the transcriptional factor STAT1. Conclusions The combination of chidamide and anti-programmed cell death 1 (PD-1) therapy represents a potentially important strategy for STS.

Type of Medium: Online Resource

ISSN: 2051-1426

URL: Article

DOI: 10.1136/jitc-2020-001696

Language: English

Publisher: BMJ

Publication Date: 2021

detail.hit.zdb_id: 2719863-7

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5

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Effects of processing on all-optical poling characteristics of guest-host azo-dye polymer thin films

Tan, Jing ; Li, Ai-Dong ; Fan, Xi-Zhi ; [et al.]

Wiley ; 2007

In: physica status solidi (a) Vol. 204, No. 4 ( 2007-04), p. 1114-1122

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In: physica status solidi (a), Wiley, Vol. 204, No. 4 ( 2007-04), p. 1114-1122

Type of Medium: Online Resource

ISSN: 1862-6300 , 1862-6319

URL: Issue

URL: Article

DOI: 10.1002/pssa.v204:4

DOI: 10.1002/pssa.200622035

Language: English

Publisher: Wiley

Publication Date: 2007

detail.hit.zdb_id: 1481091-8

detail.hit.zdb_id: 208850-2

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6

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Second Z-scan in materials with nonlinear refraction and nonlinear absorption

Guo, Sheng-Li ; Yan, Jun ; Xu, Li ; [et al.]

IOP Publishing ; 2002

In: Journal of Optics A: Pure and Applied Optics Vol. 4, No. 5 ( 2002-9-1), p. 504-508

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In: Journal of Optics A: Pure and Applied Optics, IOP Publishing, Vol. 4, No. 5 ( 2002-9-1), p. 504-508

Type of Medium: Online Resource

ISSN: 1464-4258

URL: Article

DOI: 10.1088/1464-4258/4/5/303

Language: Unknown

Publisher: IOP Publishing

Publication Date: 2002

detail.hit.zdb_id: 2532144-4

detail.hit.zdb_id: 2001913-0

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7

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Ornithine decarboxylase is involved in methyl jasmonate‐regulated postharvest quality retention in button mushrooms ( Agaricus bisporus )

Meng, De‐Mei ; Wang, Hua‐Dong ; Zhang, Ya‐Xuan ; [et al.]

Wiley ; 2019

In: Journal of the Science of Food and Agriculture Vol. 99, No. 2 ( 2019-01-30), p. 790-796

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In: Journal of the Science of Food and Agriculture, Wiley, Vol. 99, No. 2 ( 2019-01-30), p. 790-796

Abstract: In the present study, we investigated the role of ornithine decarboxylase (ODC) in the methyl jasmonate (MeJA)‐regulated postharvest quality maintenance of Agaricus bisporus (J. E. Kange) Imbach button mushrooms by pretreating mushrooms with a specific irreversible inhibitor called α ‐difluoromethylornithine (DFMO) before exposure to MeJA vapor. RESULTS Mushrooms were treated with 0 or 100 µmol L −1 MeJA or a combination of 120 µmol L −1 DFMO and 100 µmol L −1 MeJA, respectively, before storage at 4 °C for 21 days. Treatment with MeJA alone induced the increase in ODC activity whereas this effect was greatly suppressed by pretreatment with DFMO. α ‐Difluoromethylornithine strongly attenuated the effect of MeJA on decreasing cap opening, slowing the decline rate of soluble protein and total sugar, and accumulating total phenolics and flavonoids. α ‐Difluoromethylornithine pretreatment also counteracted the ability of MeJA to inhibit polyphenol oxidase and lipoxygenase activities, and malondialdehyde production, and to stimulate superoxide dismutase and catalase activities. It also largely downregulated MeJA‐induced accumulation of free putrescine (Put). CONCLUSION These results reveal that ODC is involved in MeJA‐regulated postharvest quality retention of button mushrooms, and this involvement is likely to be associated with Put levels. © 2018 Society of Chemical Industry

Type of Medium: Online Resource

ISSN: 0022-5142 , 1097-0010

URL: Issue

URL: Article

DOI: 10.1002/jsfa.2019.99.issue-2

DOI: 10.1002/jsfa.9247

Language: English

Publisher: Wiley

Publication Date: 2019

detail.hit.zdb_id: 2001807-1

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8

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Effect of Yb〈sub〉2〈/sub〉SiO〈sub〉5〈/sub〉 Ceramic Layer Thickness on the Thermal Cycling Life of Yb〈sub〉2〈/sub〉SiO〈sub〉5〈/sub〉⁄LaMgAl〈sub〉11〈/sub〉O〈sub〉19〈/sub〉 Coating Deposited on C⁄SiC Composites

Wang, Ying ; Zou, Bing Lin ; Fan, Xi Zhi ; [et al.]

Trans Tech Publications, Ltd. ; 2013

In: Key Engineering Materials Vol. 537 ( 2013-1), p. 36-41

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In: Key Engineering Materials, Trans Tech Publications, Ltd., Vol. 537 ( 2013-1), p. 36-41

Abstract: C⁄SiC composites were plasma sprayed with Yb 2 SiO 5 ⁄LaMgAl 11 O 19 (LMA) coatings with varying Yb 2 SiO 5 layer thickness. The effect of Yb 2 SiO 5 layer thickness on the thermal cycling life of the Yb 2 SiO 5 LMA coatings was investigated. The results showed that the thermal cycling life is significantly dependent on the Yb 2 SiO 5 layer thickness. It decreased from 130 cycles to 35 cycles as Yb 2 SiO 5 layer thickness increased from 50 µm to 100 µm. Further increasing Yb 2 SiO 5 layer thickness to 200 µm made it decrease to 2 cycles. The influencing mechanism of Yb 2 SiO 5 layer thickness for the thermal cycling life was clarified based on the thermal expansion behavior, the chemical stability at high temperature and the microstructure analysis.

Type of Medium: Online Resource

ISSN: 1662-9795

URL: Issue

URL: Article

DOI: 10.4028/www.scientific.net/KEM.537

DOI: 10.4028/www.scientific.net/KEM.537.36

Language: Unknown

Publisher: Trans Tech Publications, Ltd.

Publication Date: 2013

detail.hit.zdb_id: 2073306-9

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9

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Mesomorphic behavior and optical properties of liquid-crystalline polysiloxanes bearing different chiral groups

Meng, Fan-Bao ; Zhang, Bao-Yan ; Lian, Jiao ; [et al.]

Wiley ; 2009

In: Journal of Applied Polymer Science Vol. 114, No. 4 ( 2009-11-15), p. 2195-2203

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In: Journal of Applied Polymer Science, Wiley, Vol. 114, No. 4 ( 2009-11-15), p. 2195-2203

Type of Medium: Online Resource

ISSN: 0021-8995 , 1097-4628

URL: Issue

URL: Article

DOI: 10.1002/app.v114:4

DOI: 10.1002/app.30437

Language: English

Publisher: Wiley

Publication Date: 2009

detail.hit.zdb_id: 1491105-X

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10

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Poor bone mineral density aggravates adjacent segment's motility compensation in patients with oblique lumbar interbody fusion with and without pedicle screw fixation: An in silico study

Huang, Chen-Yi ; Zhang, Zi-Fan ; Zhang, Xiao-Yu ; [et al.]

Frontiers Media SA ; 2022

In: Frontiers in Surgery Vol. 9 ( 2022-8-31)

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In: Frontiers in Surgery, Frontiers Media SA, Vol. 9 ( 2022-8-31)

Abstract: Motility compensation increases the risk of adjacent segment diseases (ASDs). Previous studies have demonstrated that patients with ASD have a poor bone mineral density (BMD), and changes in BMD affect the biomechanical environment of bones and tissues, possibly leading to an increase in ASD incidence. However, whether poor BMD increases the risk of ASD by aggravating the motility compensation of the adjacent segment remains unclear. The present study aimed to clarify this relationship in oblique lumbar interbody fusion (OLIF) models with different BMDs and additional fixation methods. Methods Stand-alone (S-A) OLIF and OLIF fixed with bilateral pedicle screws (BPS) were simulated in the L4–L5 segment of our well-validated lumbosacral model. Range of motions (ROMs) and stiffness in the surgical segment and at the cranial and caudal sides’ adjacent segments were computed under flexion, extension, and unilateral bending and axial rotation loading conditions. Results Under most loading conditions, the motility compensation of both cranial and caudal segments adjacent to the OLIF segment steeply aggravated with BMD reduction in S-A and BPS OLIF models. More severe motility compensation of the adjacent segment was observed in BPS models than in S-A models. Correspondingly, the surgical segment's stiffness of S-A models was apparently lower than that of BPS models (S-A models showed higher ROMs and lower stiffness in the surgical segment). Conclusion Poor BMD aggravates the motility compensation of adjacent segments after both S-A OLIF and OLIF with BPS fixation. This variation may cause a higher risk of ASD in OLIF patients with poor BMD. S-A OLIF cannot provide instant postoperative stability; therefore, the daily motions of patients with S-A OLIF should be restricted before ideal interbody fusion to avoid surgical segment complications.

Type of Medium: Online Resource

ISSN: 2296-875X

URL: Article

DOI: 10.3389/fsurg.2022.967399

Language: Unknown

Publisher: Frontiers Media SA

Publication Date: 2022

detail.hit.zdb_id: 2773823-1

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Kooperativer Bibliotheksverbund

Berlin Brandenburg