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1

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Alterations of Functional Connectivity Dynamics in Affective and Psychotic Disorders

Hoheisel, Linnea ; Kambeitz-Ilankovic, Lana ; Wenzel, Julian ; [et al.]

Elsevier BV ; 2024

In: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging ( 2024-3)

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In: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, Elsevier BV, ( 2024-3)

Type of Medium: Online Resource

ISSN: 2451-9022

URL: Article

DOI: 10.1016/j.bpsc.2024.02.013

Language: English

Publisher: Elsevier BV

Publication Date: 2024

detail.hit.zdb_id: 2879089-3

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2

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How radical prostatectomy procedures have changed over the last 10 years in Italy: a comparative analysis based on more than 1500 patients participating in the MIRROR-SIU/LUNA and the Pros-IT CNR study

Gacci, Mauro ; Artibani, Walter ; Bassi, Pierfrancesco ; [et al.]

Springer Science and Business Media LLC ; 2021

In: World Journal of Urology Vol. 39, No. 5 ( 2021-05), p. 1445-1452

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In: World Journal of Urology, Springer Science and Business Media LLC, Vol. 39, No. 5 ( 2021-05), p. 1445-1452

Type of Medium: Online Resource

ISSN: 0724-4983 , 1433-8726

URL: Article

DOI: 10.1007/s00345-020-03350-5

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2021

detail.hit.zdb_id: 1463303-6

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3

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Childhood trauma and substance use underlying psychosis: a systematic review

Setién-Suero, Esther ; Suárez-Pinilla, Paula ; Ferro, Adele ; [et al.]

Informa UK Limited ; 2020

In: European Journal of Psychotraumatology Vol. 11, No. 1 ( 2020-12-31)

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In: European Journal of Psychotraumatology, Informa UK Limited, Vol. 11, No. 1 ( 2020-12-31)

Type of Medium: Online Resource

ISSN: 2000-8066

URL: Article

DOI: 10.1080/20008198.2020.1748342

Language: English

Publisher: Informa UK Limited

Publication Date: 2020

detail.hit.zdb_id: 2586642-4

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4

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Significant functional mitral regurgitation affects left atrial function in heart failure patients: haemodynamic correlations and prognostic implications

Palmiero, Giuseppe ; Melillo, Enrico ; Ferro, Adele ; [et al.]

Oxford University Press (OUP) ; 2019

In: European Heart Journal - Cardiovascular Imaging Vol. 20, No. 9 ( 2019-09-01), p. 1012-1019

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In: European Heart Journal - Cardiovascular Imaging, Oxford University Press (OUP), Vol. 20, No. 9 ( 2019-09-01), p. 1012-1019

Abstract: Functional mitral regurgitation (FMR) is a well-known pathophysiological factor in heart failure (HF) patients, and left atrial function (LAF) is a novel determinant of clinical status and outcome in this setting. However, little is known about the pathophysiological role of FMR on LAF in HFrEF patients. Aim of this study is to explore the possible interplay between the severity of FMR and LAF in heart failure with reduce ejection fraction (HFrEF) patients and their possible consequences. Methods and results We studied 97 consecutive patients with FMR classified in two groups: mild-to-moderate MR ore less (FMR group, n = 38) and moderate-to-severe or more (SFMR group, n = 59). Using the phasic method, left atrial contractile, conduit, reservoir, and total emptying function (TLAEF) were calculated to assess LAF. SFMR group showed significantly lower values of LAF compared to FMR group. LA dysfunction (LA-dys) was defined for TLAEF values below the median and groups divided in four subgroups based on its presence. Patient with LA-Dys in SFMR group showed a worse clinical status, higher incidence of right ventricular dysfunction (RV-Dys), and pulmonary hypertension (PH), and a significant worse clinical survival compared to all other groups. Conclusion In our study, the survival was significantly lower in SFMR/LA-Dys+ group. Furthermore, LA-Dys was strongly related with worse clinical status and higher incidence of PH and RV-Dys. These results suggest that in patients with SFMR and HFrEF, LA-Dys may represent both a marker of more advanced disease and a novel prognostic factor.

Type of Medium: Online Resource

ISSN: 2047-2404 , 2047-2412

URL: Article

DOI: 10.1093/ehjci/jez036

Language: English

Publisher: Oxford University Press (OUP)

Publication Date: 2019

detail.hit.zdb_id: 2042482-6

detail.hit.zdb_id: 2647943-6

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5

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Impact of fatigue on health-related quality of life and illness perception in a monocentric cohort of patients with systemic lupus erythematosus

Elefante, Elena ; Tani, Chiara ; Stagnaro, Chiara ; [et al.]

BMJ ; 2020

In: RMD Open Vol. 6, No. 1 ( 2020-02), p. e001133-

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In: RMD Open, BMJ, Vol. 6, No. 1 ( 2020-02), p. e001133-

Abstract: Fatigue is a very common and debilitating symptom in patients with systemic lupus erythematosus (SLE), even among those with a mild or inactive disease. The objective of this study is to define fatigue determinants and describe the impact of fatigue on health-related quality of life (HRQoL) and illness perception in a monocentric cohort of patients with SLE. Methods This is a cross-sectional study. Adult patients with SLE were included. For each patient, demographics, medications, comorbidities, organ damage (Systemic Lupus International Collaborating Clinics Damage Index), active disease manifestations and Systemic Lupus Disease Activity Index scores were collected. It was evaluated if each patient met the definitions of remission and low disease activity. At enrolment, each patient completed the Short Form-36 (SF-36), Functional Assessment Chronic Illness Therapy-Fatigue (FACIT-F), Lupus Impact Tracker (LIT), Systemic Lupus Activity Questionnaire (SLAQ) and Brief Index of Lupus Damage (BILD). The FACIT-F questionnaire was also administered to a group of healthy controls. Results 223 patients were included (mean age 44.9±13.2 years, median disease duration 13 years). 18.2% had an active disease, 43.5% met the definition of remission on treatment, and 11.8% had a concomitant fibromyalgia. The median FACIT-F score of our cohort was significantly lower compared with that of healthy controls (40 vs 47; p 〈 0.001). FACIT-F scores were irrespective of age, disease duration, disease activity and damage. FACIT-F score was significantly lower in patients with fibromyalgia (p 〈 0.01). FACIT-F scores demonstrated a significant correlation with all other patient-reported outcomes: SF-36 (r=0.53–0.77), LIT (r=−0.78), SLAQ (r=−0.72) and BILD (r=−0.28). Conclusions Fatigue in patients with SLE has a strong negative impact on HRQoL and patient perception of the disease burden. Fatigue seems irrespective of disease activity but significantly influenced by the presence of fibromyalgia.

Type of Medium: Online Resource

ISSN: 2056-5933

URL: Article

DOI: 10.1136/rmdopen-2019-001133

Language: English

Publisher: BMJ

Publication Date: 2020

detail.hit.zdb_id: 2812592-7

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6

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PET/CT Imaging in Mouse Models of Myocardial Ischemia

Gargiulo, Sara ; Greco, Adelaide ; Gramanzini, Matteo ; [et al.]

Hindawi Limited ; 2012

In: Journal of Biomedicine and Biotechnology Vol. 2012 ( 2012), p. 1-12

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In: Journal of Biomedicine and Biotechnology, Hindawi Limited, Vol. 2012 ( 2012), p. 1-12

Abstract: Different species have been used to reproduce myocardial infarction models but in the last years mice became the animals of choice for the analysis of several diseases, due to their short life cycle and the possibility of genetic manipulation. Many techniques are currently used for cardiovascular imaging in mice, including X-ray computed tomography (CT), high-resolution ultrasound, magnetic resonance imaging, and nuclear medicine procedures. Cardiac positron emission tomography (PET) allows to examine noninvasively, on a molecular level and with high sensitivity, regional changes in myocardial perfusion, metabolism, apoptosis, inflammation, and gene expression or to measure changes in anatomical and functional parameters in heart diseases. Currently hybrid PET/CT scanners for small laboratory animals are available, where CT adds high-resolution anatomical information. This paper reviews mouse models of myocardial infarction and discusses the applications of dedicated PET/CT systems technology, including animal preparation, anesthesia, radiotracers, and images postprocessing.

Type of Medium: Online Resource

ISSN: 1110-7243 , 1110-7251

URL: Article

DOI: 10.1155/2012/541872

Language: English

Publisher: Hindawi Limited

Publication Date: 2012

detail.hit.zdb_id: 2698540-8

detail.hit.zdb_id: 2512507-2

SSG: 12

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7

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Heterogeneity and Classification of Recent Onset Psychosis and Depression: A Multimodal Machine Learning Approach

Lalousis, Paris Alexandros ; Wood, Stephen J ; Schmaal, Lianne ; [et al.]

Oxford University Press (OUP) ; 2021

In: Schizophrenia Bulletin Vol. 47, No. 4 ( 2021-07-08), p. 1130-1140

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In: Schizophrenia Bulletin, Oxford University Press (OUP), Vol. 47, No. 4 ( 2021-07-08), p. 1130-1140

Abstract: Diagnostic heterogeneity within and across psychotic and affective disorders challenges accurate treatment selection, particularly in the early stages. Delineation of shared and distinct illness features at the phenotypic and brain levels may inform the development of more precise differential diagnostic tools. We aimed to identify prototypes of depression and psychosis to investigate their heterogeneity, with common, comorbid transdiagnostic symptoms. Analyzing clinical/neurocognitive and grey matter volume (GMV) data from the PRONIA database, we generated prototypic models of recent-onset depression (ROD) vs. recent-onset psychosis (ROP) by training support-vector machines to separate patients with ROD from patients with ROP, who were selected for absent comorbid features (pure groups). Then, models were applied to patients with comorbidity, ie, ROP with depressive symptoms (ROP+D) and ROD participants with sub-threshold psychosis-like features (ROD+P), to measure their positions within the affective-psychotic continuum. All models were independently validated in a replication sample. Comorbid patients were positioned between pure groups, with ROP+D patients being more frequently classified as ROD compared to pure ROP patients (clinical/neurocognitive model: χ2 = 14.874; P & lt; .001; GMV model: χ2 = 4.933; P = .026). ROD+P patient classification did not differ from ROD (clinical/neurocognitive model: χ2 = 1.956; P = 0.162; GMV model: χ2 = 0.005; P = .943). Clinical/neurocognitive and neuroanatomical models demonstrated separability of prototypic depression from psychosis. The shift of comorbid patients toward the depression prototype, observed at the clinical and biological levels, suggests that psychosis with affective comorbidity aligns more strongly to depressive rather than psychotic disease processes. Future studies should assess how these quantitative measures of comorbidity predict outcomes and individual responses to stratified therapeutic interventions.

Type of Medium: Online Resource

ISSN: 0586-7614 , 1745-1701

URL: Article

DOI: 10.1093/schbul/sbaa185

RVK:

XA 10000

Language: English

Publisher: Oxford University Press (OUP)

Publication Date: 2021

detail.hit.zdb_id: 2180196-4

SSG: 15,3

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8

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The potential role of the parietal lobe in schizophrenia

Bellani, Marcella ; Ferro, Adele ; Brambilla, Paolo

Cambridge University Press (CUP) ; 2010

In: Epidemiologia e Psichiatria Sociale Vol. 19, No. 2 ( 2010-06), p. 118-119

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In: Epidemiologia e Psichiatria Sociale, Cambridge University Press (CUP), Vol. 19, No. 2 ( 2010-06), p. 118-119

Abstract: Although the anatomy of the parietal lobe has been under-investigated in schizophrenia, some magnetic resonance imaging studies have shown decreased volumes, suggesting its possible implication for the pathophysiology of the disease.

Type of Medium: Online Resource

ISSN: 1121-189X , 2038-1816

URL: Article

DOI: 10.1017/S1121189X00000816

Language: English

Publisher: Cambridge University Press (CUP)

Publication Date: 2010

detail.hit.zdb_id: 2594528-2

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9

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Clinical, Brain, and Multilevel Clustering in Early Psychosis and Affective Stages

Dwyer, Dominic B. ; Buciuman, Madalina-Octavia ; Ruef, Anne ; [et al.]

American Medical Association (AMA) ; 2022

In: JAMA Psychiatry Vol. 79, No. 7 ( 2022-07-01), p. 677-

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In: JAMA Psychiatry, American Medical Association (AMA), Vol. 79, No. 7 ( 2022-07-01), p. 677-

Type of Medium: Online Resource

ISSN: 2168-622X

URL: Article

DOI: 10.1001/jamapsychiatry.2022.1163

Language: English

Publisher: American Medical Association (AMA)

Publication Date: 2022

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Relationships between global functioning and neuropsychological predictors in subjects at high risk of psychosis or with a recent onset of depression

Squarcina, Letizia ; Kambeitz-Ilankovic, Lana ; Bonivento, Carolina ; [et al.]

Informa UK Limited ; 2022

In: The World Journal of Biological Psychiatry Vol. 23, No. 8 ( 2022-09-14), p. 573-581

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In: The World Journal of Biological Psychiatry, Informa UK Limited, Vol. 23, No. 8 ( 2022-09-14), p. 573-581

Type of Medium: Online Resource

ISSN: 1562-2975 , 1814-1412

URL: Article

DOI: 10.1080/15622975.2021.2014955

Language: English

Publisher: Informa UK Limited

Publication Date: 2022

detail.hit.zdb_id: 2170223-8

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Kooperativer Bibliotheksverbund

Berlin Brandenburg