In:
European Journal of Clinical Investigation, Wiley, Vol. 47, No. 2 ( 2017-02), p. 149-157
Abstract:
Soluble ST 2 ( sST 2) has been introduced as a novel biomarker in patients suffering from heart failure for risk stratification. In this study, we sought to investigate whether sST 2 is useful for risk stratification and prediction of mortality in patients undergoing transcatheter aortic valve implantation ( TAVI ). Materials and methods A total of 274 patients undergoing TAVI were included in this study (149 female; age 81 ± 1 years; EUROSCORE 25 ± 1; STS score 3·8 ± 0·2). Plasma samples were obtained preinterventional and analysed for sST 2. Patients were followed up 1 month and 1 year after TAVI . Results In a Cox regression analysis, sST 2 plasma concentration was associated with increased mortality (changes per pg/mL sST 2 concentration; HR 1·00006 95% (1·00004–1·00009); P 〈 0·001). A cut‐off by means of the Youden Index was calculated (10 070·27 pg/mL), and patients were retrospectively divided into two cohorts, in those above (31·3%) and those below (68·7%) this value. These two groups were then compared regarding mortality both after 30 days and 1 year: whereas 1‐month mortality did not differ (7·0% vs. 10·3%, OR 1·50 95% CI (0·60–3·79; P = 0·46)), patients with a sST 2 concentration above the cut‐off of 10 070·27 pg/mL showed a significantly worse outcome after 1 year (49·2% vs. 23·2%; OR 3·21 95% CI (1·70–6·04); P 〈 0·001). After correction for confounders in a multivariate Cox regression analysis, sST 2 (1·0002 95% CI (1·0001–1·0003); P = 0·001) concentration remained associated with mortality. Conclusions sST 2 levels were associated with 1‐year mortality after TAVI . Based on these results, we assume that sST 2 might help to identify patients at high risk for death in whom conservative treatment should be considered.
Type of Medium:
Online Resource
ISSN:
0014-2972
,
1365-2362
DOI:
10.1111/eci.2017.47.issue-2
Language:
English
Publisher:
Wiley
Publication Date:
2017
detail.hit.zdb_id:
2004971-7
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