In:
Clinical Transplantation, Wiley, Vol. 36, No. 12 ( 2022-12)
Abstract:
Alcohol‐associated liver disease (ALD) is a rising indication for liver transplantation (LT). Prolonged opioid use after LT leads to increased graft loss and mortality. The aim is to determine if patients transplanted with a primary diagnosis of ALD had higher risk of post‐LT opioid use (p‐LTOU) compared to non‐ALD patients. Methods This is a retrospective study of patients who underwent LT between 2015 and 2018 at Medstar Georgetown Transplant Institute. Patients with prolonged hospitalization post‐LT ( 〉 90 days), death within 90 days post‐LT, and re‐transplants were excluded. Results Two hundred and ninety seven patients were transplanted, among 29% for indications of ALD. ALD patients were younger (52 vs. 56 years), more likely to be male (76% vs. 61%), Caucasian (71% vs. 44%), have higher MELD (28.8±8.8 vs. 25±8.8), and psychiatric disease than non‐ALD patients ( P 〈 .05). There was no difference in pre‐LT use of opioids, tobacco, marijuana, or illicit drugs between ALD and non‐ALD patients. Pre‐LT opioid use (OR = 11.7, P 〈 .001), ALD (OR = 2.5, P = .01), and MELD score (OR = .95, P = .02) independently predicted 90‐day p‐LTOU. Conclusions ALD, pre‐LT opioid use, and MELD score independently predict p‐LTOU. Special attention should be paid to identify post‐LT prolonged opioid use in ALD patients.
Type of Medium:
Online Resource
ISSN:
0902-0063
,
1399-0012
Language:
English
Publisher:
Wiley
Publication Date:
2022
detail.hit.zdb_id:
2739458-X
detail.hit.zdb_id:
2004801-4
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