In:
Journal of Clinical Periodontology, Wiley, Vol. 31, No. 6 ( 2004-06), p. 449-453
Abstract:
Background: Immunorelevant gene polymorphisms might influence the susceptibility for periodontal disease. The present study assessed the frequency of a promoter polymorphism (−308G‐to‐A) of the tumour necrosis factor (TNF) α gene in patients with periodontitis and controls. Methods: Eighty‐one patients with generalized chronic periodontitis and 80 healthy controls were genotyped for the −308 polymorphism of the TNF α gene by PCR amplification and subsequent restriction fragment length polymorphism analysis. The diagnosis of chronic periodontitis was made for each subject on basis of standardized clinical and radiographic criteria. Results: In patients with peridontitis and controls, the frequency of the TNF α −308 A allele was comparable (19.1% [31/162] versus 13.8% [22/160] ; p =0.193). Conclusion: The present study revealed no association between the −308 TNF α gene polymorphism and periodontal disease.
Type of Medium:
Online Resource
ISSN:
0303-6979
,
1600-051X
DOI:
10.1111/cpe.2004.31.issue-6
DOI:
10.1111/j.1600-051x.2004.00499.x
Language:
English
Publisher:
Wiley
Publication Date:
2004
detail.hit.zdb_id:
2026349-1
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