In:
PLOS ONE, Public Library of Science (PLoS), Vol. 18, No. 7 ( 2023-7-19), p. e0288756-
Abstract:
Hypokalemia is associated with increased risk of arrhythmias and it is recommended to monitor plasma potassium (p-K) regularly in at-risk patients with cardiovascular diseases. It is poorly understood if administration of potassium supplements and mineralocorticoid receptor antagonists (MRA) aimed at increasing p-K also increases intracellular potassium. Methods Adults aged≥18 years with an implantable cardioverter defibrillator (ICD) were randomized (1:1) to a control group or to an intervention that included guidance on potassium rich diets, potassium supplements, and MRA to increase p-K to target levels of 4.5–5.0 mmol/l for six months. Total-body-potassium (TBK) was measured by a Whole-Body-Counter along with p-K at baseline, after six weeks, and after six months. Results Fourteen patients (mean age: 59 years (standard deviation 14), 79% men) were included. Mean p-K was 3.8 mmol/l (0.2), and mean TBK was 1.50 g/kg (0.20) at baseline. After six-weeks, p-K had increased by 0.47 mmol/l (95%CI:0.14;0.81), p = 0.008 in the intervention group compared to controls, whereas no significant difference was found in TBK (44 mg/kg (-20;108), p = 0.17). After six-months, no significant difference was found in p-K as compared to baseline (0.16 mmol/l (-0.18;0.51), p = 0.36), but a significant increase in TBK of 82 mg/kg (16;148), p = 0.017 was found in the intervention group compared to controls. Conclusions Increased potassium intake and MRAs increased TBK gradually and a significant increase was seen after six months. The differentially regulated p-K and TBK challenges current knowledge on potassium homeostasis and the time required before the full potential of p-K increasing treatment can be anticipated. Trial registration www.clinicaltrials.gov ( NCT03833089 ).
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0288756
DOI:
10.1371/journal.pone.0288756.g001
DOI:
10.1371/journal.pone.0288756.g002
DOI:
10.1371/journal.pone.0288756.t001
DOI:
10.1371/journal.pone.0288756.s001
DOI:
10.1371/journal.pone.0288756.s002
DOI:
10.1371/journal.pone.0288756.s003
DOI:
10.1371/journal.pone.0288756.s004
DOI:
10.1371/journal.pone.0288756.s005
DOI:
10.1371/journal.pone.0288756.s006
DOI:
10.1371/journal.pone.0288756.r001
DOI:
10.1371/journal.pone.0288756.r002
DOI:
10.1371/journal.pone.0288756.r003
DOI:
10.1371/journal.pone.0288756.r004
DOI:
10.1371/journal.pone.0288756.r005
DOI:
10.1371/journal.pone.0288756.r006
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2023
detail.hit.zdb_id:
2267670-3
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