In:
Journal of Clinical Oncology, American Society of Clinical Oncology (ASCO), Vol. 37, No. 15_suppl ( 2019-05-20), p. e23021-e23021
Abstract:
e23021 Background: The independent prognostic value of both oncological and geriatric parameters is well-established in older cancer patients. Yet little is known about the causal pathways between them and how they may interact to affect mortality. Using structural equation modeling (SEM), we aimed to assess the direct and indirect impact of geriatric impairments and oncological parameters on mortality in older patients with cancer. Methods: Patients ≥70 years recruited in the ELCAPA cohort for geriatric assessment (GA), between 2007 and 2016, were included. The six following geriatric domains were assessed: function and mobility, nutrition, cognition, mood, comorbidities and polypharmacy, and social support. SEM analysis tested prespecified relationships between geriatric and oncological characteristics (i.e. stage, cancer site and anti-cancer treatment) and their influence on 6- and 12-months mortality following GA. Model fit was assessed through Root Mean Squared Error of Approximation (RMSEA) and Tucker-Lewis Index (TLI). Results: This analysis included 1434 patients (mean age, 80 years (±5.6); female, 48%; 48% metastasis; main localizations: colorectal (19%), upper digestive tract (17%), and breast (17%)). The 6- and 12-months mortality were 56% and 68%, respectively. Significant direct paths to increased mortality were identified for functional impairment (standardized coefficient (SC): 0.37; p 〈 0.001 and 0.32; p 〈 0.001), poor nutritional status (SC: 0.11; p = 0.005 and 0.14; p = 0.001) and poor social support (SC = 0.07; p = 0.08 and 0.09; p = 0.02), along with tumor site, metastatic status and anti-cancer treatment. SEM additionally revealed the indirect effects on mortality of comorbidities, cognitive impairment and depression mediated through functional and nutritional status. Model fit was excellent (RMSEA = 0.036, TLI = 0.941). Conclusions: SEM analysis showed the direct effects of functional and nutritional impairments on mortality and also revealed their central mediating role in the indirect impact of comorbidities, depression and cognitive impairment on mortality. Clinical trial information: NCT02884375.
Type of Medium:
Online Resource
ISSN:
0732-183X
,
1527-7755
DOI:
10.1200/JCO.2019.37.15_suppl.e23021
Language:
English
Publisher:
American Society of Clinical Oncology (ASCO)
Publication Date:
2019
detail.hit.zdb_id:
2005181-5
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